Product image of Liothyronine Sodium Bp Mercury Pharma Group (Liothyronine Sodium) supplied by GNH India

Liothyronine Sodium Bp Mercury Pharma Group

Active Ingredient:
Liothyronine Sodium
Origin:
EU

Liothyronine Sodium Bp Mercury Pharma Group (Liothyronine Sodium)

Liothyronine Sodium, the active ingredient in Liothyronine Sodium Bp Mercury Pharma Group, is a thyroid hormone presented as an oral dosage form for oral use. It is employed to treat hypothyroidism, myxedema coma, and other conditions requiring thyroid hormone replacement in adults and children.

GNH India supplies Liothyronine Sodium Bp Mercury Pharma Group as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory‑approved batches to meet global demand.

Manufacturer / TM Owner

Mercury Pharma Group Ltd

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Indications & Clinical Uses

Liothyronine sodium is a synthetic thyroid hormone that acts on the hypothalamic‑pituitary‑thyroid axis to restore normal metabolic function.

  • Hypothyroidism: normalizes circulating thyroid hormone levels, alleviating fatigue, weight gain, and cold intolerance in patients with underactive thyroid.
  • Myxedema coma: provides rapid T3 supplementation to support cardiovascular and respiratory function in life‑threatening severe hypothyroidism.
  • Thyroid hormone replacement therapy: maintains euthyroid status in individuals who have had thyroidectomy or radioactive iodine ablation.

How It Works

  • Liothyronine sodium is the sodium salt of triiodothyronine (T3), the biologically active thyroid hormone. After oral absorption it enters the bloodstream and binds with high affinity to nuclear thyroid hormone receptors (TRα and TRβ) in target cells. Receptor activation modulates gene transcription, increasing basal metabolic rate, enhancing oxygen consumption, and influencing protein synthesis, thereby correcting the metabolic deficits of hypothyroidism.

Side Effects

Liothyronine sodium may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Palpitations: sensation of rapid or irregular heartbeat.
  • Anxiety: heightened nervousness or restlessness.
  • Headache: mild to moderate cranial pain.
  • Nausea: mild stomach upset.
  • Diarrhea: loose stools.

Serious or Rare Side Effects

  • Cardiac arrhythmias: potentially life‑threatening irregular heart rhythms.
  • Myocardial infarction: increased risk of heart attack in susceptible patients.
  • Severe hyperthyroidism: fever, tremor, and marked weight loss.
  • Severe bone loss: increased risk of osteoporosis with long‑term use.
  • Allergic reactions: rash, itching, swelling, or anaphylaxis.

Precautions & Warnings

When prescribing liothyronine sodium, clinicians should consider several safety precautions to minimize risks.

  • Cardiac disease: adjust dose and monitor heart function in patients with coronary artery disease.
  • Elderly patients: start with lower dose and titrate cautiously due to increased sensitivity.
  • Adrenal insufficiency: ensure adequate glucocorticoid replacement before initiating therapy.
  • Pregnancy and lactation: evaluate risk‑benefit ratio; use only if clearly needed.
  • Drug monitoring: regularly assess thyroid function tests to avoid over‑replacement.
  • Store at room temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Liothyronine sodium can interact with several medicines, altering its effectiveness or increasing toxicity.

Major Interactions (Avoid)

  • Antithyroid drugs (e.g., propylthiouracil, methimazole): block thyroid hormone synthesis and negate therapeutic effect.
  • Anticoagulants (warfarin): enhanced anticoagulant effect may increase bleeding risk.
  • Digoxin: increased serum digoxin levels can lead to toxicity.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may mask tachycardia and other hyperthyroid signs, requiring careful monitoring.
  • Oral contraceptives: estrogen may raise thyroid‑binding globulin, affecting hormone levels.
  • Statins: potential for altered metabolism; monitor lipid profile and thyroid function.

Frequently Asked Questions

Liothyronine sodium is used to replace or supplement thyroid hormone in patients with hypothyroidism, to treat severe forms such as myxedema coma, and to maintain euthyroid status after thyroidectomy or radioactive iodine therapy. It provides the active form of thyroid hormone (T3) to normalize metabolism and alleviate symptoms of thyroid deficiency.

The drug is the sodium salt of triiodothyronine (T3). After oral absorption it binds to nuclear thyroid hormone receptors in target cells, influencing gene transcription. This activation raises basal metabolic rate, increases oxygen consumption, and modulates protein synthesis, thereby correcting the metabolic slowdown seen in hypothyroid conditions.

Dosing of liothyronine sodium is individualized. The prescribing clinician determines the appropriate amount based on the patient’s age, weight, severity of hypothyroidism, cardiac status, and laboratory thyroid function tests. Dosage adjustments are made during follow‑up to achieve optimal hormone levels without causing excess.

Safety in pregnancy and lactation has not been fully established. The drug should be used only when the potential benefit justifies any possible risk to the fetus or infant. Physicians typically evaluate the mother’s thyroid status and may prefer levothyroxine, but liothyronine may be prescribed if rapid hormone replacement is required.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Liothyronine sodium provides the active T3 hormone, producing a faster onset of action than levothyroxine, which is a pro‑hormone (T4) that must be converted to T3. Liothyronine is often used when rapid correction is needed or when conversion of T4 to T3 is impaired. Levothyroxine remains the standard for most long‑term thyroid replacement because of its longer half‑life and more stable serum levels.

The product should be stored at room temperature, preferably below 25 °C. Keep the tablets in the original blister pack or container, protect them from moisture, heat and direct sunlight. Do not store in the bathroom or near a kitchen sink, and keep out of reach of children.

Liothyronine sodium is taken orally, usually with a glass of water. It may be taken on an empty stomach or as directed by the prescriber. The tablet should be swallowed whole; it should not be crushed, chewed, or dissolved unless specifically instructed by a healthcare professional.

Serious risks include cardiac arrhythmias, myocardial infarction, severe hyperthyroidism, and bone loss (osteoporosis) with prolonged high‑dose therapy. Patients with pre‑existing heart disease, uncontrolled hypertension, or adrenal insufficiency are particularly vulnerable and require close monitoring while on treatment.

Liothyronine sodium is contraindicated in patients with untreated adrenal insufficiency, acute myocardial infarction, or severe cardiovascular disease. It should also be avoided in individuals with known hypersensitivity to liothyronine or any of the excipients in the formulation.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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