Product image of Lioresal (Baclofen) supplied by GNH India

Lioresal

Active Ingredient:
Baclofen
Origin:
EU

Lioresal (Baclofen)

Baclofen, the active ingredient in Lioresal, is a muscle relaxant presented as a tablet for oral use. It acts as an antispastic agent that reduces muscle tone and spasm in patients with neurological disorders such as multiple sclerosis, spinal cord injury, cerebral palsy and other conditions causing spasticity.

GNH India supplies Lioresal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to EU quality standards and provides reliable sourcing for bulk and retail needs across global markets.

Manufacturer / TM Owner

Novartis Europharm Limited

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Indications & Clinical Uses

Baclofen is used as an antispastic agent to manage spasticity in various neurological disorders.

  • Multiple sclerosis: reduces muscle spasticity and improves mobility in affected patients.
  • Spinal cord injury: diminishes involuntary muscle contractions and facilitates rehabilitation.
  • Cerebral palsy: lessens tone abnormalities, aiding functional movement.
  • Other neurological conditions causing spasticity: provides overall reduction of muscle stiffness and improves daily activities.

How It Works

  • Baclofen acts as an agonist at GABA_B receptors in the spinal cord, inhibiting the release of excitatory neurotransmitters. This reduces neuronal firing in motor pathways, leading to decreased muscle tone and spasm. The drug’s central action modulates synaptic transmission, thereby providing antispastic effects without significant peripheral activity.

Side Effects

Baclofen may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Dizziness: feeling light‑headed or unsteady.
  • Drowsiness: increased sleepiness, especially after dosing.
  • Weakness: reduced muscle strength or fatigue.
  • Nausea: upset stomach or urge to vomit.

Serious or Rare Side Effects

  • Seizures: convulsive episodes requiring immediate medical attention.
  • Hallucinations: visual or auditory disturbances.
  • Severe hypotension: marked drop in blood pressure.
  • Respiratory depression: slowed breathing that may be life‑threatening.

Precautions & Warnings

When prescribing baclofen, several safety considerations should be observed.

  • Renal impairment: adjust dose or monitor closely due to reduced clearance.
  • Hepatic dysfunction: use with caution as metabolism may be altered.
  • Concomitant CNS depressants: increased risk of excessive sedation.
  • Abrupt discontinuation: may precipitate withdrawal symptoms such as agitation or tachycardia.
  • Pregnancy: safety not established; benefits must outweigh potential risks.
  • Store at ambient temperature: keep in the original pack, protect from moisture and light.

Avoid Interactions

Baclofen can interact with other medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Alcohol: additive central nervous system depression.
  • Opioids: heightened risk of respiratory depression and profound sedation.
  • Anticonvulsants (e.g., carbamazepine): may lower baclofen plasma concentrations.

Moderate Interactions (Monitor Closely)

  • Antihypertensives: potential additive hypotensive effect.
  • CYP450 inhibitors (e.g., erythromycin): may increase baclofen exposure and side‑effect risk.

Frequently Asked Questions

Lioresal contains baclofen, which is prescribed to reduce muscle spasticity in conditions such as multiple sclerosis, spinal cord injury, cerebral palsy and other neurological disorders that cause abnormal muscle tone.

Baclofen binds to GABA_B receptors in the spinal cord, decreasing the release of excitatory neurotransmitters. This action dampens neuronal firing in motor pathways, leading to a reduction in muscle stiffness and involuntary contractions.

The appropriate dose of Lioresal is determined by the prescribing clinician based on the patient’s condition, response, and tolerance. Dosage adjustments are made individually, and patients should follow the prescriber’s instructions exactly.

Safety data for baclofen in pregnancy and lactation are limited. The drug should only be used when the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by the treating physician.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Baclofen is a GABA_B receptor agonist, whereas alternatives such as tizanidine act on α2‑adrenergic receptors. Baclofen’s oral tablet form offers convenient dosing, but individual response and side‑effect profiles vary, so clinicians choose the agent that best matches the patient’s therapeutic goals.

Lioresal tablets should be stored at ambient temperature, below 25 °C, in their original container. Protect them from moisture, excessive heat and direct sunlight to maintain product stability throughout its shelf life.

Lioresal is taken orally as a tablet, usually with a glass of water. The exact timing and frequency are set by the prescriber, who may start with a low dose and gradually increase it based on therapeutic response and tolerability.

Serious risks include seizures, hallucinations, severe hypotension, and respiratory depression, especially when combined with other central nervous system depressants. Patients should be monitored closely for these events, and any sudden changes in condition require immediate medical attention.

Lioresal is contraindicated in patients with known hypersensitivity to baclofen or any tablet excipients. Caution is also advised for individuals with severe renal or hepatic impairment, uncontrolled epilepsy, or those taking interacting CNS depressants without close supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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