Product image of Lignocain B. Braun Melsungen (Lidocaine Hydrochloride Monohydrate) supplied by GNH India

Lignocain B. Braun Melsungen

Active Ingredient:
Lidocaine Hydrochloride Monohydrate
Origin:
EU

Lignocain B. Braun Melsungen (Lidocaine Hydrochloride Monohydrate)

Lidocaine, the active ingredient in Lignocain, is a local anesthetic presented as a sterile solution for epidural, intradermal, and intravenous use. It provides rapid, reversible loss of sensation to facilitate minor surgical procedures, epidural analgesia, intravenous regional anesthesia, and intradermal skin testing.
GNH India supplies Lignocain as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

B.Braun Melsungen Ag

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Indications & Clinical Uses

Lignocain is a local anesthetic that blocks nerve impulse transmission in targeted tissues.

  • Minor surgical procedures: provides localized numbness to enable pain‑free incisions and manipulation.
  • Epidural analgesia: delivers segmental anesthesia for labor, postoperative pain control, or chronic pain management.
  • Intravenous regional anesthesia (Bier block): produces temporary limb anesthesia for short surgical interventions.
  • Intradermal skin testing: creates a controlled area of numbness to assess hypersensitivity reactions.

How It Works

  • Lidocaine blocks voltage‑gated sodium channels on neuronal membranes, preventing the influx of sodium ions required for depolarization. This inhibition stops the initiation and propagation of action potentials, resulting in reversible loss of sensation in the administered area without affecting surrounding tissues.

Side Effects

Lignocain may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Tingling or numbness at the injection site
  • Mild dizziness or light‑headedness
  • Nausea or vomiting
  • Transient headache
  • Localized swelling or erythema

Serious or Rare Side Effects

  • Cardiac arrhythmias or conduction disturbances
  • Seizures or central nervous system depression
  • Respiratory depression or apnea
  • Severe allergic reactions including anaphylaxis
  • Methemoglobinemia in susceptible individuals

Precautions & Warnings

When using Lignocain, clinicians should observe several safety measures.

  • Assess patient allergy: verify no known hypersensitivity to lidocaine or amide‑type anesthetics.
  • Monitor cardiac function: observe ECG and blood pressure during high‑dose epidural or intravenous administration.
  • Use lowest effective concentration: adjust dose to achieve desired anesthesia while minimizing systemic exposure.
  • Avoid in severe hepatic impairment: reduced metabolism may increase toxicity risk.
  • Store at room temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Lignocain can interact with other medications, altering its safety profile.

Major Interactions (Avoid)

  • Class I antiarrhythmics (e.g., quinidine, procainamide): may potentiate cardiotoxicity.
  • Beta‑blockers (e.g., propranolol) combined with high‑dose lidocaine: increased risk of severe bradycardia and conduction block.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inhibitors (e.g., erythromycin, clarithromycin): can raise plasma lidocaine levels.
  • CYP1A2 inducers (e.g., carbamazepine, smoking): may reduce therapeutic effect.
  • Concurrent use of other local anesthetics: cumulative toxicity risk, especially with large total doses.

Frequently Asked Questions

Lignocain is a lidocaine‑based injectable solution used to provide local anesthesia for minor surgical procedures, epidural analgesia during labor or postoperative pain control, intravenous regional (Bier) blocks for short‑duration limb surgeries, and intradermal skin testing to assess hypersensitivity reactions.

Lidocaine blocks voltage‑gated sodium channels on nerve membranes, preventing sodium influx that is essential for action potential generation. This interruption stops nerve impulse propagation, producing a reversible loss of sensation in the area where the drug is administered.

The specific dose of Lignocain is determined by the prescribing clinician based on the intended procedure, patient weight, age, and clinical condition. Healthcare professionals calculate the appropriate concentration and volume to achieve effective anesthesia while minimizing systemic exposure.

Safety data for lidocaine in pregnancy and lactation are limited. It is classified as a Category B drug in many regions, indicating no proven risk in animal studies but insufficient human data. Use during pregnancy or while breastfeeding should only occur when the potential benefit outweighs any possible risk, as decided by the treating physician.

To order Lignocain, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Lignocain (lidocaine) offers a rapid onset of action (1–3 minutes) and moderate duration (30–120 minutes) compared with agents like bupivacaine, which has a slower onset but longer duration. Lidocaine’s favorable safety profile and versatility for multiple routes (epidural, intradermal, intravenous) make it a common first‑line choice for short‑ to medium‑duration procedures.

Lignocain should be stored at room temperature, preferably below 25 °C, in its original sealed container. Protect the solution from direct sunlight, excessive heat, and moisture. Do not freeze. Inspect the vial for particulate matter or discoloration before use, and discard any product that appears compromised.

Lignocain is administered by a qualified healthcare professional via injection. The route—epidural, intradermal, or intravenous—depends on the clinical indication. Proper aseptic technique, correct needle placement, and dosage calculation are essential to achieve effective anesthesia and reduce the risk of systemic toxicity.

Serious risks include cardiovascular toxicity such as arrhythmias, heart block, or cardiac arrest, and central nervous system toxicity leading to seizures or respiratory depression. Rare but severe allergic reactions (anaphylaxis) and methemoglobinemia can also occur, especially in patients with pre‑existing enzyme deficiencies.

Lignocain is contraindicated in patients with a known hypersensitivity to lidocaine or other amide‑type local anesthetics, as well as in individuals with severe hepatic impairment that could impair drug metabolism. Caution is also advised for patients with significant cardiac conduction disorders or those taking interacting medications listed under major interactions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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