Product image of Lidokain/Adrenalin Aguettant (Epinephrine, Lidocaine Hydrochloride) supplied by GNH India

Lidokain/Adrenalin Aguettant

Active Ingredient:
Epinephrine, Lidocaine Hydrochloride
Origin:
EU

Lidokain/Adrenalin Aguettant (Epinephrine, Lidocaine Hydrochloride)

Lidocaine hydrochloride, the active ingredient in Lidokain/Adrenalin Aguettant, is a local anesthetic presented as a sterile solution for epidural, infiltration, and perineural use. It provides rapid onset nerve block and is combined with epinephrine to extend duration in surgical and diagnostic procedures.

GNH India supplies Lidokain/Adrenalin Aguettant as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Laboratoire Aguettant

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Indications & Clinical Uses

Lidokain/Adrenalin is a local anesthetic combination used in procedures requiring regional nerve blockade.

  • Surgical anesthesia: provides localized numbness for minor to moderate surgical procedures.
  • Epidural analgesia: delivers pain relief during labor or postoperative periods.
  • Peripheral nerve block: facilitates anesthesia for limb surgeries.

How It Works

  • Lidocaine blocks voltage‑gated sodium channels in neuronal membranes, preventing depolarization and impulse conduction. Epinephrine activates α‑adrenergic receptors causing vasoconstriction, which reduces systemic absorption of lidocaine, prolongs its local effect, and limits bleeding at the injection site.

Side Effects

Common Side Effects

  • Tingling or burning at the injection site.
  • Transient increase in heart rate.
  • Mild hypotension.
  • Nausea or vomiting.
  • Light‑headedness.
  • Local swelling or erythema.

Serious or Rare Side Effects

  • Anaphylactic reaction or severe allergic response.
  • Cardiac arrhythmias, including ventricular tachycardia.
  • Seizures or central nervous system toxicity.
  • Methemoglobinemia.
  • Persistent numbness beyond expected duration.
  • Severe hypertension.

Precautions & Warnings

Lidokain/Adrenalin should be used with careful clinical assessment.

  • Assess patient allergy: verify no known hypersensitivity to lidocaine or epinephrine.
  • Monitor cardiovascular status: observe heart rate and blood pressure during administration.
  • Limit total dose: adhere to recommended maximum lidocaine dose for the procedure.
  • Avoid use in infected tissue: do not inject into areas with active infection.
  • Use caution in patients with thyroid disease: epinephrine may exacerbate symptoms.
  • Store at room temperature: keep in the original container, protect from light and moisture.

Avoid Interactions

Lidokain/Adrenalin may interact with several drug classes.

Major Interactions (Avoid)

  • Beta‑blockers: may potentiate epinephrine‑induced hypertension.
  • Monoamine oxidase inhibitors: increase risk of hypertensive crisis.
  • Tricyclic antidepressants: may enhance cardiotoxicity of lidocaine.

Moderate Interactions (Monitor Closely)

  • Class I antiarrhythmics: may increase lidocaine plasma levels.
  • Diuretics: may alter lidocaine clearance.
  • Theophylline: may increase risk of central nervous system toxicity.

Frequently Asked Questions

Lidokain/Adrenalin Aguettant is a sterile solution that combines lidocaine hydrochloride with epinephrine. It is used to provide local anesthesia for surgical or diagnostic procedures, epidural analgesia, and peripheral nerve blocks, helping to numb targeted areas while reducing bleeding and prolonging the anesthetic effect.

Lidocaine blocks voltage‑gated sodium channels on neuronal membranes, which prevents the initiation and propagation of nerve impulses. By inhibiting these signals, it produces a reversible loss of sensation in the area where it is administered.

The specific dose of Lidokain/Adrenalin is determined by the prescribing clinician based on the type of procedure, patient weight, and clinical setting. Healthcare professionals calculate the appropriate volume and concentration to stay within recommended safety limits.

Safety data for Lidokain/Adrenalin during pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.

To order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and import documentation.

Plain lidocaine provides rapid local anesthesia but has a shorter duration and may cause more bleeding at the injection site. Adding epinephrine, as in Lidokain/Adrenalin, causes vasoconstriction, which prolongs anesthesia, reduces systemic absorption, and minimizes intra‑procedural bleeding, making it preferable for many surgical applications.

Lidokain/Adrenalin should be stored at room temperature, below 25 °C, in its original sealed container. Protect the solution from direct light and moisture. Do not freeze. Inspect the vial for particulate matter before use and discard if the solution appears discolored or contaminated.

The product is administered by a qualified healthcare professional via injection. It can be given epidurally, infiltratively, or perineurally, depending on the intended procedure. Proper aseptic technique and dosage calculation are essential to ensure safety and effectiveness.

Serious risks include severe allergic reactions (anaphylaxis), cardiac arrhythmias, seizures, methemoglobinemia, and profound hypertension. Immediate medical attention is required if any of these events occur during or after administration.

Patients with known hypersensitivity to lidocaine, epinephrine, or any component of the formulation should avoid this product. It is also contraindicated in areas of infection, in patients with uncontrolled hyperthyroidism, or in those receiving non‑selective beta‑blockers where epinephrine effects may be unpredictable.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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