Lioresal (Baclofen)

Baclofen works by activating GABA_B receptors in the spinal cord and brainstem. This activation dampens excitatory neurotransmitter release and suppresses reflex pathways, leading to a decrease in muscle tone and spasticity. The overall effect is a smoother, more controlled muscular response.

The dosage of Lioresal is individualized. A qualified prescriber determines the appropriate starting dose and any subsequent titration based on the patient’s condition, response, and renal function. Patients should follow the prescribing information provided by their healthcare professional.

Safety data for baclofen in pregnancy and lactation are limited. The drug should only be used when the potential benefit justifies any possible risk to the fetus or infant. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss risks and alternatives with their physician.

To request Lioresal, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lioresal (baclofen) is a GABA_B agonist, whereas alternatives such as tizanidine act on α2‑adrenergic receptors and diazepam enhances GABA_A activity. Baclofen is often preferred for its targeted spinal action and lower risk of dependence, while tizanidine may cause more dry‑mouth effects and diazepam carries higher sedation and abuse potential.

Store Lioresal tablets at ambient temperature, preferably below 25 °C. Keep the tablets in the original packaging to protect them from moisture and direct sunlight. Do not store in bathrooms or near heat sources, and keep out of reach of children.

Lioresal is supplied as oral tablets. Patients should swallow the tablet whole with water, preferably with food to reduce gastrointestinal upset. The tablet should not be crushed, chewed, or split unless specifically instructed by a healthcare professional.

Serious adverse reactions include seizures, severe confusion or hallucinations, respiratory depression (especially when combined with other depressants), marked hypotension, and allergic reactions such as rash or anaphylaxis. Patients should seek immediate medical attention if any of these symptoms develop.

Lioresal is contraindicated in individuals with known hypersensitivity to baclofen or any tablet excipients. Caution is also advised for patients with severe renal impairment, uncontrolled epilepsy, or those taking multiple CNS depressants. Pregnant or breastfeeding women should only use it after thorough risk‑benefit evaluation by their physician.