Lioresal (Baclofen)

Baclofen acts as an agonist at GABA_B receptors in the spinal cord. Activation of these receptors inhibits the release of excitatory neurotransmitters, decreasing neuronal firing rates and leading to a reduction in muscle hypertonicity and spasticity.

The dosage of Lioresal is individualized. A prescriber determines the appropriate starting dose and titration schedule based on the patient’s condition, response, and tolerability. Patients should follow the prescribing clinician’s instructions and not adjust the dose on their own.

Safety data for baclofen in pregnancy and lactation are limited. Healthcare providers should weigh potential benefits against possible risks and discuss them with the patient. If prescribed, the drug should be used only when clearly needed and under medical supervision.

To request Lioresal, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Baclofen is a GABA_B agonist, whereas other antispastic drugs such as tizanidine act on α2‑adrenergic receptors. Baclofen’s mechanism provides a direct reduction of excitatory neurotransmission in the spinal cord, often resulting in a predictable dose‑response profile, but individual response and side‑effect tolerance may differ.

Lioresal should be stored at room temperature, below 25 °C. Keep the tablets in the original packaging, protect them from moisture, heat, and direct sunlight to maintain product stability throughout its shelf life.

Lioresal is taken orally, usually as a tablet. It is swallowed with water and can be taken with or without food, depending on the prescriber’s guidance. Doses are typically started low and increased gradually to achieve the desired therapeutic effect.

Serious risks include seizures, severe hypotension, respiratory depression, and rare allergic reactions such as anaphylaxis. Patients should be monitored for these events, especially when initiating therapy, adjusting doses, or combining baclofen with other central nervous system depressants.

Lioresal is contraindicated in individuals with known hypersensitivity to baclofen or any of its excipients. Caution is advised for patients with severe renal or hepatic impairment, uncontrolled epilepsy, or those taking other potent CNS depressants, unless a healthcare professional determines it is safe.