Product image of Lidonostrum (Lidocaine) supplied by GNH India

Lidonostrum

Active Ingredient:
Lidocaine
Origin:
EU

Lidonostrum (Lidocaine)

Lidocaine, the active ingredient in Lidonostrum, is a local anesthetic presented as a topical formulation for cutaneous, nasal, oral and oromucosal use. It provides temporary loss of sensation to facilitate minor procedures or relieve localized pain on the skin and mucous membranes.
GNH India supplies Lidonostrum as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Sidefarma - Sociedade Industrial De Expansão Farmacêutica, S.A.

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Indications & Clinical Uses

Lidonostrum is a local anesthetic that acts on peripheral nerve membranes to produce reversible loss of sensation.

  • Skin (cutaneous) anesthesia: provides temporary numbness for minor dermatologic procedures or pain relief on the skin.
  • Nasal mucosa anesthesia: numbs the nasal lining to facilitate endoscopic examinations or minor surgeries.
  • Oral and oromucosal anesthesia: creates localized numbness for dental work, oral surgeries, or relief of oral mucosal discomfort.

How It Works

  • Lidocaine blocks voltage‑gated sodium channels in neuronal membranes, stabilising the neuronal membrane and preventing the initiation and propagation of action potentials. This inhibition of sodium influx halts nerve impulse transmission, resulting in reversible loss of sensation in the area where the drug is applied.

Side Effects

Lidocaine is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Burning or stinging at the application site
  • Itching or mild skin irritation
  • Redness or erythema
  • Swelling or edema of the treated area
  • Dry mouth or altered taste when used intra‑oral
  • Mild headache

Serious or Rare Side Effects

  • Systemic toxicity (e.g., dizziness, seizures, cardiac arrhythmia)
  • Allergic reactions such as rash, urticaria, or angioedema
  • Methemoglobinemia, especially with extensive mucosal use
  • Severe skin reactions (e.g., Stevens‑Johnson syndrome)
  • Persistent numbness beyond the expected duration
  • Respiratory depression in cases of overdose

Precautions & Warnings

When using Lidonostrum, consider the following safety measures.

  • Allergy assessment: confirm no known hypersensitivity to lidocaine or other amide‑type anesthetics.
  • Application area: limit use to the intended surface and avoid excessive quantities.
  • Patient monitoring: observe for signs of systemic absorption, especially in children or patients with compromised skin integrity.
  • Drug interactions: review concomitant medications that may increase lidocaine plasma levels.
  • Storage: Store below 25°C: keep in the original packaging, protect from moisture and direct light.

Avoid Interactions

Lidocaine may interact with other agents that affect cardiac conduction or sodium channel activity.

Major Interactions (Avoid)

  • Other local anesthetics: cumulative toxicity risk.
  • Class I antiarrhythmic drugs (e.g., quinidine, procainamide): may potentiate cardiac effects.
  • CYP3A4 inhibitors (e.g., ketoconazole, erythromycin): can increase lidocaine plasma concentrations.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers (e.g., propranolol): may enhance bradycardia.
  • Diuretics (e.g., furosemide): may alter electrolyte balance, affecting lidocaine activity.
  • Anticonvulsants (e.g., phenytoin): may modify seizure threshold when lidocaine systemic levels rise.

Frequently Asked Questions

Lidonostrum contains lidocaine, a local anesthetic used to provide temporary numbness of the skin, nasal passages, and oral or oromucosal surfaces. It is applied to facilitate minor surgical or diagnostic procedures and to relieve localized pain in these areas.

Lidocaine blocks voltage‑gated sodium channels on peripheral nerves, preventing the influx of sodium ions that is necessary for the generation and propagation of action potentials. This interruption stops nerve signal transmission, resulting in reversible loss of sensation at the site of application.

The appropriate dose of Lidonostrum is determined by the prescribing healthcare professional based on the specific indication, the size of the treatment area, patient age, and other clinical factors. No fixed regimen is provided; the prescriber sets the amount and frequency of application.

Safety data for lidocaine in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant. Healthcare providers should evaluate each case individually and discuss any concerns with the patient.

To order Lidonostrum, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials before providing pricing, availability, shipping details and any necessary import documentation.

Lidonostrum (lidocaine) offers rapid onset and moderate duration of action, making it suitable for many superficial procedures. Compared with benzocaine, lidocaine provides deeper penetration and less allergic potential, while agents like prilocaine may have a slower onset. Choice depends on the procedure, required depth of anesthesia and patient tolerance.

Lidonostrum should be stored below 25 °C in its original container, protected from moisture and direct sunlight. Keep the product out of reach of children and avoid freezing. Ensure the packaging remains sealed until use to maintain product integrity.

Lidonostrum is applied topically to the target area. For skin use, a thin layer is spread over the intended site and allowed to absorb. For nasal or oral mucosa, a small amount is placed on the mucous membrane using a swab or applicator, following the prescriber's instructions.

The most serious risks include systemic toxicity such as seizures, cardiac arrhythmias, and severe allergic reactions like anaphylaxis. Methemoglobinemia and rare severe skin reactions (e.g., Stevens‑Johnson syndrome) may also occur, especially with extensive mucosal application or overdose.

Lidonostrum should be avoided in individuals with a known hypersensitivity to lidocaine or other amide‑type local anesthetics. Patients with severe heart block, significant conduction abnormalities, or those taking other sodium‑channel blocking drugs should use it only under strict medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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