Product image of Lindilane (Paracetamol, Codeine Phosphate Hemihydrate) supplied by GNH India

Lindilane

Active Ingredient:
Paracetamol, Codeine Phosphate Hemihydrate
Origin:
EU

Lindilane (Paracetamol, Codeine Phosphate Hemihydrate)

Paracetamol and Codeine Phosphate Hemihydrate, the active ingredient in Lindilane, is a Analgesic presented as a combination tablet for oral use. It provides pain relief and reduces fever in adults and children when prescribed.

GNH India supplies Lindilane as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Laboratoires Grünenthal S.A.S.

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Indications & Clinical Uses

Lindilane, a combination analgesic, is used to manage pain and fever across several common conditions.

  • Pain: provides relief of moderate to severe acute pain.
  • Fever: reduces elevated body temperature.
  • Headache: alleviates tension‑type or migraine‑associated headache.

How It Works

  • Paracetamol acts centrally to inhibit cyclo‑oxygenase enzymes, decreasing prostaglandin synthesis and producing analgesic and antipyretic effects. Codeine phosphate hemihydrate is a prodrug metabolised by CYP2D6 to morphine, which activates μ‑opioid receptors in the central nervous system, enhancing analgesia.

Side Effects

Lindilane may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Nausea: mild to moderate upset stomach.
  • Constipation: reduced bowel movements.
  • Drowsiness: increased sleepiness.
  • Dizziness: sensation of light‑headedness.
  • Vomiting: occasional emesis.
  • Mild rash: transient skin irritation.

Serious or Rare Side Effects

  • Respiratory depression: slowed breathing, especially at high doses.
  • Severe allergic reaction: anaphylaxis with swelling, hives, or difficulty breathing.
  • Hepatic injury: potential liver damage with excessive paracetamol.
  • Dependence or addiction: risk of opioid‑related dependence.
  • Hypotension: low blood pressure episodes.
  • Seizures: rare convulsive events.

Precautions & Warnings

When prescribing Lindilane, consider the following safety measures.

  • Liver function assessment: evaluate hepatic status before initiating therapy.
  • Minimum effective dose: use the lowest dose that provides relief.
  • Respiratory caution: avoid in patients with compromised breathing.
  • Elderly monitoring: adjust use for older adults due to increased sensitivity.
  • CNS depressant avoidance: do not combine with other sedatives without supervision.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Lindilane can interact with several medicines; awareness helps prevent adverse outcomes.

Major Interactions (Avoid)

  • Other opioids: additive respiratory depression.
  • MAO inhibitors: risk of severe serotonin syndrome.
  • Central nervous system depressants (e.g., benzodiazepines, alcohol): enhanced sedation.
  • CYP2D6 inhibitors (e.g., fluoxetine, quinidine): reduced conversion of codeine to morphine.
  • Hepatotoxic drugs (e.g., isoniazid, high‑dose paracetamol): increased liver injury risk.

Moderate Interactions (Monitor Closely)

  • Antidepressants (SSRIs, SNRIs): possible increased serotonergic effects.
  • Antihistamines: may augment drowsiness.
  • Antihypertensives: potential additive hypotensive effect.
  • Diuretics: monitor electrolyte balance.
  • Antacids: may affect absorption of paracetamol.

Frequently Asked Questions

Lindilane is a prescription analgesic that combines paracetamol and codeine phosphate hemihydrate. It is indicated for the relief of moderate to severe pain, reduction of fever, and treatment of headache in adult and pediatric patients when a stronger opioid is not required.

Paracetamol reduces pain and fever by inhibiting central cyclo‑oxygenase enzymes, lowering prostaglandin production. Codeine phosphate hemihydrate is converted in the liver to morphine, which binds to μ‑opioid receptors in the brain and spinal cord, enhancing analgesic effects through opioid pathways.

The appropriate dose of Lindilane is determined by the prescribing clinician based on the patient’s age, weight, severity of symptoms, and medical history. Dosage instructions are provided on the prescription label and should be followed exactly as directed.

Safety of Lindilane in pregnancy or lactation depends on clinical judgment. Paracetamol is generally considered low risk, but codeine can cross the placenta and appear in breast milk. Healthcare providers should evaluate the risk‑benefit ratio before prescribing to pregnant or nursing individuals.

To request Lindilane, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with single‑ingredient paracetamol, Lindilane adds an opioid component, offering stronger pain relief for moderate to severe pain. Unlike stronger opioids such as morphine, it has a lower risk of respiratory depression but still requires careful monitoring for dependence and side effects.

Lindilane should be stored at room temperature, below 25 °C, in its original packaging. Protect the product from moisture, heat and direct sunlight to maintain potency and stability throughout its shelf life.

Lindilane is taken orally, usually with a full glass of water. It may be taken with or without food, but taking it with food can reduce gastrointestinal discomfort. Swallow tablets whole; do not crush or chew unless specifically instructed by a healthcare professional.

The most serious risks include respiratory depression, especially in opioid‑naïve patients or when combined with other depressants, severe allergic reactions (anaphylaxis), liver injury from excessive paracetamol, and the potential for dependence or abuse of the codeine component.

Lindilane is contraindicated in individuals with known hypersensitivity to paracetamol, codeine, or any excipients, those with severe respiratory insufficiency, acute or severe asthma, and patients taking monoamine oxidase inhibitors. Caution is also advised for patients with significant liver disease or a history of opioid dependence.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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