Product image of Liferol (Formoterol Fumarate) supplied by GNH India

Liferol

Active Ingredient:
Formoterol Fumarate
Origin:
EU

Liferol (Formoterol Fumarate)

Formoterol Fumarate, the active ingredient in Liferol, is a long‑acting β2‑adrenergic agonist (LABA) presented as an inhalation formulation for inhalation use. It treats asthma and chronic obstructive pulmonary disease (COPD) in adult patients.
GNH India supplies Liferol as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Master Pharma S.R.L.

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Indications & Clinical Uses

  • Formoterol Fumarate is a bronchodilator that acts on the airway smooth‑muscle pathway to improve airflow in chronic respiratory diseases.
  • Asthma: improves bronchodilation and symptom control for maintenance therapy.
  • COPD: enhances lung function and reduces the frequency of exacerbations.
  • Exercise‑induced bronchoconstriction (as part of combination therapy): helps prevent bronchospasm during physical activity.

How It Works

  • Formoterol Fumarate selectively stimulates β2‑adrenergic receptors on airway smooth‑muscle cells, activating adenylate cyclase and increasing intracellular cyclic AMP. The rise in cAMP leads to relaxation of bronchial smooth muscle, producing sustained bronchodilation that improves airflow for several hours after inhalation.

Side Effects

Formoterol Fumarate may cause a range of adverse reactions, most of which are dose‑related and reversible.

Common Side Effects

  • Tremor: mild shaking of hands or limbs.
  • Headache: transient cranial discomfort.
  • Throat irritation: dryness or soreness after inhalation.
  • Cough: occasional irritation of the airway.
  • Palpitations: awareness of heartbeat.
  • Muscle cramps: occasional limb discomfort.

Serious or Rare Side Effects

  • Paradoxical bronchospasm: sudden worsening of breathing.
  • Tachycardia: rapid heart rate requiring medical attention.
  • Hypokalemia: low blood potassium levels.
  • Angina: chest pain indicative of cardiac strain.
  • Arrhythmias: irregular heart rhythms.
  • Hypersensitivity reactions: rash, swelling, or anaphylaxis.

Precautions & Warnings

  • Formoterol Fumarate requires careful patient assessment and monitoring to minimise risks.
  • Assess cardiovascular status: patients with arrhythmias or ischemic heart disease should be monitored closely.
  • Avoid abrupt discontinuation: sudden stopping may worsen asthma control.
  • Use only as prescribed: overuse can increase the likelihood of adverse cardiac events.
  • Do not combine with monoamine oxidase inhibitors: may precipitate severe hypertension.
  • Pregnancy and lactation: safety not established; use only if the benefit outweighs potential risk.
  • Store at ambient temperature: keep in the original container, protect from moisture and heat.

Avoid Interactions

Formoterol Fumarate can interact with several drug classes, requiring attention to avoid reduced efficacy or heightened toxicity.

Major Interactions (Avoid)

  • Beta‑blockers: may diminish bronchodilator effect and precipitate bronchospasm.
  • Monoamine oxidase inhibitors: risk of hypertensive crisis.
  • Diuretics: can exacerbate hypokalemia.

Moderate Interactions (Monitor Closely):\n- Other long‑acting β2‑agonists: additive cardiovascular stimulation may increase tachycardia risk.

  • Anticholinergic bronchodilators: combined use may cause excessive bronchodilation and tachyarrhythmias.

Frequently Asked Questions

Liferol contains formoterol fumarate, a long‑acting β2‑adrenergic agonist indicated for maintenance treatment of asthma and chronic obstructive pulmonary disease (COPD) in adult patients. It helps keep the airways open and reduces the frequency of symptoms such as wheezing and shortness of breath.

Formoterol fumarate selectively binds to β2‑adrenergic receptors on airway smooth‑muscle cells, activating adenylate cyclase and raising cyclic AMP levels. The increase in cAMP causes relaxation of the smooth muscle, leading to prolonged bronchodilation that improves airflow for up to 12 hours after inhalation.

The dose of Liferol is individualized by the prescribing healthcare professional based on the patient’s disease severity, age, and response to therapy. The prescriber determines the number of inhalations per day and the specific inhaler device to be used.

Safety data for formoterol fumarate in pregnancy and lactation are limited. It should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision should be made in consultation with a qualified healthcare provider.

To order Liferol, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Liferol (formoterol) is a long‑acting β2‑agonist that provides sustained bronchodilation for up to 12 hours, whereas short‑acting agents such as albuterol act for a few hours. Compared with other LABAs like salmeterol, formoterol has a faster onset of action while maintaining a similar duration, making it suitable for both maintenance and rescue use under medical guidance.

Liferol should be stored at ambient temperature, below 25 °C, in its original packaging. Keep the inhaler away from moisture, direct sunlight, and heat sources to preserve drug potency and device functionality.

Liferol is delivered via an inhalation device. The patient inhales the prescribed number of puffs through the mouthpiece, ensuring a slow, deep breath to allow the medication to reach the lower airways. Proper technique should be demonstrated by a healthcare professional before regular use.

Serious risks include paradoxical bronchospasm, which can worsen breathing, and cardiovascular effects such as tachycardia, arrhythmias, or angina. Patients should seek immediate medical attention if they experience sudden shortness of breath, chest pain, rapid heartbeat, or signs of an allergic reaction.

Liferol is contraindicated in patients with known hypersensitivity to formoterol fumarate or any component of the inhaler. It should also be avoided in individuals with severe cardiovascular disorders, uncontrolled hypertension, or those taking non‑selective β‑blockers unless directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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