Lioresal (Baclofen)

Baclofen works by binding to GABA_B receptors in the spinal cord. This activation reduces the release of excitatory neurotransmitters, leading to hyperpolarization of neurons and a decrease in motor neuron firing. The net effect is a reduction in muscle tone and spasticity.

The dose of Lioresal is individualized and determined by the prescribing clinician based on the patient’s condition, severity of spasticity, and response to therapy. Dosing is typically titrated using an implanted infusion pump, and exact amounts are specified in the medical order.

Safety data for intrathecal baclofen during pregnancy and lactation are limited. The product is classified as having an unknown pregnancy category, so clinicians must weigh potential benefits against possible risks to the fetus or infant before prescribing.

To order Lioresal, submit an enquiry on the product page at gnhindia.com, indicating the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request trade or institutional credentials before providing pricing, availability, shipping details (including any cold‑chain requirements) and import documentation.

Lioresal delivers baclofen directly into the cerebrospinal fluid, offering more consistent spinal cord concentrations than oral baclofen, which can be limited by systemic side effects. Compared with other intrathecal agents such as tizanidine, baclofen has a well‑established efficacy profile and is the most commonly used intrathecal antispastic medication.

Lioresal should be stored at ambient temperature, below 25 °C, in its original sealed container. Protect the solution from light, moisture and extreme temperature fluctuations. Once the vial is opened, follow aseptic technique and use within the time frame specified by the manufacturer.

Lioresal is administered via an implanted intrathecal infusion pump that delivers the baclofen solution directly into the spinal fluid. The pump is surgically placed under the skin, and dosing is programmed by a qualified healthcare professional. Administration is performed by trained personnel in a clinical setting.

Serious risks include respiratory depression, severe hypotension, seizures, and allergic reactions such as anaphylaxis. Sudden discontinuation can also lead to withdrawal symptoms, including high fever, agitation, and hallucinations. Patients should be monitored closely for these events, especially during dose adjustments.

Lioresal is contraindicated in patients with known hypersensitivity to baclofen or any component of the formulation. Caution is advised in individuals with severe renal impairment, uncontrolled epilepsy, or those taking multiple central nervous system depressants. The decision to use Lioresal should be made by a qualified physician after evaluating these factors.