Product image of Lignocainum Hydrochloricum Wzf (Lidocaine Hydrochloride Monohydrate) supplied by GNH India

Lignocainum Hydrochloricum Wzf

Active Ingredient:
Lidocaine Hydrochloride Monohydrate
Origin:
EU

Lignocainum Hydrochloricum Wzf (Lidocaine Hydrochloride Monohydrate)

Lidocaine hydrochloride, the active ingredient in Lignocainum Hydrochloricum Wzf, is a local anesthetic presented as a sterile solution for epidural, infiltration, and intrathecal use. It provides reversible nerve block for procedures that require regional anesthesia in adult patients.

GNH India supplies Lignocainum Hydrochloricum Wzf as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Zaklady Farmaceutyczne Polpharma S.A.

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Indications & Clinical Uses

Lignocainum Hydrochloricum Wzf is a local anesthetic used in procedures that involve regional nerve blockade.

  • Epidural procedures: provides local anesthesia for pain control during epidural administration.
  • Infiltration procedures: creates a temporary loss of sensation in targeted tissue for minor surgeries or diagnostic work.
  • Intrathecal procedures: delivers spinal anesthesia to facilitate surgeries or pain management interventions.

How It Works

  • Lidocaine hydrochloride blocks voltage‑gated sodium channels on neuronal membranes, preventing the initiation and propagation of action potentials. This reversible inhibition reduces nerve impulse transmission, resulting in loss of sensation in the area where the drug is administered.

Side Effects

Lignocainum Hydrochloricum Wzf may cause a range of adverse reactions following administration.

Common Side Effects

  • Tingling or numbness at the injection site.
  • Metallic taste in the mouth.
  • Light‑headedness or dizziness.
  • Mild hypotension.
  • Transient visual disturbances.

Serious or Rare Side Effects

  • Seizures or convulsions.
  • Cardiac arrhythmias, including ventricular tachycardia.
  • Severe hypotension or cardiovascular collapse.
  • Allergic reactions such as rash, bronchospasm, or anaphylaxis.
  • Central nervous system depression leading to respiratory compromise.

Precautions & Warnings

When using Lignocainum Hydrochloricum Wzf, clinicians should observe several safety measures.

  • Assess patient allergy: verify no known hypersensitivity to lidocaine or amide‑type anesthetics.
  • Monitor cardiovascular status: watch for hypotension, bradycardia, or arrhythmias during and after injection.
  • Use the lowest effective dose: limit exposure to reduce risk of systemic toxicity.
  • Avoid intravascular injection: aspirate before administration to prevent rapid systemic absorption.
  • Use caution in hepatic impairment: reduced metabolism may increase plasma levels.
  • Store at room temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Lignocainum Hydrochloricum Wzf can interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • Class I antiarrhythmics (e.g., quinidine, procainamide): increase risk of systemic lidocaine toxicity.
  • Beta‑blockers (e.g., propranolol): may enhance cardiotoxic effects of lidocaine.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole): raise plasma lidocaine concentrations.

Moderate Interactions (Monitor Closely)

  • Alpha‑2 agonists (e.g., clonidine): additive hypotensive effect.
  • General anesthetics (e.g., propofol): may potentiate central nervous system depression.
  • Loop diuretics (e.g., furosemide): may alter lidocaine clearance and plasma levels.

Frequently Asked Questions

Lignocainum Hydrochloricum Wzf is a sterile lidocaine hydrochloride preparation employed as a local anesthetic for epidural, infiltration, and intrathecal procedures. It provides reversible nerve block to facilitate surgeries, diagnostic interventions, and pain‑control techniques in adult patients.

Lidocaine blocks voltage‑gated sodium channels on neuronal membranes, preventing the initiation and propagation of action potentials. This reversible inhibition stops nerve impulse transmission, producing a temporary loss of sensation in the area where the drug is administered.

The dose of Lignocainum Hydrochloricum Wzf is determined by the prescribing clinician based on the specific procedure, patient characteristics, and regulatory guidelines. Healthcare professionals calculate the appropriate volume and concentration to achieve effective anesthesia while minimizing toxicity.

Safety data for lidocaine use in pregnancy and lactation are limited. It may be used only when the potential benefit to the mother outweighs any possible risk to the fetus or infant. Clinicians should evaluate each case individually and consider alternative options when appropriate.

To place an order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams across international markets. After verification of trade or institutional credentials, the sales team will provide pricing, availability, shipping details (including cold‑chain if needed), and import documentation.

Lidocaine offers a rapid onset of action and moderate duration, making it suitable for many regional techniques. Compared with bupivacaine, which has a longer duration but slower onset, lidocaine is preferred when a quicker block is needed. Choice of agent depends on procedural length, desired depth of anesthesia, and patient‑specific factors.

Store the product at room temperature, preferably below 25 °C, in its original sealed container. Protect it from moisture, direct sunlight, and extreme temperature fluctuations. Do not freeze the solution, and ensure the vial is kept upright to avoid contamination.

The drug is administered by qualified healthcare professionals via epidural, infiltration, or intrathecal injection. Proper aseptic technique, correct needle placement, and aspiration before injection are essential to avoid intravascular delivery and to achieve effective regional anesthesia.

Serious risks include systemic toxicity leading to seizures, cardiac arrhythmias such as ventricular tachycardia, severe hypotension, and rare allergic reactions like anaphylaxis. Prompt recognition and management of these events are critical, and resuscitation equipment should be readily available during administration.

Patients with a known hypersensitivity to lidocaine or other amide‑type local anesthetics should avoid this product. It is also contraindicated in individuals with severe hepatic impairment, certain cardiac conduction disorders, or those taking medications that significantly increase lidocaine plasma levels without appropriate monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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