Product image of Ligion (Tadalafil) supplied by GNH India

Ligion

Active Ingredient:
Tadalafil
Origin:
EU

Ligion (Tadalafil)

Tadalafil, the active ingredient in Ligion, is a phosphodiesterase type 5 (PDE5) inhibitor presented as an oral tablet for oral use. It treats erectile dysfunction and is also indicated for benign prostatic hyperplasia and pulmonary arterial hypertension in adult males.

GNH India supplies Ligion as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Gap S.A.

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Indications & Clinical Uses

Ligion (tadalafil) is used in conditions related to the nitric‑oxide/cGMP pathway that affect vascular smooth muscle tone.

  • Erectile dysfunction: improves the ability to achieve and maintain an erection suitable for sexual activity.
  • Benign prostatic hyperplasia: reduces lower urinary tract symptoms such as urinary frequency and urgency.
  • Pulmonary arterial hypertension: enhances exercise capacity by lowering pulmonary vascular resistance.

How It Works

  • Tadalafil selectively inhibits phosphodiesterase type 5, the enzyme responsible for degrading cyclic guanosine monophosphate (cGMP) in smooth muscle cells. By preserving cGMP levels, it promotes nitric‑oxide‑mediated relaxation of vascular smooth muscle, particularly in the corpus cavernosum, pulmonary vasculature, and prostatic tissue, leading to increased blood flow and reduced pressure.

Side Effects

Adverse reactions may occur with tadalafil therapy.

Common Side Effects

  • Headache
  • Flushing
  • Dyspepsia
  • Nasal congestion

Serious or Rare Side Effects

  • Sudden vision loss (non‑arteritic anterior ischemic optic neuropathy)
  • Priapism lasting longer than four hours
  • Severe hypotension or syncope

Precautions & Warnings

Before using Ligion, consider the following safety measures.

  • Cardiovascular assessment: evaluate for recent myocardial infarction or unstable angina.
  • Concomitant nitrate therapy: avoid due to risk of profound hypotension.
  • Severe hepatic or renal impairment: dose adjustment may be required.
  • Visual or auditory disturbances: discontinue and seek medical attention if they occur.
  • Allergic reactions: stop the drug if signs of hypersensitivity develop.
  • Store at room temperature: keep in the original container, protect from moisture and heat.

Avoid Interactions

Tadalafil can interact with several medication classes.

Major Interactions (Avoid)

  • Nitrates (e.g., nitroglycerin): risk of severe hypotension.
  • Guanylate cyclase stimulators (e.g., riociguat): additive vasodilatory effect.
  • Potent CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): may increase tadalafil exposure.

Moderate Interactions (Monitor Closely)

  • Antihypertensive agents: possible additive blood pressure lowering.
  • CYP3A4 inducers (e.g., rifampin, carbamazepine): may reduce efficacy of tadalafil.

Frequently Asked Questions

Ligion contains tadalafil, which is prescribed for erectile dysfunction, benign prostatic hyperplasia, and pulmonary arterial hypertension. In each case the drug works by improving blood flow in the relevant vascular beds, helping to restore normal function.

Tadalafil blocks the phosphodiesterase type 5 enzyme, preventing the breakdown of cyclic guanosine monophosphate (cGMP). Higher cGMP levels cause smooth‑muscle relaxation and vasodilation, which enhances blood flow to the penis, prostate, and pulmonary arteries.

The specific dose of Ligion is determined by a qualified prescriber based on the patient’s condition, response, and any concomitant medications. Physicians tailor the regimen to achieve the desired therapeutic effect while minimizing risk.

Tadalafil is not recommended for use in pregnancy or while breastfeeding because safety data are lacking. Women who are pregnant, planning to become pregnant, or nursing should avoid the medication unless a doctor determines that the benefit outweighs potential risks.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Ligion (tadalafil) has a longer half‑life than sildenafil or vardenafil, allowing for once‑daily dosing for BPH or a longer therapeutic window for erectile dysfunction. The choice between agents depends on patient preference, dosing schedule, and individual response.

Ligion should be stored at room temperature, below 25 °C, in its original packaging. Keep the product away from moisture, direct sunlight, and excessive heat to maintain its stability and potency.

Ligion is taken orally with water. It can be taken with or without food, but a consistent routine helps maintain predictable absorption. Patients should follow the dosing schedule prescribed by their healthcare provider.

Serious risks include sudden vision loss (non‑arteritic anterior ischemic optic neuropathy), prolonged erection lasting more than four hours (priapism), and severe hypotension, especially when combined with nitrates. Immediate medical attention is required if any of these events occur.

Ligion should not be used by individuals taking nitrates, those with severe uncontrolled hypertension, recent heart attack or stroke, or patients with known hypersensitivity to tadalafil or any of the tablet’s excipients. A healthcare professional should evaluate suitability before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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