Product image of Liofora Diario (Drospirenone, Ethinylestradiol | Lactose Monohydrate) supplied by GNH India

Liofora Diario

Active Ingredient:
Drospirenone, Ethinylestradiol | Lactose Monohydrate
Origin:
EU

Liofora Diario (Drospirenone, Ethinylestradiol | Lactose Monohydrate)

Drospirenone/Ethinylestradiol, the active ingredient in Liofora Diario, is a combined oral contraceptive presented as an oral tablet for systemic use. It is prescribed to prevent pregnancy and to help regulate menstrual cycles in women of reproductive age. The formulation combines a progestogenic steroid with an estrogenic component to provide reliable cycle control and contraceptive efficacy.

GNH India supplies Liofora Diario as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Bayer Hispania Sl

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Indications & Clinical Uses

Liofora Diario, a combined oral contraceptive, is used in the management of reproductive health conditions.

  • Contraception: prevents pregnancy by inhibiting ovulation and altering cervical mucus.
  • Menstrual cycle regulation: provides more predictable bleeding patterns and reduces dysmenorrhea.
  • Acne treatment: improves moderate acne associated with androgen excess in women.
  • Premenstrual syndrome relief: lessens symptoms such as mood swings and breast tenderness.
  • Polycystic ovary syndrome symptom management: helps control menstrual irregularities and hyperandrogenic signs.

How It Works

  • Drospirenone/Ethinylestradiol exerts its contraceptive effect by binding to progesterone receptors, where drospirenone acts as a progestin with anti‑mineralocorticoid and anti‑androgenic activity, while ethinylestradiol activates estrogen receptors. The combination suppresses the mid‑cycle surge of luteinising hormone and follicle‑stimulating hormone, preventing ovulation. It also induces changes in cervical mucus that impede sperm penetration and alters the endometrial lining, reducing the likelihood of implantation.

Side Effects

Liofora Diario may be associated with a range of adverse reactions, which are generally classified by frequency and severity.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Headache: tension‑type or migraine‑like pain.
  • Breast tenderness: swelling or soreness of the breasts.
  • Spotting or breakthrough bleeding: irregular light bleeding between periods.

Serious or Rare Side Effects

  • Venous thromboembolism: deep‑vein thrombosis or pulmonary embolism.
  • Stroke or transient ischemic attack: neurological events due to clot formation.
  • Myocardial infarction: heart attack resulting from coronary artery blockage.
  • Severe allergic reaction: anaphylaxis, angioedema, or skin rash.

Precautions & Warnings

Before prescribing Liofora Diario, clinicians should evaluate several safety considerations to minimise risk.

  • Assess cardiovascular risk: review history of thromboembolic disorders, hypertension, or smoking.
  • Evaluate hepatic function: avoid use in severe liver disease.
  • Counsel about missed tablets: advise prompt action and backup contraception.
  • Review concomitant medications: consider potential drug interactions that may reduce efficacy.
  • Avoid use during pregnancy: discontinue if pregnancy is confirmed.
  • Store at room temperature: keep in the original packaging, protect from moisture and light.

Avoid Interactions

Liofora Diario can interact with other medicines, altering its effectiveness or increasing adverse effects.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers (e.g., rifampin, carbamazepine): markedly reduce contraceptive efficacy.
  • Certain antiretrovirals (e.g., protease inhibitors): may lower hormone levels.
  • St John’s wort: herbal supplement that accelerates hormone metabolism.

Moderate Interactions (Monitor Closely)

  • Antihypertensives (e.g., ACE inhibitors): drospirenone may increase serum potassium.
  • Potassium‑sparing diuretics: risk of hyperkalaemia when combined.
  • Selective serotonin reuptake inhibitors: may affect mood or bleeding patterns.

Frequently Asked Questions

Liofora Diario is a combined oral contraceptive indicated for preventing pregnancy and for regulating menstrual cycles in women of reproductive age. It may also be prescribed to manage moderate acne, alleviate premenstrual syndrome symptoms, and address menstrual irregularities associated with polycystic ovary syndrome.

The drospirenone component acts as a progestin with anti‑mineralocorticoid and anti‑androgenic properties, while ethinylestradiol provides estrogenic activity. Together they suppress the mid‑cycle surge of luteinising hormone and follicle‑stimulating hormone, preventing ovulation, and they modify cervical mucus and the endometrial lining to reduce the chance of fertilisation and implantation.

The dosing regimen for Liofora Diario is determined by the prescribing healthcare professional. Typically, the product is taken as one tablet daily at the same time each day, but the exact schedule, duration, and any special instructions are set by the prescriber based on the individual’s clinical needs.

Liofora Diario is contraindicated during pregnancy because it is intended to prevent conception, not to support an existing pregnancy. Women who become pregnant should discontinue use immediately. Safety data for breastfeeding are limited; the decision to use the product while nursing should be made by a healthcare provider after weighing potential risks and benefits.

To order Liofora Diario, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams across international markets. After the initial request, the sales team will verify trade or institutional credentials, then provide pricing, availability, shipping details and any necessary import documentation.

Liofora Diario contains drospirenone, a progestin with anti‑mineralocorticoid and anti‑androgenic activity, which may offer benefits such as reduced water retention and improved acne control compared with some older progestins. Efficacy in preventing pregnancy is comparable to other combined oral contraceptives, but the side‑effect profile and individual tolerability can differ, so clinicians choose the formulation that best matches a patient’s health status and preferences.

Liofora Diario tablets should be stored at room temperature, below 25 °C, in the original blister pack or container. Protect the product from excess moisture, heat and direct sunlight. Keep the medication out of reach of children and do not use it after the expiry date printed on the packaging.

Liofora Diario is taken orally, usually once daily at the same time each day. The tablet is swallowed whole with water and can be taken with or without food. If a dose is missed, follow the product’s missed‑dose instructions or consult a healthcare professional for guidance on backup contraception.

The most serious risks include venous thromboembolism (deep‑vein thrombosis or pulmonary embolism), arterial thrombosis such as stroke or myocardial infarction, and severe allergic reactions. These events are rare but can be life‑threatening, especially in women with pre‑existing cardiovascular risk factors, smoking habits, or certain genetic clotting disorders.

Liofora Diario should be avoided by women who are pregnant, have a known or suspected breast cancer, have a history of thromboembolic disorders, uncontrolled hypertension, severe liver disease, or who are smokers over the age of 35. It is also contraindicated in individuals with known hypersensitivity to drospirenone, ethinylestradiol, lactose, or any other excipients in the tablet.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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