Product image of Lidoposterin (Lidocaine) supplied by GNH India

Lidoposterin

Active Ingredient:
Lidocaine
Origin:
EU

Lidoposterin (Lidocaine)

Lidocaine, the active ingredient in Lidoposterin, is a local anesthetic presented as a rectal formulation for rectal use. It provides topical analgesia for localized pain and is employed in certain anorectal procedures and conditions.
GNH India supplies Lidoposterin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Dr. Kade Pharmazeutische Fabrik Gmbh

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Indications & Clinical Uses

Lidoposterin is a lidocaine‑based product that acts on peripheral nerves to provide local anesthesia in the rectal area.

  • Anorectal surgery: supplies localized anesthesia to reduce procedural pain.
  • Hemorrhoidal disease: relieves discomfort associated with hemorrhoids.
  • Proctitis: alleviates inflammation‑related pain in the rectal mucosa.

How It Works

  • Lidocaine blocks voltage‑gated sodium channels on neuronal membranes, preventing the initiation and propagation of action potentials. By stabilizing the neuronal membrane, it inhibits the transmission of pain signals from the site of application, resulting in localized loss of sensation without affecting consciousness.

Side Effects

Lidoposterin may cause a range of adverse reactions, most of which are mild and related to local exposure.

Common Side Effects

  • Local irritation or burning sensation at the application site.
  • Numbness extending beyond the intended area.
  • Mild dizziness or headache.
  • Nausea or mild gastrointestinal upset.

Serious or Rare Side Effects

  • Allergic reactions such as rash, swelling, or anaphylaxis.
  • Methemoglobinemia, presenting as cyanosis or shortness of breath.
  • Central nervous system toxicity, including seizures or altered mental status.

Precautions & Warnings

Before using Lidoposterin, consider the following safety measures.

  • Assess allergy: verify that the patient has no known hypersensitivity to lidocaine or related amide anesthetics.
  • Monitor cardiac status: observe for arrhythmias in patients with pre‑existing heart disease.
  • Use with caution in hepatic impairment: lidocaine is metabolised by the liver and may accumulate.
  • Avoid excessive dose: adhere strictly to the prescriber's instructions.
  • Store at room temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Lidoposterin can interact with other medicines, requiring attention to avoid toxicity.

Major Interactions (Avoid)

  • Class I antiarrhythmics (e.g., quinidine, procainamide): may increase lidocaine toxicity.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole, erythromycin): can raise plasma lidocaine levels.
  • Beta‑blockers: may potentiate cardiac depressant effects.

Moderate Interactions (Monitor Closely)

  • Non‑steroidal anti‑inflammatory drugs: may increase local irritation.
  • Epinephrine: can alter lidocaine absorption and systemic exposure.
  • Concurrent use of other local anesthetics: additive toxicity risk.

Frequently Asked Questions

Lidoposterin is a lidocaine‑based rectal formulation used to provide local anesthesia and pain relief during anorectal procedures, for the treatment of hemorrhoidal discomfort, and to alleviate pain associated with proctitis. It works by numbing the rectal mucosa, helping patients tolerate examinations or minor surgeries with reduced discomfort.

Lidocaine blocks voltage‑gated sodium channels on nerve cells, preventing the rapid influx of sodium ions that initiates an action potential. This inhibition stops the transmission of pain signals along the affected nerves, resulting in a localized loss of sensation without affecting the patient's overall consciousness.

The appropriate dose of Lidoposterin is determined by the prescribing clinician based on the specific procedure, patient age, weight, and overall health status. Healthcare professionals calculate the amount needed to achieve effective anesthesia while minimizing the risk of systemic exposure.

Safety data for rectal lidocaine formulations in pregnancy and lactation are limited. Clinicians should weigh the potential benefits against possible risks and consider alternative analgesic options when treating pregnant or nursing patients, unless the therapeutic advantage clearly outweighs the uncertainty.

To order Lidoposterin, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Lidoposterin contains lidocaine, an amide‑type local anesthetic known for rapid onset and moderate duration of action. Compared with ester‑type agents such as procaine, lidocaine typically offers a faster onset, longer analgesic window, and a lower incidence of allergic reactions, making it a common choice for rectal applications.

Lidoposterin should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and direct light. Keep the product out of reach of children and avoid exposing it to extreme temperatures, which could affect its stability and efficacy.

Lidoposterin is administered rectally, typically as a suppository or gel applied directly to the rectal mucosa. The healthcare professional inserts the product according to the prescribed dosage, ensuring proper placement for optimal local anesthetic effect before the intended procedure or symptom relief.

Serious risks include systemic toxicity such as methemoglobinemia, severe allergic reactions (including anaphylaxis), central nervous system effects like seizures, and cardiac complications such as arrhythmias or profound hypotension. Prompt medical attention is required if any of these symptoms develop.

Patients with a known hypersensitivity to lidocaine or other amide‑type local anesthetics should avoid Lidoposterin. Individuals with severe hepatic impairment, certain cardiac conduction disorders, or those taking medications that significantly raise lidocaine plasma levels should also be evaluated carefully by a healthcare professional before use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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