Product image of Lidokainklorid/Adrenalin Belupo (Epinephrine, Lidocaine Hydrochloride) supplied by GNH India

Lidokainklorid/Adrenalin Belupo

Active Ingredient:
Epinephrine, Lidocaine Hydrochloride
Origin:
EU

Lidokainklorid/Adrenalin Belupo (Epinephrine, Lidocaine Hydrochloride)

Lidocaine Hydrochloride and Epinephrine, the active ingredients in Lidokainklorid/Adrenalin Belupo, are a local anesthetic with vasoconstrictor presented as a solution for injection for epidural and infiltration use. They provide rapid onset of numbness and prolong the anesthetic effect in surgical and diagnostic procedures.

GNH India supplies Lidokainklorid/Adrenalin Belupo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, clinics and surgical centres worldwide, ensuring consistent quality and regulatory compliance across markets. The company provides reliable logistics and documentation to meet global procurement standards.

Manufacturer / TM Owner

Belupo D.D.

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Indications & Clinical Uses

Lidokainklorid/Adrenalin Belupo is used for local anesthesia in procedures involving the epidural space or tissue infiltration.

  • Epidural anesthesia: provides numbness for labor, surgical or diagnostic procedures involving the spinal column
  • Infiltration anesthesia: numbs targeted tissue for minor surgeries, dental work, or wound repair
  • Peripheral nerve block: extends duration of anesthesia for limb surgeries or pain management

How It Works

  • Lidocaine blocks voltage‑gated sodium channels on neuronal membranes, preventing depolarization and nerve impulse transmission. Epinephrine activates alpha‑adrenergic receptors on vascular smooth muscle, causing vasoconstriction that reduces local blood flow, limits systemic absorption of lidocaine, and prolongs its anesthetic effect.

Side Effects

Adverse reactions may occur following administration of the lidocaine‑epinephrine solution.

Common Side Effects

  • Transient burning or stinging at the injection site
  • Mild swelling or erythema around the injection area
  • Temporary increase in heart rate (tachycardia)
  • Elevated blood pressure (hypertension)

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis)
  • Cardiac arrhythmias, including ventricular tachycardia
  • Seizures due to systemic lidocaine toxicity
  • Methemoglobinemia, a rare blood disorder

Precautions & Warnings

Before use, clinicians should consider several safety measures.

  • Allergy assessment: verify no known hypersensitivity to lidocaine or epinephrine
  • Cardiovascular status: use cautiously in patients with uncontrolled hypertension
  • Pregnancy: evaluate risk‑benefit before administration
  • Age considerations: adjust use in pediatric or geriatric patients as per clinical judgment
  • Drug interactions: review concomitant medications for potential interactions
  • Store below 25°C: keep in the original container, protect from moisture and light

Avoid Interactions

Lidokainklorid/Adrenalin Belupo may interact with other medicines.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors (MAOIs): risk of hypertensive crisis
  • Beta‑blockers: may potentiate cardiac effects of epinephrine
  • Class I antiarrhythmics: increased risk of arrhythmias

Moderate Interactions (Monitor Closely)

  • Tricyclic antidepressants: may enhance lidocaine toxicity
  • Diuretics: may alter plasma epinephrine levels
  • Non‑selective beta agonists: may reduce the vasoconstrictive effect of epinephrine

Frequently Asked Questions

Lidokainklorid/Adrenalin Belupo is a sterile solution that provides local anesthesia for epidural and infiltration procedures, helping to numb tissue during surgery, diagnostic interventions, or pain‑management techniques.

Lidocaine blocks voltage‑gated sodium channels on nerve cells, preventing the initiation and propagation of electrical impulses, which results in loss of sensation in the targeted area.

The specific dose and volume are determined by the prescribing clinician based on the procedure, patient characteristics, and clinical guidelines. No standard dosing is provided here.

Safety in pregnancy and lactation has not been definitively established. Clinicians should weigh potential benefits against risks and consider alternative options when appropriate.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and necessary import documentation.

Lidokainklorid/Adrenalin combines lidocaine with epinephrine, offering rapid onset and prolonged duration compared with lidocaine alone. The vasoconstrictor reduces bleeding and systemic absorption, which can be advantageous over plain anesthetic solutions.

Store the solution below 25 °C in its original container, protecting it from moisture and direct light. Do not freeze. Inspect the vial for particulate matter before use.

The product is administered by a qualified healthcare professional via injection into the epidural space or directly into tissue for infiltration, following aseptic technique and standard procedural protocols.

Serious risks include severe allergic reactions (anaphylaxis), cardiac arrhythmias, seizures from systemic lidocaine toxicity, and rare cases of methemoglobinemia. Immediate medical attention is required if these occur.

Patients with known hypersensitivity to lidocaine, epinephrine, or any component of the formulation should avoid this product. Caution is also advised for individuals with uncontrolled hypertension, significant cardiac disease, or certain drug interactions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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