Product image of Lignospan Special (Epinephrine, Anhydrous Lidocaine Hydrochloride) supplied by GNH India

Lignospan Special

Active Ingredient:
Epinephrine, Anhydrous Lidocaine Hydrochloride
Origin:
EU

Lignospan Special (Epinephrine, Anhydrous Lidocaine Hydrochloride)

Lidocaine hydrochloride (anhydrous), the active ingredient in Lignospan Special, is a local anesthetic presented as a solution for infiltration, perineural, or submucosal use. It provides rapid onset anesthesia and, together with epinephrine, prolongs the effect for dental, minor surgical and diagnostic procedures.\n\nGNH India supplies Lignospan Special as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Septodont Nv-Sa

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Indications & Clinical Uses

  • Lignospan Special, a combination of lidocaine and epinephrine, provides local anesthesia for procedures requiring nerve block or tissue infiltration.\n\n- Dental procedures: delivers rapid and prolonged numbness for extractions, restorations and periodontal work.\n- Minor surgical procedures: enables pain‑free excision, biopsy or suturing of soft tissues.\n- Diagnostic procedures: facilitates patient comfort during endoscopic, mucosal or perineural sampling.

How It Works

  • Lidocaine blocks voltage‑gated sodium channels on neuronal membranes, preventing depolarisation and impulse transmission. Epinephrine activates α‑ and β‑adrenergic receptors, causing vasoconstriction at the injection site, which reduces systemic absorption of lidocaine, prolongs its anesthetic duration, and limits bleeding.

Side Effects

  • Adverse reactions may occur following administration of Lignospan Special.\n\nCommon Side Effects:\n- Transient burning or stinging at the injection site.\n- Mild dizziness or light‑headedness.\n- Temporary numbness extending beyond the intended area.\n- Minor swelling or bruising around the injection site.\n\nSerious or Rare Side Effects:\n- Allergic reactions such as rash, urticaria, or anaphylaxis.\n- Cardiovascular events including hypertension, tachycardia, or arrhythmias due to epinephrine.\n- Central nervous system toxicity presenting as seizures or loss of consciousness.

Precautions & Warnings

  • When using Lignospan Special, consider the following safety measures.\n\n- Allergy assessment: confirm no known hypersensitivity to lidocaine, epinephrine or related compounds.\n- Cardiac conditions: avoid in patients with uncontrolled hypertension, arrhythmias or severe coronary disease.\n- Drug interactions: review concomitant medications that may potentiate epinephrine effects.\n- Dosage limits: adhere to maximum recommended lidocaine dose to prevent systemic toxicity.\n- Pediatric use: adjust dose carefully and monitor closely.\n- Store at room temperature: keep below 25°C, in original container, protected from moisture and light.

Avoid Interactions

  • Lignospan Special may interact with other medicines; monitor patients accordingly.\n\nMajor Interactions (Avoid):\n- Monoamine oxidase inhibitors (MAOIs): risk of hypertensive crisis with epinephrine.\n- Class I anti‑arrhythmic agents (e.g., quinidine, procainamide): may increase lidocaine plasma levels.\n\nModerate Interactions (Monitor Closely):\n- β‑blockers: may potentiate bradycardia or hypotension when combined with epinephrine.\n- Non‑steroidal anti‑inflammatory drugs (NSAIDs): may increase bleeding risk despite vasoconstriction.\n- Tricyclic antidepressants: can raise lidocaine concentrations, requiring dose adjustment.

Frequently Asked Questions

Lignospan Special is a combination of lidocaine and epinephrine used to provide local anesthesia for dental work, minor surgical interventions, and diagnostic procedures that require infiltration, perineural, or submucosal injection. The epinephrine component prolongs the anesthetic effect and reduces bleeding at the site.

Lidocaine blocks voltage‑gated sodium channels on nerve membranes, preventing the initiation and propagation of action potentials. This interruption stops pain signals from reaching the brain, resulting in a rapid loss of sensation in the targeted area.

The appropriate dose of Lignospan Special is determined by the prescribing clinician based on the procedure, patient size, and site of administration. Healthcare professionals calculate the amount needed to stay within safe lidocaine limits and to achieve the desired duration of anesthesia.

Safety data for Lignospan Special in pregnancy and lactation are limited, and the product is classified as pregnancy category unknown. Clinicians should weigh potential benefits against risks and consider alternative anesthetic options when treating pregnant or nursing patients.

To order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and any required import documentation.

Compared with lidocaine alone, Lignospan Special adds epinephrine, which causes local vasoconstriction. This prolongs the anesthetic duration, reduces systemic absorption, and minimizes intra‑procedural bleeding, making it preferable for longer or more vascular procedures.

Store Lignospan Special at room temperature, below 25 °C, in its original packaging. Protect the container from moisture, direct sunlight and extreme temperature fluctuations to maintain product stability and potency.

The product is supplied as a sterile solution for injection. It is administered by infiltration, perineural, or submucosal injection using standard aseptic techniques, allowing the clinician to target the specific tissue or nerve requiring anesthesia.

Serious risks include allergic reactions such as anaphylaxis, cardiovascular events like hypertension, tachycardia or arrhythmias due to epinephrine, and central nervous system toxicity (e.g., seizures) from excessive lidocaine absorption. Immediate medical attention is required if these occur.

Patients with known hypersensitivity to lidocaine, epinephrine, or any component of the formulation should avoid it. It is also contraindicated in individuals with severe uncontrolled hypertension, significant cardiac arrhythmias, or those taking monoamine oxidase inhibitors.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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