Product image of Linola (Urea) supplied by GNH India

Linola

Active Ingredient:
Urea
Origin:
EU

Linola (Urea)

Urea, the active ingredient in Linola, is a keratinolytic agent presented as a topical formulation for skin application. It softens hyperkeratotic skin, promotes desquamation, and is used to manage dry skin conditions, ichthyosis, hyperkeratosis, and psoriasis. It is available over the counter in the European market and is formulated to be applied directly to affected areas, helping to restore skin hydration and reduce scaling.

GNH India supplies Linola as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, providing reliable sourcing, quality assurance and regulatory compliance for global healthcare providers.

Manufacturer / TM Owner

Dr. August Wolff Gmbh & Co. Kg Arzneimittel

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Indications & Clinical Uses

Linola (urea) acts as a keratinolytic and hygroscopic agent to treat disorders characterized by dry, thickened skin.

  • Dry skin: hydrates and softens the stratum corneum, reducing roughness and scaling.
  • Ichthyosis: improves skin texture by promoting desquamation and moisture retention.
  • Hyperkeratosis: softens thickened plaques and facilitates their removal.
  • Psoriasis: helps to reduce scaling and improve lesion pliability.

How It Works

  • Urea exerts a keratinolytic effect by disrupting hydrogen bonds within keratin fibers, leading to softening of hyperkeratotic tissue. Its hygroscopic properties draw water into the stratum corneum, increasing skin hydration and promoting natural desquamation. The combined actions result in smoother, more supple skin and facilitate the removal of excess keratin.

Side Effects

Topical urea is generally well tolerated, but some users may experience local reactions.

Common Side Effects

  • Mild stinging or burning sensation at the application site.
  • Transient redness or erythema.
  • Slight itching or pruritus.
  • Dryness or flaking after initial use.

Serious or Rare Side Effects

  • Allergic contact dermatitis presenting with swelling, vesicles, or intense itching.
  • Severe skin irritation leading to ulceration.
  • Systemic absorption causing metabolic disturbances (extremely rare).

Precautions & Warnings

Before using Linola, consider the following precautions.

  • Allergy assessment: avoid if known hypersensitivity to urea or formulation excipients.
  • Open wounds: do not apply to broken skin or extensive erosions.
  • Concurrent keratolytics: use with caution when combined with other strong exfoliants.
  • Pediatric use: consult a healthcare professional before applying to children.
  • Pregnancy and lactation: safety not established; discuss with a physician.
  • Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Topical urea may interact with other skin products, affecting efficacy or irritation risk.

Major Interactions (Avoid)

  • Strong keratolytic agents (e.g., high‑strength salicylic acid): may cause excessive irritation.
  • Occlusive dressings immediately after application: can increase absorption and irritation.

Moderate Interactions (Monitor Closely)

  • Other moisturizers containing alcohol: may enhance stinging sensation.
  • Topical corticosteroids: may alter skin barrier, requiring monitoring for irritation.

Frequently Asked Questions

Linola contains urea and is used to manage dry skin, ichthyosis, hyperkeratosis and psoriasis. It works by softening thickened skin and improving hydration, helping to reduce scaling and roughness in these dermatologic conditions.

Urea acts as a keratinolytic and hygroscopic agent. It disrupts hydrogen bonds in keratin, softening hyperkeratotic tissue, while its ability to attract water increases skin moisture, promoting natural desquamation and smoother skin.

The appropriate amount and frequency of Linola are determined by the prescribing healthcare professional based on the severity of the skin condition and the patient’s individual needs. No fixed dosing regimen is provided here.

Safety data for urea‑containing topical products in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss use with their physician before applying Linola.

To place an order, submit an enquiry on the Linola product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with stronger keratolytics such as high‑strength salicylic acid, Linola’s urea concentration offers a milder, more tolerable option for long‑term use, especially on sensitive or extensive areas. It provides both moisturizing and exfoliating benefits, whereas some alternatives focus mainly on keratolysis.

Linola should be stored at ambient temperature, away from direct sunlight and moisture. Keep the product in its original packaging to maintain stability and protect it from contamination.

Linola is applied topically to clean, dry skin. A thin layer is spread over the affected area, gently massaged until absorbed. Frequency of application is set by the prescriber, typically once or twice daily.

The most serious risks include allergic contact dermatitis, which may present with swelling, vesicles or intense itching, and severe local irritation that could lead to ulceration. If any of these occur, discontinue use and seek medical attention promptly.

Linola should not be used by individuals with a known hypersensitivity to urea or any excipients in the formulation, on open wounds or extensive skin erosions, and it should be avoided in patients where a healthcare professional advises against its use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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