Product image of Linisan (Citalopram Hydrobromide) supplied by GNH India

Linisan

Active Ingredient:
Citalopram Hydrobromide
Origin:
EU

Linisan (Citalopram Hydrobromide)

Citalopram hydrobromide, the active ingredient in Linisan, is a selective serotonin reuptake inhibitor presented as an oral tablet for oral use. It is prescribed to treat major depressive disorder in adult patients.

GNH India supplies Linisan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards, provides batch‑tested products, and supports regulatory compliance for importers across Europe, Asia, Africa and the Americas. Customers benefit from reliable logistics, transparent documentation, and responsive technical assistance throughout the supply chain.

Manufacturer / TM Owner

Gedeon Richter România S.A.

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Indications & Clinical Uses

Citalopram hydrobromide is an SSRI that modulates serotonergic pathways in depressive and related mood disorders.

  • Major depressive disorder: alleviates depressive symptoms and improves mood in adult patients.
  • Panic disorder: reduces frequency and intensity of panic attacks.
  • Obsessive‑compulsive disorder: diminishes obsessive thoughts and compulsive behaviors.

How It Works

  • Citalopram hydrobromide selectively inhibits the serotonin transporter (SERT) on presynaptic neurons, blocking reuptake of serotonin (5‑HT) from the synaptic cleft. This increases extracellular serotonin concentrations, enhancing serotonergic neurotransmission throughout central nervous system pathways that regulate mood, anxiety and cognition. The heightened serotonergic activity underlies its antidepressant and anxiolytic effects. The drug does not significantly affect other neurotransmitter systems, contributing to its relatively specific pharmacological profile.

Side Effects

Citalopram hydrobromide may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea: mild gastrointestinal upset.
  • Headache: transient cranial discomfort.
  • Dry mouth: reduced salivation.
  • Insomnia: difficulty falling or staying asleep.

Serious or Rare Side Effects

  • Serotonin syndrome: agitation, hyperthermia, muscle rigidity.
  • QT interval prolongation: risk of cardiac arrhythmia.
  • Severe allergic reaction: rash, swelling, anaphylaxis.

Precautions & Warnings

When prescribing citalopram hydrobromide, clinicians should consider several safety precautions to minimize risk.

  • Cardiac assessment: evaluate baseline ECG and QT interval, especially in patients with cardiac disease.
  • Electrolyte monitoring: check serum sodium and potassium levels to prevent hyponatremia.
  • Serotonin syndrome vigilance: avoid concurrent use of other serotonergic agents.
  • Discontinuation strategy: taper the dose gradually to reduce withdrawal symptoms.
  • Elderly caution: start at lower dose and monitor for increased sensitivity.
  • Store at ambient temperature: keep tablets below 25 °C in the original container, protected from moisture and light.

Avoid Interactions

Citalopram hydrobromide interacts with several medicines; awareness of major and moderate interactions helps ensure safe co‑administration.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors (MAOIs): risk of severe serotonin syndrome.
  • Pimozide: can cause cardiac arrhythmias due to QT prolongation.
  • Linezolid or tramadol: additive serotonergic effects increasing serotonin syndrome risk.

Moderate Interactions (Monitor Closely)

  • NSAIDs and anticoagulants: heightened bleeding tendency.
  • CYP2C19 inhibitors (e.g., omeprazole): may increase citalopram plasma levels.
  • Alcohol: can enhance central nervous system depression.
  • Antihistamines: may increase sedation.

Frequently Asked Questions

Linisan contains citalopram hydrobromide, an SSRI indicated primarily for the treatment of major depressive disorder in adult patients. It may also be prescribed for certain anxiety‑related conditions such as panic disorder and obsessive‑compulsive disorder, depending on local regulatory approvals and clinical judgment.

Citalopram blocks the serotonin transporter on presynaptic neurons, preventing reuptake of serotonin from the synaptic cleft. This raises extracellular serotonin levels, enhancing serotonergic signaling in brain circuits that regulate mood, anxiety, and cognition, which contributes to its antidepressant and anxiolytic actions.

The appropriate dose of Linisan is determined by the prescribing clinician based on the individual’s medical condition, age, response to therapy, and any concomitant medications. Dosage adjustments may be required for special populations, and patients should follow the prescriber’s instructions without self‑adjusting the dose.

Safety data for citalopram during pregnancy and lactation are limited. Healthcare providers should weigh potential benefits against possible risks to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss treatment options with their physician before initiating or continuing Linisan.

To request Linisan, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Linisan belongs to the SSRI class, which generally offers a favorable side‑effect profile compared with older tricyclic antidepressants and monoamine oxidase inhibitors. Compared with other SSRIs, citalopram has a relatively selective effect on serotonin reuptake and a lower affinity for other receptors, though individual response and tolerability can vary.

Linisan tablets should be stored at ambient temperature, preferably below 25 °C, in the original packaging to protect them from moisture and light. Keep the product out of reach of children and do not use after the expiration date printed on the label.

Linisan is taken orally, usually once daily with or without food, as directed by the prescriber. The tablet should be swallowed whole with a glass of water and not crushed or chewed unless specifically instructed by a healthcare professional.

The most serious risks include serotonin syndrome—a potentially life‑threatening condition characterized by agitation, hyperthermia, and muscle rigidity—and cardiac arrhythmias due to QT interval prolongation. Patients should also be monitored for emerging suicidal thoughts, especially during the early weeks of therapy.

Linisan is contraindicated in individuals who have a known hypersensitivity to citalopram or any component of the formulation, and in patients currently taking monoamine oxidase inhibitors. Caution is advised for those with a history of cardiac conduction abnormalities, uncontrolled electrolyte disturbances, or severe hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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