Product image of Lignospan Special (Epinephrine, Anhydrous Lidocaine Hydrochloride) supplied by GNH India

Lignospan Special

Active Ingredient:
Epinephrine, Anhydrous Lidocaine Hydrochloride
Origin:
EU

Lignospan Special (Epinephrine, Anhydrous Lidocaine Hydrochloride)

Lidocaine, the active ingredient in Lignospan Special, is a local anesthetic presented as a solution for injection for infiltration and perineural use. It provides rapid, reversible loss of sensation for dental, oral surgical, and peripheral nerve block procedures.
GNH India supplies Lignospan Special as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Septodont

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Indications & Clinical Uses

  • Lignospan Special, a combination of lidocaine and epinephrine, is used in the local anesthetic pathway for procedures requiring regional numbness.
  • Infiltration anesthesia: provides rapid onset numbness for minor surgical or diagnostic procedures.
  • Perineural nerve block: enables prolonged anesthesia for limb or peripheral nerve surgeries.
  • Dental and oral surgery: facilitates pain‑free extractions, restorations, and periodontal work.

How It Works

  • Lidocaine blocks voltage‑gated sodium channels in neuronal membranes, preventing initiation and propagation of nerve impulses, while epinephrine activates alpha‑adrenergic receptors causing local vasoconstriction, which reduces systemic absorption of lidocaine and prolongs its anesthetic effect.

Side Effects

Lignospan Special may cause a range of adverse reactions following injection.

Common Side Effects

  • Pain or burning at the injection site
  • Mild swelling or erythema
  • Dizziness or light‑headedness
  • Metallic taste in the mouth
  • Nausea or mild vomiting
  • Transient increase in heart rate

Serious or Rare Side Effects

  • Allergic reaction including rash, itching, or anaphylaxis
  • Severe hypotension or hypertension
  • Cardiac arrhythmias or myocardial ischemia
  • Seizures due to systemic lidocaine toxicity
  • Methemoglobinemia
  • Prolonged numbness or motor block

Precautions & Warnings

  • Before using Lignospan Special, consider the following safety measures.
  • Allergy assessment: confirm no known hypersensitivity to lidocaine, epinephrine, or related compounds.
  • Cardiovascular status: use cautiously in patients with uncontrolled hypertension, arrhythmias, or severe coronary disease.
  • Dosage limits: avoid exceeding recommended maximum lidocaine dose to prevent systemic toxicity.
  • Concurrent medications: review use of other local anesthetics or drugs that affect cardiac conduction.
  • Pregnancy and lactation: weigh potential risks and benefits; data are limited.
  • Store below 25°C: keep in the original container, protect from moisture and light.

Avoid Interactions

Lignospan Special can interact with several drug classes; monitoring is essential.

Major Interactions (Avoid)

  • Beta‑blockers: may potentiate epinephrine‑induced tachycardia and hypertension.
  • Monoamine oxidase inhibitors (MAOIs): increased risk of hypertensive crisis.
  • Class I anti‑arrhythmic agents: additive cardiac toxicity.
  • Tricyclic antidepressants: heightened risk of arrhythmias.

Moderate Interactions (Monitor Closely)

  • Non‑selective NSAIDs: may increase bleeding tendency.
  • Other local anesthetics: cumulative systemic toxicity.
  • Diuretics: can alter plasma lidocaine concentrations.
  • Calcium channel blockers: may affect cardiac response to epinephrine.

Frequently Asked Questions

Lignospan Special is a sterile solution containing lidocaine and epinephrine that provides local anesthesia for infiltration, perineural nerve blocks, and dental or oral surgical procedures. It is administered by a qualified healthcare professional to achieve rapid, reversible loss of sensation in the targeted area.

Lidocaine blocks voltage‑gated sodium channels on neuronal membranes, preventing the initiation and propagation of nerve impulses. This interruption of signal transmission results in loss of sensation in the area where the drug is injected.

The dose of Lignospan Special is determined by the prescribing clinician based on the procedure, patient size, and clinical judgment. Only a qualified healthcare professional should calculate and administer the appropriate amount.

Safety data for Lignospan Special in pregnancy and lactation are limited. The product should only be used when the potential benefit justifies any potential risk to the fetus or infant, and the decision should be made by the treating physician.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and import documentation.

Lignospan Special combines lidocaine with epinephrine, offering faster onset and longer duration than lidocaine alone. The epinephrine component reduces systemic absorption, allowing higher local concentrations while minimizing toxicity, which can be advantageous over plain lidocaine or other anesthetics without vasoconstrictors.

Store the solution below 25 °C in its original packaging, protecting it from moisture and direct light. Do not freeze. Inspect the vial for particulate matter or discoloration before use, and discard if the seal is compromised.

Lignospan Special is administered by a trained professional via infiltration or perineural injection. The solution is injected directly into the tissue or around a nerve using a sterile syringe and appropriate needle size, following aseptic technique.

Serious risks include allergic reactions (anaphylaxis), severe cardiovascular events such as hypertension, arrhythmias, or myocardial ischemia, and systemic lidocaine toxicity leading to seizures or cardiac depression. Immediate medical attention is required if any of these occur.

Patients with known hypersensitivity to lidocaine, epinephrine, or any component of the formulation should avoid Lignospan Special. It is also contraindicated in individuals with severe uncontrolled hypertension, certain cardiac conduction disorders, or those taking MAO inhibitors without careful medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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