Lioresal (Baclofen)

Baclofen binds to GABA_B receptors in the spinal cord, which inhibits the release of excitatory neurotransmitters. This action dampens the reflex arcs that cause involuntary muscle contraction, leading to a reduction in spasticity and improved muscle control.

The appropriate dose of Lioresal is determined by the prescribing clinician based on the individual’s medical condition, response to therapy and any co‑existing health issues. Dosage titration is typically started low and increased gradually under medical supervision.

Safety data for baclofen in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and this decision must be made by a qualified health professional.

To request Lioresal, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lioresal (baclofen) is a GABA_B receptor agonist, whereas other antispasmodics such as tizanidine act on α2‑adrenergic receptors. Baclofen’s mechanism provides a direct reduction of spinal reflex activity, often resulting in a distinct side‑effect profile and dosing considerations compared with alternatives.

Lioresal should be stored at room temperature, below 25 °C, in its original packaging. Keep the product away from moisture, direct sunlight and excessive heat to maintain its stability and potency.

Lioresal is taken orally, usually in tablet form, with or without food as directed by the prescriber. The exact timing and frequency depend on the individualized dosing regimen established by the treating physician.

Serious risks include seizures, severe hypotension, respiratory depression, hallucinations or other neuropsychiatric events, and allergic reactions such as rash or angioedema. Patients should be monitored closely for any of these symptoms, especially during dose adjustments.

Lioresal is contraindicated in individuals with known hypersensitivity to baclofen or any of its excipients. Caution is also advised for patients with severe renal or hepatic impairment, uncontrolled epilepsy, or those taking other central nervous system depressants without proper medical oversight.