Product image of Lipanthyl (Fenofibrate) supplied by GNH India

Lipanthyl

Active Ingredient:
Fenofibrate
Origin:
EU

Lipanthyl (Fenofibrate)

Fenofibrate, the active ingredient in Lipanthyl, is a fibrate presented as an oral tablet for oral use. It is used to lower elevated triglyceride and cholesterol levels in patients with hypertriglyceridaemia, mixed dyslipidaemia, or as adjunct therapy for primary hypercholesterolaemia.

GNH India supplies Lipanthyl as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Viatris Sia

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Indications & Clinical Uses

Lipanthyl (fenofibrate) acts on lipid metabolism disorders and is indicated for the following conditions:

  • Hypertriglyceridaemia: reduces triglyceride concentrations and lowers risk of pancreatitis.
  • Mixed dyslipidaemia: decreases triglycerides and modestly raises HDL‑cholesterol while lowering LDL‑cholesterol.
  • Primary hypercholesterolaemia (adjunct therapy): enhances the lipid‑lowering effect of statins when used together.

How It Works

  • Fenofibrate activates peroxisome proliferator‑activated receptor‑alpha (PPARα) in liver and muscle cells, leading to increased transcription of genes involved in fatty‑acid oxidation, lipoprotein lipase synthesis and clearance of triglyceride‑rich lipoproteins. This results in reduced plasma triglycerides, modest increases in high‑density lipoprotein cholesterol and lowered low‑density lipoprotein cholesterol.

Side Effects

Fenofibrate may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Gastrointestinal discomfort: nausea, abdominal pain or dyspepsia.
  • Headache: mild to moderate intensity.
  • Elevated liver enzymes: transient increase in ALT or AST.

Serious or Rare Side Effects

  • Rhabdomyolysis: severe muscle breakdown that may cause renal failure.
  • Severe liver injury: hepatitis or hepatic failure.
  • Allergic reactions: rash, pruritus, angioedema or rare Stevens‑Johnson syndrome.

Precautions & Warnings

When prescribing fenofibrate, clinicians should consider several safety measures.

  • Monitor liver function: check ALT/AST before and during therapy.
  • Assess renal function: adjust use in patients with impaired kidneys.
  • Review concomitant statin therapy: increased risk of myopathy.
  • Avoid use in pregnancy: contraindicated due to fetal risk.
  • Counsel on muscle symptoms: advise patients to report unexplained muscle pain or weakness.
  • Store at room temperature: keep in original packaging, protect from moisture and light.

Avoid Interactions

Fenofibrate interacts with several medicines; some combinations should be avoided while others require monitoring.

Major Interactions (Avoid)

  • Gemfibrozil: combined use markedly increases risk of myopathy.
  • High‑dose statins (e.g., rosuvastatin >20 mg): may precipitate rhabdomyolysis.
  • Cyclosporine: elevates fenofibrate plasma levels, raising toxicity risk.

Moderate Interactions (Monitor Closely)

  • Warfarin: fenofibrate can enhance anticoagulant effect, requiring INR monitoring.
  • Oral hypoglycemics (e.g., sulfonylureas): may increase hypoglycemia risk.
  • Thyroid hormone replacement: fenofibrate may alter thyroid hormone levels.

Frequently Asked Questions

Lipanthyl contains fenofibrate and is prescribed to lower elevated triglyceride and cholesterol levels. It is indicated for hypertriglyceridaemia, mixed dyslipidaemia, and as an adjunct to statin therapy in primary hypercholesterolaemia.

Fenofibrate activates the nuclear receptor PPARα, which increases the expression of enzymes that oxidize fatty acids and clear triglyceride‑rich lipoproteins. This biochemical shift reduces plasma triglycerides and modestly improves HDL‑ and LDL‑cholesterol levels.

The specific dose of Lipanthyl is determined by the prescribing clinician based on the patient’s lipid profile, renal function, and concomitant medications. Dosage regimens are individualized and should follow the prescriber’s instructions.

Fenofibrate is classified as pregnancy category X, meaning it is contraindicated during pregnancy because of potential fetal harm. It is also not recommended while breastfeeding, as it may be excreted in milk.

To request Lipanthyl, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

The primary alternative to fenofibrate is the statin class, which primarily lowers LDL‑cholesterol. Fenofibrate is more effective at reducing triglycerides and modestly raising HDL‑cholesterol. In some patients, a combination of a statin and fenofibrate provides complementary lipid‑lowering benefits, though the combination requires careful monitoring for muscle toxicity.

Lipanthyl tablets should be stored at room temperature, below 25 °C, in the original container to protect them from moisture and light. Keep the product out of reach of children and do not use if the packaging is damaged.

Lipanthyl is taken orally, usually once daily with a meal to improve absorption. The tablet should be swallowed whole with a full glass of water and not crushed or chewed unless otherwise directed by a healthcare professional.

The most serious adverse events include rhabdomyolysis (severe muscle breakdown), significant liver injury, and acute pancreatitis. Patients should promptly report unexplained muscle pain, dark urine, jaundice, or severe abdominal pain to their clinician.

Lipanthyl should not be used by individuals who are pregnant, have severe liver disease, active gallbladder disease, or a known hypersensitivity to fenofibrate or any component of the formulation. Caution is also advised in patients with marked renal impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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