Product image of Liofora (Drospirenone, Ethinylestradiol) supplied by GNH India

Liofora

Active Ingredient:
Drospirenone, Ethinylestradiol
Origin:
EU

Liofora (Drospirenone, Ethinylestradiol)

Drospirenone, the active ingredient in Liofora, is a combined oral contraceptive presented as a Drospirenone 3 mg / Ethinylestradiol 20 µg tablet for oral use. It is indicated for the prevention of pregnancy in women of reproductive age by inhibiting ovulation and altering cervical mucus.

GNH India supplies Liofora as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality and regulatory compliance across markets.

Manufacturer / TM Owner

Bayer B.V.

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Indications & Clinical Uses

  • Liofora, a combined oral contraceptive, is used within the hormonal contraceptive pathway to prevent unintended pregnancy.
  • Prevention of pregnancy: provides reliable contraceptive protection when taken as directed.

How It Works

  • Drospirenone acts as a synthetic progestogen with anti‑mineralocorticoid and anti‑androgenic activity, while ethinylestradiol is a synthetic estrogen. Together they suppress the mid‑cycle surge of luteinising hormone (LH) and follicle‑stimulating hormone (FSH), preventing ovulation. The combination also thickens cervical mucus and induces endometrial changes that reduce the likelihood of fertilisation and implantation.

Side Effects

Liofora may cause a range of adverse reactions. Patients should be aware of both common and serious possibilities.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Breast tenderness: discomfort or swelling of the breasts.
  • Headache: occasional mild to moderate pain.
  • Spotting or breakthrough bleeding: irregular vaginal bleeding.
  • Weight gain: modest increase in body weight.
  • Mood changes: irritability or mood swings.

Serious or Rare Side Effects

  • Venous thromboembolism: deep‑vein thrombosis or pulmonary embolism.
  • Arterial thrombosis: stroke or myocardial infarction.
  • Severe hypertension: significant increase in blood pressure.
  • Liver disorders: cholestatic jaundice or hepatic dysfunction.
  • Gallbladder disease: cholelithiasis or cholecystitis.
  • Severe allergic reaction: anaphylaxis or angioedema.

Precautions & Warnings

  • Before prescribing Liofora, clinicians should evaluate several safety considerations.
  • Assess cardiovascular risk: review history of thrombosis, smoking status, and age over 35.
  • Review hepatic function: avoid in severe liver disease.
  • Monitor blood pressure: discontinue if hypertension develops.
  • Consider smoking status: avoid in women >35 who smoke.
  • Store at ambient temperature: keep below 25 °C, retain original packaging, and protect from moisture.

Avoid Interactions

Liofora can interact with other medicines, affecting its efficacy or safety.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers (e.g., rifampicin, carbamazepine): may reduce contraceptive effectiveness.
  • Anticoagulants: may increase bleeding risk.

Moderate Interactions (Monitor Closely)

  • Other hormonal therapies: may increase overall estrogen exposure.
  • Antihypertensives: may alter blood pressure control.
  • Certain antibiotics (e.g., azithromycin): potential uncertain effect on hormone levels.

Frequently Asked Questions

Liofora is a combined oral contraceptive containing drospirenone and ethinylestradiol. It is prescribed to prevent unintended pregnancy in women of reproductive age. The tablet works when taken daily as directed, providing reliable contraceptive protection through inhibition of ovulation and changes in cervical mucus.

Drospirenone is a synthetic progestogen that binds to progesterone receptors, exerting anti‑mineralocorticoid and anti‑androgenic activity. In combination with ethinylestradiol, it suppresses the mid‑cycle surge of luteinising hormone (LH) and follicle‑stimulating hormone (FSH), thereby preventing ovulation. It also thickens cervical mucus and alters the endometrium, reducing fertilisation and implantation.

The prescribed regimen for Liofora is determined by the treating clinician. Typically, the product is supplied as a tablet containing drospirenone 3 mg and ethinylestradiol 20 µg to be taken once daily for a 21‑day active phase followed by a hormone‑free interval, but the exact schedule must be set by a qualified health‑care professional.

Liofora is contraindicated during pregnancy because it is intended to prevent conception. If pregnancy occurs, the product should be discontinued immediately. Limited data are available for use while breastfeeding; most guidelines advise avoiding combined oral contraceptives during lactation, especially in the early postpartum period, unless the benefits outweigh potential risks.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity of Liofora tablets. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation. The team coordinates delivery in compliance with international regulations.

Liofora contains drospirenone, which offers anti‑mineralocorticoid and anti‑androgenic properties that may result in a lower risk of water retention and acne compared with some other progestins. Efficacy in preventing pregnancy is comparable to other combined oral contraceptives, while the side‑effect profile may differ slightly, making it a suitable alternative for women seeking these specific hormonal characteristics.

Liofora tablets should be stored at ambient temperature, below 25 °C (77 °F). Keep the product in its original blister pack or container, protect it from moisture and direct sunlight, and ensure that it is out of reach of children. Do not use tablets that have been exposed to excessive heat or humidity.

Liofora is taken orally, usually once each day at the same time, with or without food. The typical regimen consists of 21 consecutive active tablets followed by a 7‑day hormone‑free interval, during which withdrawal bleeding occurs. Patients should not miss doses and should follow the prescribing clinician’s instructions for any missed tablets to maintain contraceptive effectiveness.

The most serious risks include venous thromboembolism (deep‑vein thrombosis or pulmonary embolism), arterial thrombosis (stroke or myocardial infarction), severe hypertension, liver disorders and gallbladder disease. These events are rare but can be life‑threatening. Women with a history of clotting disorders, smoking, age over 35, or certain medical conditions should be evaluated carefully before initiating therapy.

Liofora is contraindicated in women who are pregnant, have known or suspected thromboembolic disease, estrogen‑dependent tumors (such as certain breast cancers), uncontrolled hypertension, severe liver disease, or a history of stroke. It should also be avoided in women who are breastfeeding during the early postpartum period unless a risk‑benefit assessment supports use. Patients with known hypersensitivity to drospirenone, ethinylestradiol or any tablet excipients must not take the product.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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