Product image of Lipanthyl Micronised (Fenofibrate Micronised) supplied by GNH India

Lipanthyl Micronised

Active Ingredient:
Fenofibrate Micronised
Origin:
EU

Lipanthyl Micronised (Fenofibrate Micronised)

Fenofibrate, the active ingredient in Lipanthyl Micronised, is a fibrate presented as a micronised tablet for oral use. It is indicated for the management of hypertriglyceridaemia, mixed dyslipidaemia and as adjunct therapy in primary hypercholesterolaemia in adult patients.

GNH India supplies Lipanthyl Micronised as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, manufactured under EU GMP standards and ensuring quality and regulatory conformity across EU and global markets.

Manufacturer / TM Owner

Viatris Healthcare Nv/Sa

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Indications & Clinical Uses

Lipanthyl Micronised (fenofibrate) is used to treat disorders of lipid metabolism.

  • Hypertriglyceridaemia: lowers elevated serum triglyceride concentrations, helping to reduce the risk of pancreatitis.
  • Mixed dyslipidaemia: decreases triglycerides and low‑density lipoprotein (LDL) cholesterol while modestly increasing high‑density lipoprotein (HDL) cholesterol, supporting a more favorable lipid profile.
  • Primary hypercholesterolaemia (as adjunct therapy): used alongside statins to further improve lipid parameters, particularly triglycerides and HDL‑cholesterol.

How It Works

  • Fenofibrate acts as an agonist of the peroxisome proliferator‑activated receptor‑alpha (PPARα). Activation of PPARα up‑regulates genes involved in fatty‑acid β‑oxidation, reduces hepatic triglyceride synthesis, and increases the expression of apolipoproteins that raise HDL‑cholesterol, resulting in lowered plasma triglycerides and modest reductions in LDL‑cholesterol. It also enhances lipoprotein lipase activity, facilitating clearance of triglyceride‑rich lipoproteins, and decreases very‑low‑density lipoprotein (VLDL) production.

Side Effects

Fenofibrate may be associated with a range of adverse reactions, most of which are dose‑related and reversible upon discontinuation.

Common Side Effects

  • Gastrointestinal discomfort: nausea, abdominal pain or dyspepsia.
  • Elevated liver enzymes: transient increase in ALT/AST.
  • Muscle pain: mild myalgia without weakness.
  • Headache: occasional tension‑type headache.
  • Skin reactions: rash or pruritus.

Serious or Rare Side Effects

  • Rhabdomyolysis: muscle breakdown with markedly elevated creatine kinase.
  • Severe liver injury: hepatitis or hepatic failure.
  • Acute renal failure: sudden decrease in kidney function.

Precautions & Warnings

Before prescribing Lipanthyl Micronised, clinicians should consider several precautionary measures to minimise risk.

  • Liver function monitoring: assess baseline ALT/AST and repeat periodically.
  • Renal function assessment: evaluate serum creatinine and eGFR before initiation.
  • Muscle toxicity vigilance: monitor for unexplained muscle pain or weakness, especially with statins.
  • Pregnancy and lactation: avoid use unless potential benefit justifies potential risk.
  • Drug interactions: review concomitant medications that may increase risk of myopathy or affect fenofibrate levels.
  • Store at ambient temperature: keep below 25°C in the original packaging, protect from moisture.

Avoid Interactions

Fenofibrate can interact with several medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Statins (especially high‑dose simvastatin): increased risk of rhabdomyolysis.
  • Cyclosporine: elevated fenofibrate plasma concentrations.
  • Anticoagulants (warfarin): potentiation of anticoagulant effect.

Moderate Interactions (Monitor Closely)

  • Bile acid sequestrants (cholestyramine): reduced absorption of fenofibrate.
  • Gemfibrozil: additive risk of muscle toxicity.
  • Oral contraceptives: possible increase in triglyceride levels.

Frequently Asked Questions

Lipanthyl Micronised contains fenofibrate, a fibrate class lipid‑lowering agent. It is prescribed to lower elevated triglyceride levels in hypertriglyceridaemia, to improve the overall lipid profile in mixed dyslipidaemia, and as an adjunct to statin therapy in primary hypercholesterolaemia when additional triglyceride reduction or HDL‑cholesterol increase is needed.

Fenofibrate activates the nuclear receptor peroxisome proliferator‑activated receptor‑alpha (PPARα). This activation up‑regulates genes that enhance fatty‑acid β‑oxidation, suppress hepatic triglyceride synthesis, increase lipoprotein lipase activity, and raise HDL‑cholesterol production, collectively lowering plasma triglycerides and modestly reducing LDL‑cholesterol.

The appropriate dose of Lipanthyl Micronised is determined by the prescribing clinician based on the patient’s lipid profile, renal and hepatic function, and concomitant therapies. Dosage adjustments may be required for special populations, and the medication should be taken exactly as directed on the prescription label.

Safety data for fenofibrate during pregnancy and lactation are limited, and the drug is generally not recommended unless the potential benefit outweighs the potential risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternative lipid‑lowering strategies with their healthcare provider.

To request Lipanthyl Micronised, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details—including any required cold‑chain handling—and assistance with import documentation.

Compared with statins, fenofibrate primarily lowers triglycerides and raises HDL‑cholesterol, while statins are more potent at reducing LDL‑cholesterol. Unlike niacin, fenofibrate has a lower incidence of flushing. It is often combined with statins for complementary effects, but clinicians must monitor for increased risk of muscle toxicity when used together.

Lipanthyl Micronised tablets should be stored at ambient temperature, preferably below 25 °C, in their original blister pack to protect from moisture and light. Do not refrigerate or freeze the product, and keep it out of reach of children.

The medication is taken orally, usually once daily with a meal to enhance absorption. Patients should swallow the tablet whole with water and follow any specific instructions provided by their prescriber regarding timing relative to other drugs or meals.

The most serious adverse events include rhabdomyolysis, severe liver injury, and acute renal failure. These risks are heightened when fenofibrate is combined with high‑dose statins, cyclosporine, or other agents that affect muscle or liver metabolism. Prompt medical evaluation is required if patients experience unexplained muscle pain, dark urine, jaundice, or sudden changes in kidney function.

Lipanthyl Micronised is contraindicated in patients with known hypersensitivity to fenofibrate or any component of the formulation, in those with severe hepatic impairment, and in individuals with end‑stage renal disease requiring dialysis. Caution is also advised for patients with gallbladder disease or a history of pancreatitis.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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