Product image of Lionova (Baclofen) supplied by GNH India

Lionova

Active Ingredient:
Baclofen
Origin:
EU

Lionova (Baclofen)

Baclofen, the active ingredient in Lionova, is a muscle relaxant presented as a solution for intrathecal use. It treats spasticity associated with multiple sclerosis and spinal cord injury by reducing abnormal muscle tone.

GNH India supplies Lionova as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Alternova A/S

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Indications & Clinical Uses

Baclofen is indicated for conditions involving abnormal muscle tone within the central nervous system.

  • Multiple sclerosis‑related spasticity: reduces muscle stiffness and improves functional mobility.
  • Spinal cord injury‑related spasticity: diminishes involuntary muscle contractions and facilitates rehabilitation.
  • Cerebral palsy‑related spasticity: helps control muscle rigidity and supports motor development.

How It Works

  • Baclofen acts as an agonist at GABA_B receptors in the spinal cord, enhancing inhibitory neurotransmission. Activation of these metabotropic receptors decreases calcium influx and suppresses excitatory neurotransmitter release, leading to reduced firing of alpha‑motor neurons and attenuation of spinal reflex arcs that cause spasticity.

Side Effects

Baclofen may cause a range of adverse reactions, most of which are dose‑related and reversible upon adjustment.

Common Side Effects

  • Dizziness: sensation of light‑headedness or unsteadiness.
  • Drowsiness: increased sleepiness, especially after initiation.
  • Weakness: reduced muscle strength or fatigue.
  • Nausea: mild gastrointestinal upset.

Serious or Rare Side Effects

  • Hypotension: significant drop in blood pressure requiring monitoring.
  • Respiratory depression: slowed breathing, particularly with high intrathecal doses.
  • Seizures: rare occurrence, especially if therapy is abruptly stopped.
  • Allergic reactions: rash, itching, or anaphylaxis.
  • Hallucinations: visual or auditory disturbances.

Precautions & Warnings

Before initiating intrathecal baclofen therapy, clinicians should consider several safety measures.

  • Renal function assessment: adjust dosing in patients with impaired clearance.
  • Sedation monitoring: observe for excessive drowsiness or respiratory compromise.
  • Discontinuation plan: avoid abrupt cessation to prevent rebound spasticity.
  • Epilepsy caution: monitor seizure frequency in patients with a history of seizures.
  • Concomitant CNS depressants: use with caution when combined with other sedatives.
  • Store at ambient temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Baclofen can interact with other medications that affect the central nervous system or alter its metabolism.

Major Interactions (Avoid)

  • CNS depressants (e.g., benzodiazepines): may cause profound sedation or respiratory depression.
  • Alcohol: enhances drowsiness and impairs coordination.
  • Opioids: synergistic effect on respiratory drive and sedation.

Moderate Interactions (Monitor Closely)

  • CYP450 inhibitors (e.g., erythromycin): may increase baclofen plasma levels.
  • Diuretics: can potentiate hypotensive effects.
  • Antihistamines: may augment sedation, requiring dose adjustment.

Frequently Asked Questions

Lionova contains baclofen, which is prescribed to manage spasticity associated with multiple sclerosis, spinal cord injury, and other neurological conditions that cause abnormal muscle tone. By reducing involuntary muscle contractions, it helps improve mobility and comfort for patients with these disorders.

Baclofen acts as an agonist at GABA_B receptors in the spinal cord. This activation enhances inhibitory signaling, decreasing calcium influx and suppressing excitatory neurotransmitter release, which in turn reduces the activity of motor neurons responsible for spastic muscle contractions.

The dosage of intrathecal baclofen is individualized. A qualified prescriber determines the appropriate starting dose and titration schedule based on the patient’s clinical condition, response, and tolerance. Dosing adjustments are made under medical supervision.

The safety of intrathecal baclofen in pregnancy and lactation has not been definitively established. It should be used only if the potential benefit justifies any potential risk to the fetus or infant, and the decision must be made by the treating physician.

To request Lionova, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Compared with oral baclofen, intrathecal delivery of Lionova provides higher local concentrations at the spinal cord with lower systemic exposure, often resulting in better spasticity control and fewer systemic side effects. Alternatives such as tizanidine or botulinum toxin have different mechanisms and administration routes.

Lionova should be stored at ambient temperature, below 25 °C, in its original container. Protect the product from moisture, direct sunlight, and extreme temperature fluctuations to maintain stability and potency.

Lionova is administered via an implanted intrathecal pump that delivers a controlled dose of baclofen directly into the cerebrospinal fluid. The procedure is performed by a qualified specialist, and the pump is programmed and refilled according to the patient’s therapeutic needs.

Serious risks include respiratory depression, severe hypotension, seizures, and rare allergic reactions such as anaphylaxis. Patients should be monitored closely for signs of these events, especially during dose adjustments or when combined with other central nervous system depressants.

Lionova is contraindicated in patients with known hypersensitivity to baclofen or any formulation components. Caution is advised for individuals with severe renal impairment, uncontrolled epilepsy, or those taking multiple CNS depressants without close medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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