Linoladiol-H N (Estradiol Hemihydrate, Prednisolone Sesquihydrate)

Estradiol hemihydrate binds to estrogen receptors in skin cells, stimulating gene expression that promotes epithelial growth, collagen production, and tissue repair. This hormonal action helps restore skin thickness and integrity, especially in hormone‑deficient states.

The dosage of Linoladiol-H N is individualized. A qualified prescriber sets the amount, frequency, and duration based on the patient’s condition, treatment area, and response. Patients should follow the healthcare professional’s instructions precisely.

Safety in pregnancy and lactation has not been fully established for this combination. Because estradiol and prednisolone can cross the placenta and enter breast milk, the product should be used only if the potential benefit justifies the potential risk, and only under medical supervision.

To order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain needs) and required import documentation.

Linoladiol-H N combines a specific estrogen (estradiol hemihydrate) with a potent glucocorticoid (prednisolone sesquihydrate). Compared with products that use weaker steroids or different estrogen forms, it may offer stronger anti‑inflammatory action and more pronounced estrogenic skin benefits, but it also requires careful monitoring for systemic effects.

Store the product at ambient temperature below 25 °C, in its original container, protected from moisture and direct sunlight. Keep out of reach of children and avoid freezing the preparation.

Linoladiol-H N is applied topically to the affected skin area. The prescribed amount is spread thinly and gently massaged until fully absorbed. Hands should be washed before and after application, and the treated area should be clean and dry.

Serious risks include severe allergic reactions (anaphylaxis), significant skin atrophy or striae with prolonged use, systemic hormonal effects such as thromboembolic events, and systemic glucocorticoid effects like elevated blood glucose or hypertension. Immediate medical attention is required if any of these occur.

Patients with known hypersensitivity to estradiol, prednisolone, or any excipients in the formulation should avoid it. It is also contraindicated on infected, broken, or ulcerated skin, and in individuals with uncontrolled diabetes, hypertension, or a history of thromboembolic disorders unless specifically directed by a physician.