Product image of Lipanthyl (Fenofibrate (Nanonised)) supplied by GNH India

Lipanthyl

Active Ingredient:
Fenofibrate (Nanonised)
Origin:
EU

Lipanthyl (Fenofibrate (Nanonised))

Fenofibrate, the active ingredient in Lipanthyl, is a fibrate presented as an oral tablet for oral use. It is prescribed to manage elevated lipid levels, particularly high triglycerides and cholesterol, in adults with dyslipidaemia.
GNH India supplies Lipanthyl as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Viatris Medical

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Indications & Clinical Uses

Lipanthyl (fenofibrate) acts on lipid metabolism disorders and is used for the following clinical conditions:

  • Hypercholesterolemia: lowers total and LDL cholesterol levels.
  • Hypertriglyceridemia: reduces serum triglyceride concentrations.
  • Mixed dyslipidemia: improves the overall lipid profile by decreasing triglycerides and LDL while modestly raising HDL cholesterol.

How It Works

  • Fenofibrate activates peroxisome proliferator‑activated receptor‑alpha (PPAR‑α), a nuclear transcription factor that up‑regulates genes involved in fatty‑acid β‑oxidation. This enhances catabolism of triglyceride‑rich lipoproteins, decreases hepatic synthesis of very‑low‑density lipoprotein (VLDL), and modestly increases high‑density lipoprotein (HDL) production, resulting in improved plasma lipid parameters.

Side Effects

Adverse reactions to fenofibrate may vary in frequency and severity.

Common Side Effects

  • Gastrointestinal discomfort: nausea, abdominal pain, or dyspepsia.
  • Elevated liver enzymes: mild transaminase increases.
  • Muscle pain: myalgia without severe weakness.
  • Headache: mild to moderate intensity.
  • Skin reactions: rash or pruritus.

Serious or Rare Side Effects

  • Rhabdomyolysis: severe muscle breakdown with dark urine.
  • Hepatotoxicity: significant elevation of liver enzymes or jaundice.
  • Renal impairment: worsening kidney function.
  • Severe hypersensitivity: angioedema or anaphylactoid reactions.
  • Gallstones: increased risk of biliary sludge formation.

Precautions & Warnings

Before initiating therapy, consider the following safety measures:

  • Liver function: assess baseline hepatic enzymes and monitor periodically.
  • Renal function: evaluate creatinine clearance, especially in patients with existing kidney disease.
  • Muscle health: avoid concomitant use with statins without monitoring for myopathy.
  • Pregnancy and lactation: use only if the potential benefit outweighs risk, as safety data are limited.
  • Drug interactions: review all concomitant medications for possible interactions.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, and protect from moisture.

Avoid Interactions

Fenofibrate may interact with several drug classes, requiring vigilance.

Major Interactions (Avoid)

  • Statins (high‑dose): increased risk of rhabdomyolysis.
  • Anticoagulants (warfarin): potentiation of anticoagulant effect.
  • Bile‑acid sequestrants: reduced fenofibrate absorption.

Moderate Interactions (Monitor Closely)

  • Immunosuppressants (cyclosporine, tacrolimus): possible increase in serum levels.
  • Oral hypoglycemics: enhanced glucose‑lowering effect.
  • Thyroid hormones: potential alteration of thyroid function tests.

Frequently Asked Questions

Lipanthyl contains fenofibrate, a fibrate class medication used to treat dyslipidaemia. It helps lower elevated triglycerides, reduces LDL‑cholesterol, and can modestly raise HDL‑cholesterol in adults with hypercholesterolemia, hypertriglyceridemia, or mixed lipid disorders.

Fenofibrate activates the nuclear receptor PPAR‑α, which increases the expression of genes involved in fatty‑acid oxidation. This accelerates the breakdown of triglyceride‑rich particles, decreases VLDL production, and modestly raises HDL levels, thereby improving the overall lipid profile.

The dosage of Lipanthyl is individualized by a qualified prescriber based on the patient’s clinical condition, laboratory results, and response to therapy. Healthcare professionals determine the appropriate strength and dosing schedule for each patient.

Safety data for fenofibrate in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision must be made by the treating physician.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with statins, fenofibrate is more effective at reducing triglycerides and modestly raising HDL, but it has a lesser impact on LDL‑cholesterol. It is often used when triglyceride levels are the primary concern or in combination with a statin under careful monitoring.

Lipanthyl should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original container, protect them from moisture and direct sunlight, and ensure they are out of reach of children.

Lipanthyl is taken orally, usually with a meal to enhance absorption. The tablet should be swallowed whole with water and not crushed or chewed unless otherwise directed by a healthcare professional.

Serious adverse events, though rare, include rhabdomyolysis (severe muscle breakdown), significant liver enzyme elevations indicating hepatotoxicity, and acute renal failure. Patients should report unexplained muscle pain, dark urine, jaundice, or sudden changes in kidney function promptly.

Lipanthyl is contraindicated in patients with severe liver disease, end‑stage renal failure, known hypersensitivity to fenofibrate or any component of the formulation, and in those taking contraindicated medications such as certain high‑dose statins without appropriate monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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