Product image of Linatil Comp (Enalapril Maleate, Hydrochlorothiazide) supplied by GNH India

Linatil Comp

Active Ingredient:
Enalapril Maleate, Hydrochlorothiazide
Origin:
EU

Linatil Comp (Enalapril Maleate, Hydrochlorothiazide)

Enalapril maleate, the active ingredient in Linatil Comp, is an ACE inhibitor presented as a combined oral tablet for oral use. It is used to treat hypertension, often in combination with hydrochlorothiazide, and is prescribed for adult patients requiring blood pressure control.

GNH India supplies Linatil Comp as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable sourcing for regulated markets. Its distribution network ensures timely delivery across Europe, Asia, Africa and the Americas.

Manufacturer / TM Owner

Hexal A/S

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Indications & Clinical Uses

Linatil Comp, containing enalapril and hydrochlorothiazide, is employed in the management of hypertension, a condition of chronically elevated arterial pressure.

  • Essential hypertension: lowers systolic and diastolic blood pressure, reducing cardiovascular risk.
  • Hypertension with fluid retention: combines ACE inhibition and diuretic action to improve blood pressure and volume control.
  • Patients needing combination therapy: provides both agents in a single tablet, simplifying dosing and adherence.

How It Works

  • Enalapril maleate blocks the angiotensin‑converting enzyme, decreasing formation of angiotensin II and thereby reducing vasoconstriction and aldosterone secretion. Hydrochlorothiazide acts on the distal convoluted tubule to inhibit sodium‑chloride reabsorption, promoting diuresis, lowering plasma volume and peripheral resistance. The combined actions result in sustained blood‑pressure reduction.

Side Effects

Linatil Comp may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Cough: dry, persistent throat irritation.
  • Dizziness or light‑headedness, especially after the first dose.
  • Headache.
  • Fatigue.
  • Increased urinary frequency.
  • Electrolyte disturbances (e.g., low potassium).

Serious or Rare Side Effects

  • Angioedema: swelling of face, lips, tongue or airway.
  • Severe hypotension: marked drop in blood pressure.
  • Acute renal failure or worsening kidney function.
  • Hyperkalemia: elevated blood potassium levels.
  • Pancreatitis.
  • Blood dyscrasias such as agranulocytosis.

Precautions & Warnings

Before prescribing Linatil Comp, clinicians should consider several safety precautions to minimize risk.

  • Blood pressure monitoring: check regularly to avoid hypotension.
  • Renal function assessment: evaluate serum creatinine and eGFR before and during therapy.
  • Electrolyte surveillance: monitor potassium and sodium levels.
  • Pregnancy contraindication: avoid use in pregnancy due to fetal risk.
  • Elderly patients: start at lower dose and monitor for orthostatic symptoms.
  • Store at room temperature: keep in original packaging, protect from moisture and heat.

Avoid Interactions

Linatil Comp can interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Aliskiren: combined use with ACE inhibitors may increase risk of renal impairment.
  • Potassium‑sparing diuretics or supplements: may cause dangerous hyperkalaemia.
  • NSAIDs (e.g., ibuprofen, naproxen): can reduce antihypertensive effect and impair kidney function.

Moderate Interactions (Monitor Closely)

  • Lithium: ACE inhibitors may increase lithium levels, risking toxicity.
  • Antidiabetic agents (e.g., insulin, sulfonylureas): may enhance hypoglycaemic effect.
  • Other antihypertensives (e.g., beta‑blockers, calcium channel blockers): may cause additive blood pressure lowering.

Frequently Asked Questions

Linatil Comp is a prescription tablet that combines enalapril maleate, an ACE inhibitor, with hydrochlorothiazide, a thiazide diuretic. It is indicated for the treatment of hypertension, helping to lower elevated blood pressure and reduce the risk of cardiovascular complications in adult patients.

Enalapril maleate blocks the angiotensin‑converting enzyme, which reduces the production of angiotensin II, a potent vasoconstrictor. This leads to relaxation of blood vessels, decreased aldosterone release, and ultimately lower blood pressure. The effect is complemented by hydrochlorothiazide’s diuretic action.

The dosage of Linatil Comp is individualized by the prescribing clinician based on the patient’s blood‑pressure profile, renal function, and response to therapy. The prescriber determines the appropriate strength and dosing schedule; patients should follow the exact instructions provided on the prescription label.

Linatil Comp is classified as pregnancy category D, indicating evidence of risk to the fetus. It should be avoided during pregnancy, especially in the second and third trimesters. Safety during breastfeeding has not been established, so the medication is generally not recommended for nursing mothers.

To request Linatil Comp, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide. After submission, the sales team will verify trade or institutional credentials and respond with pricing, availability, shipping details and any required import documentation.

Linatil Comp offers the convenience of a fixed‑dose combination of an ACE inhibitor and a thiazide diuretic, which can improve adherence compared with taking two separate tablets. Compared with monotherapy, the combination provides synergistic blood‑pressure reduction, but clinicians must consider individual tolerability and potential drug interactions.

Linatil Comp tablets should be stored at room temperature, below 25 °C, in their original blister pack or container. Protect them from excess moisture, direct sunlight and heat. Do not store in a refrigerator or freezer, and keep out of reach of children.

Linatil Comp is taken orally, usually once daily or as directed by the prescriber. The tablet should be swallowed whole with a full glass of water, and can be taken with or without food unless the prescribing information advises otherwise.

Serious risks include angioedema (swelling of the face, lips, tongue or airway), severe hypotension, acute kidney injury, and hyperkalaemia. Patients should seek immediate medical attention if they experience swelling, difficulty breathing, sudden dizziness, or a marked drop in blood pressure.

Linatil Comp is contraindicated in patients with a known hypersensitivity to enalapril, hydrochlorothiazide, or any component of the formulation. It should also be avoided in individuals with hereditary angioedema, severe renal impairment, or during pregnancy. Clinicians must evaluate each patient’s medical history before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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