Product image of Linola (Urea) supplied by GNH India

Linola

Active Ingredient:
Urea
Origin:
EU

Linola (Urea)

Urea, the active ingredient in Linola, is a keratolytic presented as a topical formulation for skin application. It helps to soften and hydrate dry, hyperkeratotic skin and is used in conditions such as dry skin, ichthyosis, hyperkeratosis and eczema in adults and children as appropriate.

GNH India supplies Linola as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation for export to multiple regions across global markets.

Manufacturer / TM Owner

Dr. August Wolff Gmbh & Co. Kg Arzneimittel

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Indications & Clinical Uses

Linola (urea) is a keratolytic used to manage disorders characterized by dry or hyperkeratotic skin.

  • Dry skin: improves skin hydration and reduces scaling.
  • Ichthyosis: helps normalize the skin barrier and decrease roughness.
  • Hyperkeratosis: facilitates desquamation of thickened skin layers.
  • Eczema: alleviates dryness and supports barrier repair.

How It Works

  • Urea acts as a keratolytic by disrupting hydrogen bonds within keratin, which increases water binding capacity of the stratum corneum. This leads to enhanced skin hydration, softening of hyperkeratotic plaques, and promotion of natural desquamation, thereby improving the texture and flexibility of affected skin.

Side Effects

Topical urea is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Mild skin irritation: transient redness or tingling at the application site.
  • Itching: occasional pruritus during early use.
  • Dryness or peeling: temporary flaking as the skin adjusts.

Serious or Rare Side Effects

  • Allergic contact dermatitis: swelling, blistering, or severe rash.
  • Severe skin irritation: persistent burning or pain requiring medical attention.
  • Secondary infection: signs of infection such as pus or increased warmth.

Precautions & Warnings

Before using Linola, consider the following safety measures.

  • Avoid application on broken skin: may increase irritation.
  • Do not use with other strong keratolytics without medical advice: risk of excessive irritation.
  • Limit exposure to eyes: avoid contact and rinse thoroughly if accidental.
  • Discontinue if severe irritation occurs: seek medical advice promptly.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Topical urea may interact with certain skin products; monitor accordingly.

Major Interactions (Avoid)

  • Concurrent use with strong topical steroids: may increase skin thinning.
  • Combination with other keratolytics (e.g., salicylic acid): risk of excessive irritation.
  • Use with occlusive dressings: may enhance systemic absorption.

Moderate Interactions (Monitor Closely)

  • Use with moisturizers: generally safe but watch for additive irritation.
  • Use with topical antibiotics: monitor for allergic reactions.
  • Use with cosmetic products containing fragrances: may increase sensitization risk.

Frequently Asked Questions

Linola, containing urea, is indicated for the topical management of dry skin, ichthyosis, hyperkeratosis and eczema. It helps to hydrate the skin, reduce scaling and promote the shedding of thickened skin layers, improving overall skin texture.

Urea acts as a keratolytic by breaking hydrogen bonds in keratin, which increases the water‑binding capacity of the stratum corneum. This results in better skin hydration, softening of hyperkeratotic plaques, and enhanced natural desquamation.

The dosage of Linola is determined by the prescribing healthcare professional based on the severity of the skin condition, the area to be treated and patient factors. The prescriber will provide specific instructions on the amount and frequency of application.

Safety data for topical urea in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should consult their healthcare provider before using Linola to weigh potential benefits against any unknown risks.

To order Linola, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request trade or institutional credentials before providing pricing, availability, shipping details and any necessary import documentation.

Compared with alternatives such as salicylic acid or alpha‑hydroxy acids, urea offers both keratolytic and humectant properties, providing hydration while softening thickened skin. It is generally milder and less irritating, making it suitable for sensitive or extensive skin areas.

Linola should be stored at room temperature, below 25 °C, in its original packaging. Keep the product away from moisture, direct sunlight and extreme temperatures to maintain its stability and effectiveness.

Linola is applied topically to the affected skin area. Clean and gently dry the skin, then spread a thin layer of the product as directed by the prescriber, usually once or twice daily, and allow it to absorb before covering with clothing.

The most serious risks include allergic contact dermatitis, severe skin irritation, and secondary infection if the skin barrier is compromised. Users should discontinue use and seek medical attention if they experience swelling, blistering, intense burning or signs of infection.

Linola should be avoided in individuals with known hypersensitivity to urea or any excipients in the formulation, on open wounds or heavily broken skin, and in patients where a healthcare professional advises against its use due to specific medical conditions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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