Product image of Lidonostrum (Lidocaine) supplied by GNH India

Lidonostrum

Active Ingredient:
Lidocaine
Origin:
EU

Lidonostrum (Lidocaine)

Lidocaine, the active ingredient in Lidonostrum, is a local anesthetic presented as a topical formulation for cutaneous, nasal, oral, or oromucosal use. It provides temporary numbing of surface tissues in adults and children as directed by a healthcare professional.

GNH India supplies Lidonostrum as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Sidefarma - Sociedade Industrial De Expansão Farmacêutica, S.A.

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Indications & Clinical Uses

Lidocaine is used to achieve local anesthesia in various superficial tissues and mucous membranes.

  • Minor skin procedures: provides rapid surface numbness for suturing, biopsies, or laser treatment.
  • Oral or oropharyngeal discomfort: relieves pain from aphthous ulcers, sore throat, or dental procedures.
  • Nasal procedures: numbs nasal mucosa for endoscopic examinations or minor surgeries.

How It Works

  • Lidocaine blocks voltage‑gated sodium channels on neuronal membranes, preventing the influx of sodium ions required for depolarization. This inhibition stops the generation and propagation of nerve impulses, resulting in reversible loss of sensation in the area where the drug is applied.

Side Effects

Lidocaine can cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Burning or stinging at the application site.
  • Redness or mild swelling of the skin or mucosa.
  • Nausea or mild dizziness.
  • Headache.
  • Temporary taste alteration when used orally.

Serious or Rare Side Effects

  • Systemic toxicity presenting as seizures, cardiac arrhythmias, or profound hypotension.
  • Allergic reactions such as rash, itching, or angioedema.
  • Methemoglobinemia, especially with extensive mucosal use.
  • Persistent numbness beyond the expected duration.
  • Severe local tissue irritation or ulceration.

Precautions & Warnings

When using lidocaine, consider the following safety measures.

  • Dosage limits: adhere to recommended maximum amounts to avoid systemic toxicity.
  • Application area: avoid use on large surface areas or broken skin unless directed.
  • Concomitant anesthetics: do not combine with other topical anesthetics without professional guidance.
  • Medical history: assess for cardiac, hepatic, or renal impairment before use.
  • Pediatric use: adjust amount according to weight and age under medical supervision.
  • Store at ambient temperature: keep in the original container, protect from moisture and heat.

Avoid Interactions

Lidocaine may interact with other substances that affect cardiac conduction or metabolism.

Major Interactions (Avoid)

  • Class I antiarrhythmics (e.g., quinidine, procainamide): additive cardiac conduction effects.
  • CYP3A4 inhibitors (e.g., ketoconazole, erythromycin): may increase lidocaine plasma levels.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: potential for enhanced bradycardia.
  • Other local anesthetics: risk of cumulative toxicity.
  • Monoamine oxidase inhibitors: may alter hemodynamic response.

Frequently Asked Questions

Lidonostrum contains lidocaine, a local anesthetic that provides temporary numbness of skin, oral, nasal or oromucosal tissues. It is commonly employed to reduce pain during minor surgical or diagnostic procedures, to soothe oral discomfort, and to anesthetize nasal passages for endoscopic examinations.

Lidocaine blocks voltage‑gated sodium channels on nerve cells, preventing the rapid influx of sodium that initiates an action potential. By inhibiting nerve impulse conduction, the drug produces reversible loss of sensation in the area where it is applied.

The appropriate dose of Lidonostrum is determined by the prescribing healthcare professional based on the intended use, the size of the treatment area, patient age, and medical condition. Patients should follow the exact instructions provided by their clinician.

Safety data for lidocaine in pregnancy and lactation are limited. Use of Lidonostrum during pregnancy or while breastfeeding should only occur if the potential benefit justifies any potential risk to the fetus or infant, and under direct medical supervision.

To order Lidonostrum, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lidonostrum’s lidocaine is comparable to other amide‑type local anesthetics such as prilocaine or mepivacaine in onset and duration of action. Choice among them depends on factors like required depth of anesthesia, potential for allergic reactions, and specific procedural needs.

Lidonostrum should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture, direct sunlight and excessive heat to maintain stability.

Lidonostrum is applied topically to the intended surface—skin, oral mucosa, nasal mucosa, or other accessible tissues. The clinician spreads a thin layer of the preparation, allowing it to absorb for the recommended contact time before proceeding with the procedure.

The most serious risks include systemic lidocaine toxicity, which can manifest as seizures, cardiac arrhythmias, or severe hypotension, and rare allergic reactions such as anaphylaxis. Prompt medical attention is required if any signs of systemic toxicity or severe hypersensitivity appear.

Lidonostrum should be avoided in individuals with known hypersensitivity to lidocaine or other amide‑type anesthetics, in patients with severe cardiac conduction disorders, and in those who have taken excessive amounts of other local anesthetics without medical guidance.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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