Product image of Lidokain/Adrenalin Aguettant (Epinephrine, Lidocaine Hydrochloride) supplied by GNH India

Lidokain/Adrenalin Aguettant

Active Ingredient:
Epinephrine, Lidocaine Hydrochloride
Origin:
EU

Lidokain/Adrenalin Aguettant (Epinephrine, Lidocaine Hydrochloride)

Lidocaine Hydrochloride and Epinephrine, the active ingredient in Lidokain/Adrenalin Aguettant, is a local anesthetic and vasoconstrictor presented as a sterile solution for injection for epidural, infiltration, intravenous and perineural use. It provides rapid onset anesthesia and prolongs effect by reducing local blood flow, making it suitable for minor surgical procedures and regional blocks.

GNH India supplies Lidokain/Adrenalin Aguettant as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Laboratoire Aguettant

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Indications & Clinical Uses

Lidokain/Adrenalin Aguettant, a combination local anesthetic and vasoconstrictor, is employed in procedures that require regional or infiltration anesthesia.

  • Minor surgical procedures: provides local anesthesia and reduces intra‑operative bleeding.
  • Infiltration anesthesia: enables targeted numbness of tissue during minor interventions.
  • Epidural anesthesia: extends duration of analgesia for labor or surgical procedures.
  • Perineural (regional) anesthesia: facilitates nerve block for limb surgeries.

How It Works

  • Lidocaine blocks voltage‑gated sodium channels on neuronal membranes, preventing propagation of nerve impulses and producing loss of sensation. Epinephrine activates alpha‑ and beta‑adrenergic receptors, causing vasoconstriction that limits systemic absorption of lidocaine, thereby prolonging its anesthetic effect and reducing bleeding at the injection site.

Side Effects

Adverse reactions may occur following administration of the combination solution.

Common Side Effects

  • Transient pain or burning at the injection site
  • Tachycardia
  • Hypertension
  • Nausea
  • Light‑headedness
  • Localized swelling

Serious or Rare Side Effects

  • Anaphylactic reaction
  • Severe cardiac arrhythmia
  • Seizure activity
  • Methemoglobinemia
  • Persistent hypotension
  • Respiratory depression

Precautions & Warnings

Careful assessment and monitoring are required when using this anesthetic combination.

  • Allergy assessment: verify no known hypersensitivity to lidocaine or epinephrine.
  • Cardiovascular status: avoid in patients with uncontrolled hypertension, arrhythmias, or severe coronary disease.
  • Dosage limits: adhere to recommended maximum lidocaine dose to prevent systemic toxicity.
  • Pregnancy: use only if potential benefit justifies potential risk to the fetus.
  • Drug interactions: review concomitant medications for possible additive cardiovascular effects.
  • Store at ambient temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Lidokain/Adrenalin Aguettant may interact with several drug classes; monitoring is essential.

Major Interactions (Avoid)

  • Beta‑blockers: may potentiate hypertension and tachycardia.
  • Monoamine oxidase inhibitors (MAOIs): increase risk of hypertensive crisis.
  • Tricyclic antidepressants: may enhance cardiotoxicity of lidocaine.

Moderate Interactions (Monitor Closely)

  • Other local anesthetics: risk of cumulative systemic toxicity.
  • Diuretics: may alter plasma lidocaine concentrations.
  • Calcium channel blockers: may modify cardiovascular response to epinephrine.

Frequently Asked Questions

Lidokain/Adrenalin Aguettant is a combination of lidocaine and epinephrine used to provide local or regional anesthesia for minor surgical procedures, infiltration, epidural, and perineural blocks. The epinephrine component prolongs the anesthetic effect and reduces bleeding at the injection site.

Lidocaine blocks voltage‑gated sodium channels, stopping nerve impulse transmission and producing numbness. Epinephrine stimulates alpha‑adrenergic receptors, causing vasoconstriction that limits systemic absorption of lidocaine, thereby extending its duration of action and minimizing intra‑operative bleeding.

The specific dose and concentration are determined by the prescribing clinician based on the procedure, patient weight, and clinical guidelines. Healthcare professionals calculate the appropriate volume to stay within recommended maximum lidocaine limits and consider epinephrine concentration for safety.

Safety data for Lidokain/Adrenalin Aguettant in pregnancy and lactation are limited. It should be used only if the potential therapeutic benefit justifies any potential risk to the fetus or infant, and the decision must be made by the treating physician.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Compared with plain lidocaine solutions, the addition of epinephrine prolongs anesthesia, reduces systemic absorption, and decreases bleeding. Unlike some newer agents, this combination is well‑established, cost‑effective, and widely used for a variety of regional techniques, though it shares similar toxicity thresholds.

Lidokain/Adrenalin Aguettant should be stored at ambient temperature, below 25 °C, in its original sealed container. Protect the solution from direct sunlight, moisture, and extreme temperatures. Do not freeze; inspect for particulate matter before use.

The sterile solution is administered by a qualified healthcare professional via injection. Routes include epidural, infiltration, intravenous, or perineural administration, depending on the clinical indication and procedural requirements. Proper aseptic technique and dosage calculation are essential.

Serious adverse events include anaphylaxis, severe cardiac arrhythmias, seizures, and methemoglobinemia. Immediate medical attention is required if patients develop signs of allergic reaction, profound cardiovascular instability, or neurologic symptoms after administration.

Patients with known hypersensitivity to lidocaine, epinephrine, or any component of the formulation should avoid this product. It is also contraindicated in individuals with uncontrolled hypertension, certain cardiac conduction disorders, or those taking non‑selective MAO inhibitors.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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