Product image of Liothyronine Sodium Strides Pharma (Liothyronine Sodium) supplied by GNH India

Liothyronine Sodium Strides Pharma

Active Ingredient:
Liothyronine Sodium
Origin:
EU

Liothyronine Sodium Strides Pharma (Liothyronine Sodium)

Liothyronine Sodium, the active ingredient in Liothyronine Sodium Strides Pharma, is a thyroid hormone presented as an oral tablet for oral use. It is employed to treat hypothyroidism and related thyroid hormone deficiency conditions in patients requiring hormone replacement. The formulation is designed for consistent absorption and complies with EU pharmaceutical standards.

GNH India supplies Liothyronine Sodium Strides Pharma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, providing reliable sourcing and regulatory support for global distribution.

Manufacturer / TM Owner

Strides Pharma Uk Limited

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Indications & Clinical Uses

Liothyronine Sodium is used to manage disorders of thyroid hormone deficiency and associated metabolic disturbances.

  • Hypothyroidism: Restores deficient thyroid hormone levels, improving metabolism and symptom control.
  • Myxedema coma: Provides rapid thyroid hormone replacement essential for life‑threatening severe hypothyroidism.
  • Thyroid hormone replacement therapy: Maintains euthyroid state in patients after thyroidectomy or radioactive iodine treatment.

How It Works

  • Liothyronine Sodium is a synthetic form of triiodothyronine (T3) that enters cells and binds to nuclear thyroid hormone receptors (TRα and TRβ). The ligand‑receptor complex interacts with thyroid response elements on DNA, modulating transcription of genes that regulate basal metabolic rate, protein synthesis, and thermogenesis, thereby restoring normal metabolic activity in hypothyroid patients.

Side Effects

Liothyronine Sodium may cause adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Palpitations: Sensation of rapid or irregular heartbeat.
  • Tachycardia: Elevated resting heart rate.
  • Insomnia: Difficulty initiating or maintaining sleep.
  • Anxiety: Feelings of nervousness or restlessness.
  • Heat intolerance: Excessive sweating and discomfort in warm environments.
  • Weight loss: Unintended reduction in body weight.

Serious or Rare Side Effects

  • Cardiac arrhythmia: Potential for irregular heart rhythm, including atrial fibrillation.
  • Angina pectoris: Chest pain due to myocardial ischemia.
  • Myocardial infarction: Rare occurrence of heart attack.
  • Severe bone loss: Accelerated osteoporosis with prolonged high doses.
  • Anaphylactic reaction: Life‑threatening allergic response.
  • Hepatic dysfunction: Elevated liver enzymes or liver injury.

Precautions & Warnings

When prescribing Liothyronine Sodium, clinicians should consider several precautionary measures to ensure safe use.

  • Cardiac monitoring: Assess heart disease history and monitor ECG in patients with cardiovascular risk.
  • Dose adjustment: Initiate low doses in elderly or those with coronary artery disease.
  • Thyroid function tests: Regularly check serum T3, T4, and TSH levels to avoid over‑replacement.
  • Adrenal insufficiency: Ensure adequate glucocorticoid coverage before initiating therapy.
  • Pregnancy and lactation: Use only if benefits outweigh potential risks, as safety data are limited.
  • Store at ambient temperature: Keep below 25 °C in the original container, protect from moisture.

Avoid Interactions

Liothyronine Sodium can interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Levothyroxine: Combined excess thyroid hormone may cause toxicity.
  • Antithyroid drugs (e.g., methimazole): Oppose the therapeutic effect of Liothyronine.
  • Amiodarone: High iodine content can exacerbate thyroid hormone imbalance.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: May mask symptoms of thyrotoxicosis.
  • Oral contraceptives: Increase thyroid‑binding globulin, potentially requiring dose adjustment.

Frequently Asked Questions

Liothyronine Sodium is prescribed to treat hypothyroidism, provide rapid hormone replacement in myxedema coma, and serve as long‑term thyroid hormone replacement after thyroidectomy or radioactive iodine therapy. It restores deficient thyroid hormone levels, helping to normalize metabolism and alleviate related symptoms.

Liothyronine Sodium is a synthetic form of the active thyroid hormone triiodothyronine (T3). After oral absorption, it binds to nuclear thyroid hormone receptors, influencing gene transcription that regulates basal metabolic rate, protein synthesis, and heat production, thereby correcting the metabolic deficits of hypothyroidism.

The dosage of Liothyronine Sodium is individualized. A qualified prescriber determines the appropriate strength and frequency based on the patient’s clinical condition, laboratory results, age, weight, and comorbidities. Patients should follow the prescribing clinician’s instructions and not adjust the dose on their own.

Safety data for Liothyronine Sodium in pregnancy and lactation are limited. It should be used only if the potential benefit to the mother outweighs any possible risk to the fetus or infant. Healthcare providers usually prefer the most appropriate thyroid hormone regimen and monitor maternal and fetal thyroid status closely.

To order Liothyronine Sodium, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Liothyronine Sodium (T3) is the active form of thyroid hormone, while levothyroxine (T4) is a pro‑hormone that is converted to T3 in the body. T3 has a faster onset of action and a shorter half‑life, making it useful for rapid replacement, whereas levothyroxine provides more stable, long‑term hormone levels. Choice of therapy depends on clinical goals and patient response.

Liothyronine Sodium tablets should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability throughout its shelf life.

Liothyronine Sodium is taken orally, usually with a glass of water. It may be prescribed to be taken on an empty stomach or with food, depending on the prescriber’s guidance. Patients should follow the exact timing and dosing instructions provided by their healthcare professional.

Serious risks include cardiac arrhythmias, angina, myocardial infarction, severe bone loss (osteoporosis), anaphylactic reactions, and hepatic dysfunction. Patients with pre‑existing heart disease, osteoporosis, or liver disorders should be monitored closely, and any alarming symptoms should prompt immediate medical evaluation.

Liothyronine Sodium is contraindicated in patients with untreated adrenal insufficiency, acute myocardial infarction, or known hypersensitivity to the drug or its excipients. It should also be avoided in individuals where excessive thyroid hormone could exacerbate underlying conditions, unless a specialist determines that benefits outweigh the risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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