Lioresal (Baclofen)

Baclofen works by activating GABA_B receptors in the spinal cord. This activation inhibits excitatory neurotransmitter release and reduces neuronal firing, which dampens reflex arcs and lowers excessive muscle contraction, thereby decreasing spasticity.

The dose of Lioresal is individualized. A qualified prescriber determines the appropriate starting dose, titration schedule, and maximum daily amount based on the patient’s condition, response, and tolerability.

The safety of baclofen in pregnancy and lactation has not been definitively established. Healthcare providers weigh potential benefits against unknown risks, and women who are pregnant, planning pregnancy, or breastfeeding should discuss use with their physician.

To order Lioresal, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lioresal (baclofen) is a GABA_B receptor agonist, whereas alternatives such as tizanidine act on α2‑adrenergic receptors. Baclofen is often preferred for its oral formulation and specific spinal cord action, while tizanidine may cause more dry‑mouth side effects. Choice depends on patient response, comorbidities, and physician judgment.

Lioresal tablets should be stored at ambient temperature, below 25 °C, in the original packaging to protect them from moisture and light. Keep the product out of reach of children and avoid storing in humid or excessively hot environments.

Lioresal is taken orally as a tablet. Patients should swallow the tablet whole with a glass of water, preferably with food to reduce gastrointestinal discomfort. The exact timing and frequency are set by the prescribing clinician.

Serious adverse reactions, although uncommon, include seizures, hallucinations, severe hypotension, respiratory depression, and allergic responses such as rash or angioedema. Patients should seek immediate medical attention if they experience any of these symptoms.

Lioresal is contraindicated in individuals with known hypersensitivity to baclofen or any tablet excipients. Caution is advised for patients with severe renal or hepatic impairment, uncontrolled epilepsy, or those taking other central nervous system depressants without close monitoring.