Lioresal (Baclofen)

Baclofen binds to GABA_B receptors in the spinal cord and brainstem, activating inhibitory pathways that decrease the release of excitatory neurotransmitters. This action dampens spinal reflexes, leading to a reduction in muscle tone and spastic contractions.

The dosage of Lioresal is individualized by the prescribing clinician based on the patient’s condition, response, and tolerability. The prescriber determines the appropriate starting dose and titration schedule, which may be adjusted over time.

Safety data for baclofen in pregnancy and lactation are limited. Healthcare providers should weigh the potential benefits against possible risks before prescribing Lioresal to pregnant or nursing individuals. Consultation with a specialist is recommended.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Lioresal (baclofen) is a GABA_B receptor agonist, whereas alternatives like tizanidine act on α2‑adrenergic receptors. Baclofen’s mechanism provides direct inhibition of spinal reflexes, often resulting in a different side‑effect profile, such as more pronounced sedation but less dry mouth compared with tizanidine.

Lioresal should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in their original packaging, protect them from moisture and direct sunlight, and ensure they are out of reach of children.

Lioresal is taken orally, usually with a glass of water. It can be swallowed whole or, if necessary, divided according to the prescriber’s instructions. Patients should follow the dosing schedule provided by their healthcare professional.

Serious adverse events, though uncommon, include seizures, respiratory depression, severe hypotension, and allergic reactions such as rash or swelling. Patients should seek immediate medical attention if they experience any of these symptoms.

Lioresal is contraindicated in individuals with known hypersensitivity to baclofen or any excipients in the formulation. Caution is also advised for patients with severe renal or hepatic impairment, uncontrolled epilepsy, or those taking other central nervous system depressants without close monitoring.