Product image of Lioresal Intrathecal (Baclofen) supplied by GNH India

Lioresal Intrathecal

Active Ingredient:
Baclofen
Origin:
EU

Lioresal Intrathecal (Baclofen)

Baclofen, the active ingredient in Lioresal Intrathecal, is a GABA_B receptor agonist presented as an intrathecal solution for intrathecal use. It is employed to treat spasticity associated with multiple sclerosis, spinal cord injury, and cerebral palsy.
GNH India supplies Lioresal Intrathecal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Novartis Pharma N.V.

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Indications & Clinical Uses

  • Lioresal Intrathecal acts on the central nervous system to reduce abnormal muscle tone in various neurological conditions.
  • Multiple sclerosis–related spasticity: reduces muscle tone and improves mobility.
  • Spinal cord injury–associated spasticity: decreases involuntary muscle contractions.
  • Cerebral palsy spasticity: alleviates stiffness and facilitates functional movement.

How It Works

  • Baclofen binds to GABA_B receptors in the spinal cord, activating inhibitory G‑protein pathways that lower calcium influx and suppress the release of excitatory neurotransmitters. This results in reduced neuronal firing and decreased muscle tone, helping to control spasticity.

Side Effects

Adverse reactions may occur with intrathecal baclofen therapy.

Common Side Effects

  • Dizziness
  • Fatigue
  • Headache
  • Nausea
  • Constipation
  • Injection‑site irritation

Serious or Rare Side Effects

  • Hypotension
  • Respiratory depression
  • Seizures
  • Severe allergic reactions (anaphylaxis)
  • Urinary retention
  • Hallucinations or psychosis

Precautions & Warnings

  • When using Lioresal Intrathecal, consider the following safety measures.
  • Renal impairment: monitor renal function and adjust therapy as needed.
  • Hepatic impairment: use with caution and observe liver parameters.
  • Concomitant CNS depressants: increased risk of sedation and respiratory depression.
  • Pregnancy: safety not established; avoid unless benefits outweigh risks.
  • Abrupt discontinuation: may cause severe withdrawal symptoms; taper under medical supervision.
  • Store at ambient temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Baclofen may interact with several drug classes; awareness helps prevent adverse outcomes.

Major Interactions (Avoid)

  • Opioids: additive central nervous system depression.
  • Benzodiazepines: enhanced sedation and respiratory depression.
  • Antihypertensives: increased risk of hypotension.

Moderate Interactions (Monitor Closely)

  • Anticonvulsants: may alter baclofen plasma levels.
  • Alcohol: potentiates sedative effects.
  • CYP450 inhibitors: possible increase in baclofen exposure.

Frequently Asked Questions

Lioresal Intrathecal is prescribed to manage spasticity in patients with multiple sclerosis, spinal cord injury, and cerebral palsy. By reducing abnormal muscle tone, it helps improve mobility and functional ability in these neurological disorders.

Baclofen activates GABA_B receptors in the spinal cord, which inhibits excitatory neurotransmitter release and dampens neuronal firing. This inhibition lowers muscle tone and reduces involuntary muscle contractions that cause spasticity.

The specific dose of Lioresal Intrathecal is determined by the prescribing clinician based on the patient’s condition, response, and tolerance. Dosing is individualized and administered via an implanted intrathecal pump.

Safety data for intrathecal baclofen in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and decisions are made in consultation with a healthcare professional.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and import documentation.

Intrathecal baclofen delivers the drug directly to the spinal fluid, allowing lower total doses and fewer systemic side effects compared with oral baclofen, which must cross the blood‑brain barrier and often requires higher doses that can cause more widespread adverse effects.

Store the intrathecal solution at ambient temperature, preferably below 25 °C, in its original sealed container. Protect it from direct sunlight, moisture, and extreme temperature fluctuations to maintain stability.

Lioresal Intrathecal is delivered via an implanted intrathecal pump that continuously infuses the baclofen solution into the cerebrospinal fluid. The pump is surgically placed and programmed by a qualified clinician to provide precise dosing.

Serious risks include respiratory depression, severe hypotension, seizures, and rare allergic reactions such as anaphylaxis. Patients should be monitored closely for signs of these events, especially during dose adjustments.

Patients with known hypersensitivity to baclofen or any component of the formulation, those with uncontrolled severe cardiac or respiratory disease, and individuals for whom intrathecal therapy is contraindicated should not receive Lioresal Intrathecal.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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