Lioresal (Baclofen)

Baclofen binds to GABA_B receptors in the spinal cord and brain, decreasing the release of excitatory neurotransmitters. This inhibition dampens spinal reflexes, leading to reduced muscle tone and lessened spasticity.

The dosage of Lioresal is individualized. A qualified prescriber determines the appropriate starting dose and titration schedule based on the patient’s condition, response, and tolerance. Patients should follow the prescribing physician’s instructions.

The safety of baclofen in pregnancy and lactation has not been established. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and under close medical supervision.

To request Lioresal, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and necessary import documentation.

Baclofen is a GABA_B agonist, whereas alternatives such as tizanidine act on alpha‑2 adrenergic receptors and diazepam enhances GABA_A activity. Baclofen’s mechanism provides targeted reduction of spinal reflexes, often resulting in fewer sedative effects compared with benzodiazepines, but individual response varies.

Lioresal tablets should be stored at ambient temperature, below 25 °C. Keep them in the original packaging, protect from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability.

Lioresal is taken orally as a tablet. Patients should swallow the tablet whole with water, preferably at the same times each day. The prescriber may adjust the dose gradually to achieve the desired therapeutic effect while monitoring tolerance.

Serious risks include seizures, severe hypotension, respiratory depression, and allergic reactions such as rash or angioedema. Patients should seek immediate medical attention if they experience any of these symptoms while on baclofen.

Lioresal is contraindicated in individuals with known hypersensitivity to baclofen or any tablet excipients. Caution is advised for patients with severe renal or hepatic impairment, uncontrolled epilepsy, or those taking other central nervous system depressants without medical supervision.