Product image of Lipanthyl (Fenofibrate) supplied by GNH India

Lipanthyl

Active Ingredient:
Fenofibrate
Origin:
EU

Lipanthyl (Fenofibrate)

Fenofibrate, the active ingredient in Lipanthyl, is a fibrate presented as a tablet for oral use. It is prescribed to lower elevated blood lipids, particularly in patients with high cholesterol or triglyceride levels, and works by modifying lipid metabolism to reduce cardiovascular risk associated with dyslipidemia.

GNH India supplies Lipanthyl as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality manufacturing standards and reliable global distribution for this essential lipid‑modifying agent.

Manufacturer / TM Owner

Viatris Sia

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Indications & Clinical Uses

  • Lipanthyl (fenofibrate) is used to treat disorders of lipid metabolism.
  • Hypercholesterolemia: reduces LDL‑cholesterol and total cholesterol levels.
  • Hypertriglyceridemia: lowers elevated triglyceride concentrations.
  • Mixed dyslipidemia: improves overall lipid profile by decreasing triglycerides and LDL while modestly raising HDL.

How It Works

  • Fenofibrate activates peroxisome proliferator‑activated receptor alpha (PPARα), a nuclear transcription factor that up‑regulates genes involved in fatty‑acid oxidation, lipoprotein lipase activity, and clearance of triglyceride‑rich particles, while decreasing hepatic production of very‑low‑density lipoprotein (VLDL). This coordinated effect leads to reduced plasma triglycerides, lowered LDL‑cholesterol, and modest increases in HDL‑cholesterol.

Side Effects

Fenofibrate may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Gastrointestinal discomfort: nausea, dyspepsia, or abdominal pain.
  • Headache: mild to moderate intensity.
  • Muscle pain: occasional myalgia without weakness.
  • Elevated liver enzymes: mild transaminase increases.
  • Elevated serum creatinine: transient rise in renal markers.
  • Skin rash: mild pruritic eruptions.

Serious or Rare Side Effects

  • Rhabdomyolysis: severe muscle breakdown with risk of renal failure.
  • Hepatotoxicity: significant liver injury or hepatitis.
  • Severe allergic reaction: anaphylaxis or angioedema.
  • Pancreatitis: acute inflammation of the pancreas.
  • Myopathy with renal impairment: exacerbated muscle toxicity in patients with reduced kidney function.
  • Gallstone formation: rare occurrence of biliary sludge or stones.

Precautions & Warnings

  • When prescribing fenofibrate, clinicians should consider several safety precautions.
  • Renal function: assess baseline kidney function and monitor periodically.
  • Liver disease: evaluate hepatic enzymes before initiation and during therapy.
  • Gallbladder disease: use with caution in patients with a history of gallstones.
  • Pregnancy: avoid unless potential benefit justifies the risk.
  • Drug interactions: review concomitant medications for possible interactions.
  • Store at ambient temperature: keep in the original packaging, protect from moisture and light.

Avoid Interactions

Fenofibrate can interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • Gemfibrozil: markedly increases risk of myopathy and rhabdomyolysis.
  • Cyclosporine: elevates fenofibrate plasma concentrations.
  • Warfarin: may enhance anticoagulant effect and increase INR.

Moderate Interactions (Monitor Closely)

  • Statins: combined use can raise the likelihood of muscle toxicity.
  • Antidiabetic agents: may affect glycemic control, requiring dose adjustments.
  • Thiazide diuretics: can increase serum uric acid levels, potentially precipitating gout.

Frequently Asked Questions

Lipanthyl contains fenofibrate, a fibrate medication indicated for the management of hypercholesterolemia, hypertriglyceridemia, and mixed dyslipidemia. It helps lower elevated blood lipids, reducing the risk of cardiovascular events in patients with abnormal lipid profiles.

Fenofibrate activates the nuclear receptor PPARα, which increases the transcription of genes involved in fatty‑acid oxidation and lipoprotein metabolism. This leads to enhanced breakdown of triglyceride‑rich particles, reduced VLDL production, and modest increases in HDL‑cholesterol, improving the overall lipid profile.

The dosage of Lipanthyl is individualized and determined by the prescribing healthcare professional based on the patient’s clinical condition, laboratory values, and response to therapy. Patients should follow the dose and schedule provided by their prescriber.

Fenofibrate is generally not recommended during pregnancy or lactation unless the potential benefit outweighs the risk to the fetus or infant. Clinicians should discuss alternative lipid‑lowering strategies with women of child‑bearing potential and advise against use while breastfeeding.

To place an order, submit an enquiry on the Lipanthyl product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

The primary alternative to fenofibrate is the statin class, which primarily lowers LDL‑cholesterol. Fenofibrate is more effective at reducing triglycerides and modestly raising HDL‑cholesterol, making it preferable for patients with predominant hypertriglyceridemia or mixed dyslipidemia, whereas statins are first‑line for isolated high LDL.

Store Lipanthyl at ambient temperature, below 25 °C, in the original container to protect it from moisture and light. Keep the product out of reach of children and do not use if the packaging is damaged or the tablets appear discolored.

Lipanthyl is taken orally, usually with a meal to improve absorption. The tablet should be swallowed whole with water and not crushed or chewed unless otherwise instructed by a healthcare professional.

Serious adverse events include rhabdomyolysis, severe liver injury, pancreatitis, and life‑threatening allergic reactions such as anaphylaxis. Patients should promptly report unexplained muscle pain, dark urine, jaundice, severe abdominal pain, or signs of an allergic response to their clinician.

Lipanthyl is contraindicated in patients with severe liver disease, active gallbladder disease, known hypersensitivity to fenofibrate or other fibrates, and in individuals with pre‑existing severe renal impairment. Caution is also advised for patients taking interacting medications such as gemfibrozil or high‑dose statins.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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