Lidonostrum (Lidocaine Hydrochloride)

• Lidonostrum, a topical local anesthetic, acts on peripheral nerve endings to block pain transmission.
• Minor skin procedures: provides localized numbness to enable minor surgical or diagnostic interventions.
• Superficial pain and itching: reduces discomfort from irritant or inflammatory skin conditions.
• Minor burns and abrasions: alleviates pain and itching while supporting wound comfort.

• Lidocaine Hydrochloride reversibly blocks voltage‑gated sodium channels in neuronal membranes, inhibiting the initiation and propagation of nerve impulses. By stabilizing the neuronal membrane, it prevents depolarization and thus produces a localized loss of sensation without affecting systemic nerve function when applied topically.

Lidonostrum may cause a range of skin‑related reactions.

Common Side Effects

• Localized erythema or redness at the application site.
• Mild burning or stinging sensation during or after application.
• Pruritus (itching) around the treated area.
• Slight edema or swelling of the skin.

Serious or Rare Side Effects

• Allergic dermatitis or urticaria indicating hypersensitivity.
• Systemic toxicity presenting as dizziness, tinnitus, or CNS disturbances.
• Methemoglobinemia, a rare blood disorder affecting oxygen transport.
• Severe dermatitis or necrosis of the skin.
• Anaphylactic reaction requiring immediate medical attention.

• When using Lidonostrum, consider the following safety measures.
• Assess skin integrity: avoid application on broken, infected, or inflamed skin.
• Avoid excessive use: limit the amount and surface area to reduce systemic absorption.
• Monitor for allergic reactions: discontinue if signs of hypersensitivity appear.
• Use with caution in patients with cardiac conduction disorders.
• Do not combine with other topical anesthetics containing lidocaine without professional guidance.
• Store at ambient temperature: keep below 25 °C, in the original packaging, protected from moisture and direct sunlight.

Lidonostrum can interact with certain medications; awareness helps prevent adverse events.

Major Interactions (Avoid)

• Concurrent use with other lidocaine‑containing products: risk of cumulative systemic toxicity.
• Co‑administration with Class I antiarrhythmic agents (e.g., quinidine, procainamide): may enhance cardiac effects.
• Use with strong CYP450 inhibitors (e.g., cimetidine): increased lidocaine plasma levels.

Moderate Interactions (Monitor Closely)

• Application with epinephrine‑containing preparations: may prolong anesthetic effect.
• Use alongside occlusive dressings or other topical agents that increase skin absorption.