Product image of Lidokain-Adrenalin Sad (Epinephrine, Lidocaine Hydrochloride) supplied by GNH India

Lidokain-Adrenalin Sad

Active Ingredient:
Epinephrine, Lidocaine Hydrochloride
Origin:
EU

Lidokain-Adrenalin Sad (Epinephrine, Lidocaine Hydrochloride)

Lidocaine Hydrochloride, the active ingredient in Lidokain-Adrenalin Sad, is a local anesthetic presented as a solution for intramuscular and subcutaneous use. It provides rapid numbness of tissue for minor surgical or dental procedures in adult patients and helps facilitate painless wound closure.

GNH India supplies Lidokain-Adrenalin Sad as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation to support import and distribution across EU and other markets.

Manufacturer / TM Owner

Amgros I/S

1
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Indications & Clinical Uses

  • Lidokain-Adrenalin Sad, a combination of lidocaine and epinephrine, is employed in local anesthesia for procedures involving soft tissue.
  • Dental procedures: provides rapid onset numbness and reduces bleeding during extractions or restorative work.
  • Minor skin surgery: enables painless excision of lesions and controls intra‑operative bleeding.
  • Suturing of small lacerations: facilitates comfortable wound closure with prolonged anesthetic effect.

How It Works

  • Lidocaine blocks voltage‑gated sodium channels on neuronal membranes, preventing depolarization and halting nerve impulse transmission. Epinephrine stimulates α‑adrenergic receptors on vascular smooth muscle, causing vasoconstriction. The resulting reduced blood flow limits systemic absorption of lidocaine, prolonging its anesthetic duration and minimizing bleeding at the procedural site. This synergistic action allows clinicians to use lower concentrations of lidocaine while achieving effective analgesia for up to several hours.

Side Effects

Adverse reactions to Lidokain-Adrenalin Sad may vary in frequency and severity.

Common Side Effects

  • Transient burning or stinging at the injection site
  • Mild dizziness or light‑headedness
  • Nausea
  • Tachycardia due to epinephrine

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis)
  • Cardiac arrhythmias or myocardial ischemia
  • Persistent numbness or neurological deficits

Precautions & Warnings

  • When using Lidokain-Adrenalin Sad, consider the following precautions.
  • Allergy assessment: verify no known hypersensitivity to lidocaine, epinephrine or amide‑type anesthetics.
  • Cardiovascular status: use cautiously in patients with uncontrolled hypertension, arrhythmias, or ischemic heart disease.
  • Dosage limits: avoid exceeding recommended maximum lidocaine dose to prevent systemic toxicity.
  • Pregnancy and lactation: consider risk‑benefit; limited data, use only if clearly needed.
  • Drug interactions: review concomitant medications that may potentiate epinephrine effects.
  • Store at room temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Lidokain-Adrenalin Sad may interact with other medicines; awareness of the interaction level is important.

Major Interactions (Avoid)

  • Class I antiarrhythmic agents (e.g., quinidine, procainamide): may increase lidocaine plasma levels and toxicity.
  • Beta‑blockers (e.g., propranolol): can potentiate epinephrine‑induced hypertension and tachycardia.
  • Monoamine oxidase inhibitors: may enhance epinephrine effects.

Moderate Interactions (Monitor Closely)

  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): may increase bleeding risk when combined with epinephrine vasoconstriction.
  • Diuretics (e.g., furosemide): may reduce plasma volume, altering lidocaine distribution.
  • Tricyclic antidepressants: may lower seizure threshold when combined with lidocaine.

Frequently Asked Questions

Lidokain-Adrenalin Sad is a sterile solution that combines lidocaine and epinephrine to provide local anesthesia. It is commonly used to numb tissue and reduce bleeding during minor surgical, dental, and dermatologic procedures, allowing clinicians to perform interventions with improved patient comfort.

Lidocaine blocks voltage‑gated sodium channels on nerves, stopping the transmission of pain signals. Epinephrine activates alpha‑adrenergic receptors, causing blood vessels to constrict. This vasoconstriction limits lidocaine absorption, prolongs its anesthetic effect, and reduces bleeding at the treatment site.

The appropriate dose is determined by the prescribing healthcare professional based on the type of procedure, the size of the treatment area, patient weight, and overall health status. Clinicians calculate the amount to stay within safe lidocaine limits and achieve the desired anesthetic duration.

Safety data for this combination in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant. The prescriber should evaluate the clinical situation and discuss alternatives if concerns exist.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Compared with plain lidocaine, the addition of epinephrine in Lidokain-Adrenalin Sad provides vasoconstriction, which prolongs the anesthetic effect, reduces systemic absorption, and minimizes intra‑operative bleeding. This can allow lower total lidocaine doses while achieving comparable or longer duration of numbness.

Lidokain-Adrenalin Sad should be stored at room temperature, below 25 °C, in its original container. Protect the solution from direct sunlight, moisture, and extreme temperature fluctuations. Do not freeze the product, and keep it out of reach of children.

The solution is administered by a qualified healthcare professional via intramuscular or subcutaneous injection directly into the tissue surrounding the procedural site. The injection technique follows standard aseptic practices, and the volume injected is based on the size of the area to be anesthetized.

Serious risks include severe allergic reactions (anaphylaxis), cardiac arrhythmias or myocardial ischemia due to epinephrine, and systemic lidocaine toxicity, which can manifest as seizures, respiratory depression, or cardiovascular collapse. Immediate medical attention is required if any of these events occur.

Patients with known hypersensitivity to lidocaine, epinephrine, or any amide‑type local anesthetics should avoid this product. It is also contraindicated in individuals with uncontrolled hypertension, severe cardiac disease, or certain arrhythmias where epinephrine‑induced vasoconstriction could be harmful.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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