Product image of Linagliptin/Metformin Stada (Metformin Hydrochloride, Linagliptin) supplied by GNH India

Linagliptin/Metformin Stada

Active Ingredient:
Metformin Hydrochloride, Linagliptin
Origin:
EU

Linagliptin/Metformin Stada (Metformin Hydrochloride, Linagliptin)

Linagliptin/Metformin, the active ingredient in Linagliptin/Metformin Stada, is a DPP‑4 inhibitor / Biguanide presented as an oral tablet for oral use. It is indicated for the management of type 2 diabetes mellitus in adults.
GNH India supplies Linagliptin/Metformin Stada as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Stada Arzneimittel Ag

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Indications & Clinical Uses

Linagliptin/Metformin is an oral antidiabetic combination that targets hyperglycaemia in type 2 diabetes.

  • Type 2 diabetes mellitus: lowers fasting and post‑prandial glucose levels.
  • Inadequate control on metformin alone: adds DPP‑4 inhibition to improve glycaemic control.
  • Combination with other oral antidiabetics: provides complementary mechanisms to achieve target HbA1c.

How It Works

  • Linagliptin selectively inhibits dipeptidyl peptidase‑4, prolonging the activity of incretin hormones (GLP‑1 and GIP) and enhancing glucose‑dependent insulin secretion. Metformin decreases hepatic gluconeogenesis and increases peripheral insulin sensitivity, together producing a synergistic reduction in blood glucose.

Side Effects

Adverse reactions may occur with Linagliptin/Metformin therapy.

Common Side Effects

  • Nausea
  • Diarrhoea
  • Abdominal discomfort
  • Headache
  • Upper respiratory tract infection
  • Mild hypoglycaemia (when combined with sulfonylureas or insulin)

Serious or Rare Side Effects

  • Lactic acidosis (metformin‑related)
  • Acute pancreatitis
  • Severe allergic reactions (e.g., angio‑edema, Stevens‑Johnson syndrome)
  • Hepatic dysfunction
  • Significant renal impairment
  • Severe hypoglycaemia requiring assistance

Precautions & Warnings

Before initiating therapy, consider the following precautions.

  • Renal function assessment: evaluate eGFR to determine suitability.
  • Hepatic impairment: use with caution in patients with liver disease.
  • Risk of lactic acidosis: avoid in patients with conditions predisposing to hypoxia.
  • Concomitant hypoglycaemic agents: monitor for additive glucose‑lowering effect.
  • Pregnancy and lactation: assess risk‑benefit ratio; use only if clearly needed.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Linagliptin/Metformin may interact with several medicines.

Major Interactions (Avoid)

  • Iodinated contrast media: suspend metformin to prevent lactic acidosis.
  • Insulin or sulfonylureas: increased risk of severe hypoglycaemia.
  • Strong CYP3A4 inhibitors: may raise linagliptin plasma levels.

Moderate Interactions (Monitor Closely)

  • Diuretics: can affect renal clearance of metformin.
  • Beta‑blockers: may mask hypoglycaemia symptoms.
  • ACE inhibitors/ARBs: monitor renal function and electrolytes.

Frequently Asked Questions

Linagliptin/Metformin Stada is prescribed to improve blood‑glucose control in adults with type 2 diabetes mellitus, usually as part of a comprehensive plan that includes diet and exercise.

Linagliptin blocks the enzyme dipeptidyl peptidase‑4, which prolongs the action of incretin hormones, thereby increasing insulin secretion and decreasing glucagon release in a glucose‑dependent manner.

The specific dose and dosing schedule are determined by the prescribing clinician based on individual patient factors such as renal function, glycaemic targets, and concomitant therapies.

Safety in pregnancy and lactation has not been fully established. The drug should only be used if the potential benefit justifies the potential risk to the fetus or infant, and under close medical supervision.

Submit an enquiry on the product page at gnhindia.com, indicating the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Compared with metformin alone, the addition of linagliptin offers DPP‑4 inhibition, which can provide greater HbA1c reduction without the weight gain often seen with sulfonylureas, and it has a low risk of hypoglycaemia when used without insulin or sulfonylureas.

Store the product at ambient temperature, below 25 °C, in the original packaging and protect it from moisture and direct sunlight to maintain stability.

The medication is taken orally, usually with meals, as a whole tablet. Patients should follow the prescriber’s instructions regarding timing and whether it should be taken with food.

Serious risks include lactic acidosis (especially in patients with renal impairment), severe hypoglycaemia when combined with insulin or sulfonylureas, acute pancreatitis, and rare allergic reactions such as angio‑edema.

Patients with severe renal impairment (eGFR < 30 mL/min/1.73 m²), known hypersensitivity to either component, or those with a history of lactic acidosis should avoid this medication.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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