Product image of Linezolid Aurobindo (Linezolid) supplied by GNH India

Linezolid Aurobindo

Active Ingredient:
Linezolid
Origin:
EU

Linezolid Aurobindo (Linezolid)

Linezolid, the active ingredient in Linezolid Aurobindo, is an oxazolidinone presented as an intravenous formulation for parenteral use. It treats infections caused by susceptible Gram‑positive bacteria, including methicillin‑resistant Staphylococcus aureus (MRSA) and vancomycin‑resistant Enterococcus (VRE), in adult patients.

GNH India supplies Linezolid Aurobindo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Aurobindo Pharma România S.R.L.

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Indications & Clinical Uses

Linezolid is an oxazolidinone antibacterial used for serious Gram‑positive infections.

  • Complicated skin and soft‑tissue infections: provides effective coverage against MRSA and other resistant Gram‑positive pathogens.
  • Hospital‑acquired pneumonia, including ventilator‑associated pneumonia: offers bactericidal activity for resistant Gram‑positive organisms.
  • Infections caused by vancomycin‑resistant Enterococcus (VRE): serves as an alternative intravenous option for these difficult‑to‑treat infections.

How It Works

  • Linezolid inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, preventing formation of the initiation complex. This action blocks the translation step of protein production, leading to a bacteriostatic effect against susceptible Gram‑positive organisms, including MRSA and VRE.

Side Effects

Linezolid may cause a range of adverse reactions, from mild to serious.

Common Side Effects

  • Nausea: mild to moderate gastrointestinal upset.
  • Diarrhea: loose stools that may be self‑limiting.
  • Headache: transient cranial discomfort.
  • Metallic taste: altered taste sensation during therapy.

Serious or Rare Side Effects

  • Thrombocytopenia: significant drop in platelet count requiring monitoring.
  • Peripheral neuropathy: nerve damage that can be irreversible if untreated.
  • Serotonin syndrome: risk when combined with serotonergic agents.
  • Lactic acidosis: rare metabolic disturbance.
  • Optic neuropathy: visual disturbances that may be permanent.

Precautions & Warnings

Before initiating Linezolid therapy, consider the following safety measures.

  • Renal impairment: monitor renal function and adjust therapy as needed.
  • Hepatic impairment: use with caution and observe liver enzymes.
  • Concomitant serotonergic agents: avoid due to risk of serotonin syndrome.
  • Prolonged therapy (>14 days): perform regular complete blood count monitoring.
  • Pregnancy and lactation: safety not established; weigh benefits against risks.
  • Store at 2‑8°C: keep refrigerated, protect from light, do not freeze.

Avoid Interactions

Linezolid can interact with several drug classes; awareness of the interaction level is essential.

Major Interactions (Avoid)

  • Selective serotonin reuptake inhibitors (SSRIs): may precipitate serotonin syndrome.
  • Monoamine oxidase inhibitors (MAOIs): increase risk of serotonin toxicity.
  • Rifampicin: induces metabolism, reducing linezolid plasma concentrations.

Moderate Interactions (Monitor Closely)

  • Warfarin: may potentiate anticoagulant effect, requiring INR monitoring.
  • Phenytoin: may lower linezolid levels, affecting efficacy.
  • Erythromycin: can increase linezolid exposure, necessitating dose review.

Frequently Asked Questions

Linezolid Aurobindo is indicated for serious infections caused by susceptible Gram‑positive bacteria, including complicated skin and soft‑tissue infections, hospital‑acquired pneumonia (including ventilator‑associated pneumonia), and infections due to vancomycin‑resistant Enterococcus (VRE).

Linezolid inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, preventing the formation of the initiation complex required for translation. This blocks the production of essential proteins, resulting in a bacteriostatic effect against Gram‑positive organisms.

The dosage of Linezolid Aurobindo is determined by the prescribing clinician based on the infection type, severity, patient weight, renal and hepatic function, and local guidelines. The prescriber sets the appropriate regimen.

Safety of linezolid in pregnancy and lactation has not been fully established. It should be used only if the potential benefit justifies the potential risk to the fetus or infant, and the decision should be made by the treating physician.

To order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Linezolid belongs to the oxazolidinone class and offers oral and intravenous options with activity against MRSA and VRE, which many beta‑lactams cannot treat. Compared with vancomycin, linezolid provides similar efficacy but with a different safety profile, lacking nephrotoxicity but carrying risks of hematologic and neurologic effects.

Linezolid Aurobindo should be stored at 2‑8 °C in a refrigerator, protected from light, and should not be frozen or shaken. Keep the product in its original packaging until use to maintain stability.

The product is supplied for intravenous administration. It is reconstituted with the appropriate diluent according to the manufacturer’s instructions and infused over the recommended period under aseptic conditions.

Serious risks include thrombocytopenia, peripheral neuropathy, optic neuropathy, serotonin syndrome when combined with serotonergic drugs, and rare metabolic disturbances such as lactic acidosis. Regular monitoring of blood counts and neurological status is advised during prolonged treatment.

Patients with known hypersensitivity to linezolid or any component of the formulation should avoid it. Caution is also advised for individuals taking serotonergic agents, those with uncontrolled hypertension, or patients with pre‑existing severe bone marrow suppression.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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