Lioresal (Baclofen)

Baclofen acts as an agonist at GABA_B receptors in the spinal cord. Activation of these receptors inhibits the release of excitatory neurotransmitters, decreasing neuronal firing and consequently reducing the excessive muscle activity that characterises spasticity.

The appropriate dose of Lioresal is individualized and set by a qualified prescriber based on the patient’s condition, response, and tolerability. Dosage adjustments are made gradually to achieve optimal therapeutic effect while minimizing side effects.

Safety data for baclofen in pregnancy and lactation are limited, and the product is classified as having an unknown pregnancy category. Healthcare providers should weigh potential benefits against risks and consider alternative therapies when appropriate.

To request Lioresal, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Lioresal (baclofen) is a GABA_B receptor agonist, whereas alternatives such as tizanidine act on alpha‑2 adrenergic receptors. Baclofen is often preferred for its oral formulation and well‑characterised efficacy, while tizanidine may cause more pronounced hypotension and dry mouth. Choice depends on patient profile and tolerability.

Lioresal should be stored at room temperature, below 25 °C, in its original packaging. Protect the product from moisture and direct sunlight to maintain stability throughout its shelf life.

Lioresal is taken orally, usually in tablet form, with or without food as directed by the prescriber. The medication is swallowed whole and not crushed or chewed unless specifically instructed.

Serious adverse events include seizures, hallucinations, and respiratory depression. These reactions are rare but require immediate medical attention. Patients should be monitored closely, especially when initiating therapy or adjusting the dose.

Lioresal is contraindicated in individuals with a known hypersensitivity to baclofen or any of its excipients. Caution is also advised for patients with severe renal or hepatic impairment, and it should be avoided in those who cannot safely discontinue the drug under medical supervision.