Lioresal Intrathecal (Baclofen)

Baclofen acts as an agonist at GABA_B receptors in the spinal cord. By activating these inhibitory receptors, it reduces the release of excitatory neurotransmitters, dampening spinal reflex activity. This leads to a decrease in muscle hyperactivity and spasticity, improving patient mobility and comfort.

The dosing regimen for Lioresal Intrathecal is individualized and determined by the prescribing specialist. Doses are titrated based on clinical response and tolerability, with adjustments made through the implanted pump system under professional supervision.

Safety data for intrathecal baclofen in pregnancy and lactation are limited. The product carries an unknown pregnancy category, and clinicians must evaluate potential risks versus benefits. Breastfeeding considerations should also be discussed with a healthcare provider.

To request Lioresal Intrathecal, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and import documentation.

Intrathecal baclofen delivers the drug directly to the spinal cord, achieving higher local concentrations with lower systemic exposure compared with oral baclofen. This often results in greater spasticity control and fewer systemic side effects, making it suitable for patients who do not respond adequately to oral therapy.

Lioresal Intrathecal should be stored at 2‑8 °C in a refrigerator, protected from light, and must not be frozen or shaken. Maintain the cold chain during transport and keep the solution in its original packaging until use.

The product is administered via an implanted intrathecal pump that delivers a continuous, programmable infusion of baclofen into the cerebrospinal fluid. A qualified clinician performs the surgical implantation and subsequent pump programming.

Serious risks include respiratory depression, severe hypotension, seizures, catheter‑site infections, hallucinations, and rare anaphylactic reactions. Prompt medical attention is required if any of these events occur.

Patients with known hypersensitivity to baclofen or any formulation component should avoid the product. It is also contraindicated in individuals with severe renal failure, uncontrolled infection at the catheter site, or those for whom intrathecal therapy is medically inappropriate.