Lidonostrum (Lidocaine)

Lidonostrum is a local anesthetic that acts on peripheral nerve sodium channels to provide surface analgesia.

• Local anesthesia of skin: produces temporary numbness for minor surgical or diagnostic procedures.
• Pain relief: reduces superficial pain associated with minor injuries or procedures.
• Pruritus: alleviates itching by blocking sensory nerve transmission.

• Lidocaine blocks voltage‑gated sodium channels in neuronal membranes, stabilizing the neuronal membrane and preventing the initiation and propagation of action potentials. This inhibition of nerve impulse conduction results in loss of sensation in the area where the drug is applied.

Adverse reactions may occur following cutaneous application of lidocaine.

Common Side Effects

• Mild skin irritation or burning sensation at the application site.
• Redness or erythema.
• Localized itching.
• Swelling or edema.
• Transient numbness extending beyond the intended area.
• Dryness or peeling of the skin.

Serious or Rare Side Effects

• Allergic reactions such as urticaria, angioedema, or anaphylaxis.
• Systemic toxicity manifesting as dizziness, tinnitus, or seizures.
• Cardiac arrhythmias or conduction disturbances.
• Methemoglobinemia.
• Severe skin necrosis or ulceration.
• Persistent numbness or motor weakness.

When using Lidonostrum, consider the following safety measures.

• Allergy assessment: verify that the patient has no known hypersensitivity to lidocaine or amide‑type anesthetics.
• Application area: avoid applying to broken skin, mucous membranes, or extensive open wounds.
• Dose limitation: adhere strictly to the prescribed amount to prevent systemic absorption.
• Concurrent anesthetics: do not combine with other topical anesthetics without medical guidance.
• Pregnancy and lactation: consult a prescriber as safety data are limited.
• Store below 25°C: keep in the original container, protect from moisture and light.

Lidonostrum may interact with other medicines that affect cardiac or nervous system function.

Major Interactions (Avoid)

• Other amide‑type local anesthetics: concurrent use can increase systemic toxicity.
• Class I antiarrhythmics (e.g., quinidine, procainamide): may enhance cardiotoxic effects.
• Strong CYP3A4 inhibitors (e.g., ketoconazole): may reduce lidocaine metabolism.

Moderate Interactions (Monitor Closely)

• Beta‑blockers: may mask early signs of lidocaine toxicity.
• Diuretics: can alter plasma concentrations of lidocaine.
• General anesthetics: may potentiate central nervous system depression.