Product image of Lignospan (Epinephrine Bitartrate, Lidocaine Hydrochloride) supplied by GNH India

Lignospan

Active Ingredient:
Epinephrine Bitartrate, Lidocaine Hydrochloride
Origin:
EU

Lignospan (Epinephrine Bitartrate, Lidocaine Hydrochloride)

Epinephrine Bitartrate and Lidocaine Hydrochloride, the active ingredients in Lignospan, are a local anesthetic presented as a dental formulation for intra‑oral use. They provide rapid onset anesthesia, vasoconstriction to limit bleeding, and prolonged pain control during dental procedures.

GNH India supplies Lignospan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Septodont Nv-Sa

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Lignospan is used in dentistry to achieve local anesthesia and hemostasis.

  • Dental anesthesia: produces profound numbness of the targeted oral tissues for routine extractions and restorations.
  • Pain control during dental procedures: reduces procedural discomfort and improves patient tolerance.
  • Minor oral surgery: facilitates incision, tissue manipulation, and suturing with minimal bleeding.
  • Periodontal therapy: enhances comfort during scaling, root planing, and other periodontal interventions.

How It Works

  • Lidocaine blocks voltage‑gated sodium channels on neuronal membranes, preventing the initiation and propagation of nerve impulses. Epinephrine bitartrate stimulates alpha‑adrenergic receptors on vascular smooth muscle, causing vasoconstriction that prolongs lidocaine’s anesthetic effect, reduces systemic absorption, and limits intra‑oral bleeding during dental work.

Side Effects

Adverse reactions may occur with any local anesthetic containing epinephrine.

Common Side Effects

  • Injection site pain: mild discomfort at the site of administration.
  • Local swelling or bruising: transient tissue edema.
  • Taste alteration: temporary metallic or bitter sensation.
  • Headache: mild to moderate intensity.
  • Dizziness or light‑headedness: usually resolves quickly.
  • Nausea: occasional mild upset stomach.

Serious or Rare Side Effects

  • Allergic reaction: rash, itching, or anaphylaxis requiring immediate medical attention.
  • Cardiovascular events: hypertension, tachycardia, or arrhythmias.
  • Seizures: rare central nervous system excitation.
  • Prolonged numbness: lasting beyond the expected duration.
  • Tissue necrosis: due to excessive vasoconstriction.
  • Methemoglobinemia: very rare hemoglobin oxidation disorder.

Precautions & Warnings

Before using Lignospan, consider patient‑specific safety factors.

  • Allergy assessment: confirm no known hypersensitivity to lidocaine, epinephrine, or related compounds.
  • Cardiovascular disease: use with caution in patients with ischemic heart disease, arrhythmias, or uncontrolled hypertension.
  • Thyroid disorders: avoid in patients with hyperthyroidism or pheochromocytoma.
  • Drug interactions: review concomitant medications that may potentiate epinephrine effects.
  • Dosage limits: adhere to recommended maximum lidocaine dose for dental procedures.
  • Store at room temperature: keep in original container, protect from moisture and direct light.

Avoid Interactions

Lignospan may interact with several systemic agents.

Major Interactions (Avoid)

  • Non‑selective beta‑blockers: can enhance epinephrine‑induced hypertension and tachycardia.
  • Monoamine oxidase inhibitors (MAOIs): increase risk of hypertensive crisis when combined with epinephrine.
  • Tricyclic antidepressants: may potentiate cardiovascular stimulation.

Moderate Interactions (Monitor Closely)

  • Antihypertensive drugs (e.g., ACE inhibitors, calcium channel blockers): may blunt desired vasoconstriction, requiring dose adjustment.
  • Other local anesthetics: cumulative lidocaine dose should not exceed safety limits.
  • Caffeine or sympathomimetic agents: may augment epinephrine’s systemic effects.

Frequently Asked Questions

Lignospan is a dental anesthetic formulation that combines epinephrine bitartrate and lidocaine hydrochloride to provide rapid local numbness and vasoconstriction. It is used to control pain and reduce bleeding during a variety of dental procedures, including extractions, restorations, and minor oral surgeries.

Lidocaine blocks voltage‑gated sodium channels on nerve fibers, preventing the transmission of pain signals. Epinephrine bitartrate activates alpha‑adrenergic receptors on blood vessels, causing vasoconstriction. This reduces blood flow at the injection site, prolongs lidocaine’s anesthetic effect, and minimizes intra‑oral bleeding.

The specific dose of Lignospan is determined by the prescribing dentist or oral surgeon based on the procedure, patient size, and clinical judgment. Healthcare professionals calculate the appropriate volume to achieve effective anesthesia while staying within safe lidocaine limits.

Safety data for Lignospan in pregnancy and lactation are limited. It should only be used when clearly needed, and the prescriber must weigh potential benefits against possible risks. Consultation with an obstetrician or pediatrician is recommended before administration to pregnant or nursing individuals.

To order Lignospan, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Lignospan combines lidocaine with epinephrine, offering faster onset and longer duration than lidocaine alone. Compared with other anesthetic agents such as articaine or mepivacaine, it provides reliable hemostasis due to the vasoconstrictive action of epinephrine, making it especially useful for procedures where bleeding control is critical.

Lignospan should be stored at room temperature, below 25 °C, in its original packaging. Protect the product from moisture, direct sunlight, and extreme temperature fluctuations. Do not freeze or expose the solution to excessive heat, as this may affect potency.

Lignospan is administered by a dental professional via intra‑oral injection. The solution is injected into the mucosal tissue or near the target nerve using a sterile syringe and appropriate gauge needle. Proper aseptic technique and dosage calculation are essential for safe and effective anesthesia.

Serious risks include allergic reactions such as anaphylaxis, cardiovascular events like hypertension, tachycardia, or arrhythmias, and rare neurological effects such as seizures. Immediate medical attention is required if any signs of severe reaction, chest pain, or prolonged numbness occur.

Lignospan should be avoided in patients with known hypersensitivity to lidocaine, epinephrine, or any component of the formulation. It is also contraindicated in individuals with uncontrolled hypertension, severe cardiac disease, hyperthyroidism, or pheochromocytoma, unless the prescriber determines that benefits outweigh risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Related Products

Other formulations containing Epinephrine Bitartrate, Lidocaine Hydrochloride

A

A
A

A
A

A
A

A

Browse all products →

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Regulatory recognitions

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.

SGS GSDP Certification

GSDP Compliant from SGS

URS ISO 9001

URS ISO 9001 Certification

FDA Maharashtra

Licensed by FDA Maharashtra

IEC License DGFT

IEC License issued by DGFT