Product image of Linola (Urea) supplied by GNH India

Linola

Active Ingredient:
Urea
Origin:
EU

Linola (Urea)

Urea, the active ingredient in Linola, is a keratolytic presented as a topical preparation for skin application. It helps hydrate the skin and promotes the shedding of excess keratin, making it useful for dry, scaly or hyperkeratotic conditions in adults and children.
GNH India supplies Linola as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Dr. August Wolff Gmbh & Co. Kg Arzneimittel

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Indications & Clinical Uses

  • Linola (Urea) is applied topically to manage disorders characterized by excessive keratin buildup and skin dryness.
  • Dry skin: restores moisture and softens scaling.
  • Ichthyosis: reduces hyperkeratinization and improves skin texture.
  • Psoriasis: alleviates plaque scaling and promotes desquamation.
  • Hyperkeratosis: softens thickened skin and facilitates shedding.

How It Works

  • Urea acts as a hygroscopic agent that draws water into the stratum corneum, increasing skin hydration. It disrupts hydrogen bonds within keratin fibers, weakening the protein matrix and promoting keratolysis, which leads to softening and desquamation of hyperkeratotic skin layers.

Side Effects

Common Side Effects

  • Mild skin irritation or itching at the application site.
  • Transient burning or stinging sensation.
  • Redness or erythema.
  • Dryness or peeling of treated skin.

Serious or Rare Side Effects

  • Allergic contact dermatitis with swelling and rash.
  • Severe skin ulceration or bullous reactions.
  • Systemic toxicity (rare) with signs such as nausea or headache.

Precautions & Warnings

Before using Linola, consider the following precautions:

  • Pregnancy: safety not established; avoid unless benefits outweigh risks.
  • Breastfeeding: unknown; consult a healthcare professional.
  • Skin integrity: do not apply to broken, infected, or inflamed skin.
  • Concurrent keratolytics: monitor for increased irritation.
  • Allergy: discontinue if hypersensitivity develops.
  • Store at ambient temperature: keep container tightly closed, protect from moisture and direct sunlight.

Avoid Interactions

Linola may interact with other topical agents.

Major Interactions (Avoid)

  • Use with strong topical steroids may increase irritation.
  • Combination with other keratolytic agents (e.g., salicylic acid) can cause excessive peeling.
  • Large‑area application with systemic diuretics may increase rare systemic absorption.

Moderate Interactions (Monitor Closely)

  • Co‑application with moisturizers may enhance efficacy.
  • Use under occlusive dressings may increase absorption.
  • Concurrent topical antibiotics may mask infection signs.

Frequently Asked Questions

Linola is a topical formulation containing urea that is used to treat dry skin, ichthyosis, psoriasis and other hyperkeratotic skin conditions. By hydrating the stratum corneum and promoting keratolysis, it helps soften scaling, improve skin texture and reduce discomfort associated with these disorders.

Urea acts as a hygroscopic molecule that attracts water into the outer skin layer, increasing hydration. It also disrupts hydrogen bonds within keratin proteins, weakening the skin’s protective barrier and facilitating the shedding of excess keratin. This dual action softens thickened skin and promotes natural desquamation.

The amount of Linola to apply is determined by the prescribing healthcare professional based on the severity of the condition, the area of skin involved and patient age. Typically, a thin layer is spread over the affected area once or twice daily, but exact instructions should follow the prescriber’s order.

Safety data for Linola in pregnancy and lactation are limited. The product’s pregnancy category is unknown, so it should only be used if the potential benefit justifies any possible risk to the fetus. Breastfeeding mothers should consult their physician before using Linola.

To order Linola, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Linola’s urea base offers both moisturizing and keratolytic effects, whereas agents such as salicylic acid primarily provide keratolysis with less hydration. Urea is generally better tolerated on sensitive skin and can be combined with moisturizers, while stronger acids may cause more irritation but act more rapidly on thick plaques.

Linola should be stored at ambient temperature, away from direct sunlight and moisture. Keep the container tightly closed when not in use. Do not freeze the product, and ensure it is kept out of reach of children.

Linola is applied topically to clean, dry skin. A thin layer is spread over the affected area and gently massaged until absorbed. Frequency of application—usually once or twice daily—depends on the prescriber’s recommendation and the severity of the skin condition.

Serious risks, though rare, include allergic contact dermatitis, severe skin ulceration or bullous reactions, and systemic toxicity if large amounts are absorbed. Patients should stop using the product and seek medical attention if they notice extensive swelling, blistering, or systemic symptoms such as nausea or headache.

Linola should not be used on broken, infected or inflamed skin, and individuals with a known hypersensitivity to urea or any excipients in the formulation should avoid it. Patients with severe renal impairment should consult a physician before use, as systemic absorption may be increased.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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