Product image of Liofora (Drospirenone, Ethinylestradiol) supplied by GNH India

Liofora

Active Ingredient:
Drospirenone, Ethinylestradiol
Origin:
EU

Liofora (Drospirenone, Ethinylestradiol)

Drospirenone/Ethinylestradiol, the active ingredients in Liofora, are a combined oral contraceptive presented as a tablet for oral use. They prevent pregnancy by inhibiting ovulation and altering cervical mucus in women of reproductive age, and providing reliable birth control through hormonal regulation.

GNH India supplies Liofora as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable sourcing for global healthcare providers, offering consistent batch release, traceability, and regulatory support throughout the supply chain.

Manufacturer / TM Owner

Bayer Hispania Sl

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Indications & Clinical Uses

Liofora, a combined oral contraceptive, acts on the hormonal regulation pathway to prevent pregnancy.

  • Prevention of pregnancy: Provides reliable contraception for women of childbearing potential.
  • Treatment of moderate acne: Helps reduce acne lesions while offering contraceptive protection.
  • Management of menstrual disorders: Improves cycle regularity and reduces heavy or irregular bleeding.

How It Works

  • Drospirenone is a synthetic progestogen with anti‑mineralocorticoid and anti‑androgenic activity, while ethinylestradiol is a synthetic estrogen. Together they bind to progesterone and estrogen receptors, suppressing the hypothalamic‑pituitary‑ovarian axis, which inhibits the surge of luteinizing hormone and follicle‑stimulating hormone, preventing ovulation. The progestogenic component also thickens cervical mucus and alters the endometrial lining, reducing the chance of implantation.

Side Effects

Liofora may cause a range of adverse reactions, which are generally categorized by frequency and severity.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Headache: tension‑type or migraine‑like pain.
  • Breast tenderness: swelling or discomfort of the breasts.
  • Weight gain: slight increase in body weight, often due to fluid retention.

Serious or Rare Side Effects

  • Venous thromboembolism: blood clots in deep veins or lungs.
  • Hypertension: significant increase in blood pressure.
  • Liver dysfunction: abnormal liver enzyme levels or jaundice.

Precautions & Warnings

Before prescribing Liofora, healthcare professionals should consider several precautionary measures to ensure safe use.

  • Smoking status: Avoid use in women over 35 who smoke due to increased cardiovascular risk.
  • Cardiovascular history: Assess for hypertension, thromboembolic disorders, or coronary artery disease.
  • Liver function: Evaluate hepatic impairment as metabolism may be affected.
  • Migraine with aura: Contraindicated in patients experiencing migraine with visual disturbances.
  • Concomitant medications: Review use of enzyme‑inducing drugs that may reduce efficacy.
  • Store at ambient temperature: Keep tablets below 25 °C in the original packaging, protected from moisture and light.

Avoid Interactions

Liofora can interact with other medicines, altering its effectiveness or increasing adverse effects.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers: Antiepileptics such as carbamazepine or rifampicin can markedly reduce hormone levels.
  • Anticoagulants: Combined oral contraceptives may enhance the effect of warfarin, requiring close monitoring.
  • Certain antibiotics: Griseofulvin may decrease contraceptive efficacy.

Moderate Interactions (Monitor Closely)

  • Antifungals: Ketoconazole can increase hormone concentrations, raising side‑effect risk.
  • St. John’s wort: May modestly lower contraceptive effectiveness.
  • Antidepressants: Selective serotonin reuptake inhibitors may increase the risk of mood changes.

Frequently Asked Questions

Liofora is a combined oral contraceptive indicated for the prevention of pregnancy in women of reproductive age. It provides reliable birth control by suppressing ovulation and creating an environment that is unfavorable for fertilization and implantation.

Drospirenone acts as a progestogen with anti‑mineralocorticoid and anti‑androgenic properties, while ethinylestradiol is a synthetic estrogen. Together they bind to progesterone and estrogen receptors, suppressing the hypothalamic‑pituitary‑ovarian axis, which blocks the LH and FSH surge needed for ovulation and also thickens cervical mucus and alters the endometrium.

The dosing regimen for Liofora is determined by the prescribing healthcare professional. Typically, it involves taking one tablet daily at the same time each day, but the exact schedule and any missed‑dose instructions should be confirmed with the prescriber.

Liofora is contraindicated during pregnancy because it is intended to prevent conception. Women who become pregnant should discontinue the product. Limited data are available for breastfeeding; generally, combined oral contraceptives are considered compatible with lactation, but the prescriber should evaluate risks and benefits for each individual.

To order Liofora, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Liofora contains drospirenone, which offers anti‑mineralocorticoid and anti‑androgenic effects that may reduce water retention and improve acne compared with some other progestins. Its efficacy in preventing pregnancy is comparable to other combined oral contraceptives, but individual tolerability and side‑effect profiles can differ, so clinicians choose based on patient needs.

Liofora tablets should be stored at ambient temperature, below 25 °C (77 °F). Keep them in the original blister pack, protected from moisture, heat, and direct light. Do not store in the bathroom or near a kitchen sink, and keep out of reach of children.

Liofora is taken orally as a tablet. The usual practice is to swallow one tablet each day, preferably at the same time each day, with or without food. If a dose is missed, follow the prescriber’s instructions or the product’s patient information leaflet for appropriate action.

The most serious risks include venous thromboembolism (blood clots), arterial thrombosis (stroke or heart attack), and hypertension. These events are more likely in women who smoke, are over 35, have a history of clotting disorders, or have uncontrolled high blood pressure. Prompt medical attention is required if symptoms of clotting appear.

Liofora should not be used by women who are pregnant, have known or suspected breast cancer, have a history of thromboembolic disease, uncontrolled hypertension, severe liver disease, or who are smokers over the age of 35. It is also contraindicated in patients with migraine with aura or known hypersensitivity to any component of the tablet.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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