Product image of Lipanthyl Nt (Fenofibrate (Nanonised)) supplied by GNH India

Lipanthyl Nt

Active Ingredient:
Fenofibrate (Nanonised)
Origin:
EU

Lipanthyl Nt (Fenofibrate (Nanonised))

Fenofibrate, the active ingredient in Lipanthyl Nt, is a fibrate presented as a nanonised oral tablet for oral use. It lowers elevated triglyceride levels and modifies lipid profiles in adults with dyslipidaemia. It is prescribed when lifestyle changes alone are insufficient to achieve target lipid levels.

GNH India supplies Lipanthyl Nt as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation to facilitate import and distribution across multiple regions.

Manufacturer / TM Owner

Viatris Healthcare Limited

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Indications & Clinical Uses

Fenofibrate acts on triglyceride‑rich lipoproteins to improve lipid abnormalities in several dyslipidaemia disorders.

  • Hypertriglyceridaemia: reduces serum triglyceride concentrations and lowers risk of pancreatitis.
  • Mixed dyslipidaemia: decreases triglycerides while modestly raising HDL‑cholesterol.
  • Primary hypercholesterolaemia (adjunct therapy): complements statin treatment to further improve lipid profile.

How It Works

  • Fenofibrate activates peroxisome proliferator‑activated receptor‑alpha (PPARα), a nuclear transcription factor that regulates genes involved in fatty‑acid oxidation. Activation enhances β‑oxidation of fatty acids in liver and muscle, reduces hepatic synthesis of triglycerides, and increases clearance of triglyceride‑rich lipoproteins such as VLDL. The net effect is lowered plasma triglyceride levels and modest increases in HDL‑cholesterol. Additionally, fenofibrate modulates apolipoprotein expression, contributing to improved lipid transport.

Side Effects

Fenofibrate may be associated with a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Gastrointestinal discomfort: nausea, abdominal pain or dyspepsia.
  • Headache: mild to moderate intensity.
  • Myalgia: muscle aches without weakness.
  • Elevated liver enzymes: transient increase in ALT or AST.
  • Dizziness or vertigo.
  • Fatigue: general feeling of tiredness.

Serious or Rare Side Effects

  • Rhabdomyolysis: severe muscle breakdown with risk of renal failure.
  • Acute liver injury: marked elevation of hepatic enzymes or jaundice.
  • Pancreatitis: inflammation of the pancreas.
  • Severe hypersensitivity: rash, angioedema or anaphylaxis.
  • Myopathy with renal impairment: muscle weakness with kidney dysfunction.

Precautions & Warnings

Before initiating fenofibrate therapy, several safety considerations should be reviewed.

  • Liver function monitoring: assess baseline enzymes and repeat periodically.
  • Renal function assessment: evaluate creatinine clearance, especially in the elderly.
  • Gallstone risk: avoid in patients with active biliary disease.
  • Concomitant statin use: limit dose and monitor for myopathy.
  • Pregnancy and lactation: contraindicated unless benefits outweigh risks.
  • Store at room temperature: keep in original container, protect from moisture and heat.

Avoid Interactions

Fenofibrate can interact with other medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Gemfibrozil: combined use markedly increases risk of rhabdomyolysis.
  • Cyclosporine: may raise fenofibrate plasma levels, enhancing toxicity.
  • High‑dose statins (e.g., rosuvastatin >20 mg): increased incidence of myopathy.

Moderate Interactions (Monitor Closely)

  • Warfarin: fenofibrate may potentiate anticoagulant effect, requiring INR monitoring.
  • Oral hypoglycemics: may enhance glucose‑lowering effect, risk of hypoglycaemia.

Frequently Asked Questions

Lipanthyl Nt contains fenofibrate, a fibrate class medication indicated for the management of hypertriglyceridaemia, mixed dyslipidaemia, and as an adjunct to statin therapy in primary hypercholesterolaemia. It helps lower elevated triglyceride levels and improve overall lipid profiles in adult patients.

Fenofibrate activates the nuclear receptor PPARα, which regulates genes involved in fatty‑acid oxidation and lipoprotein metabolism. This activation increases the breakdown of fatty acids, reduces hepatic triglyceride production, and enhances clearance of triglyceride‑rich particles, resulting in lower plasma triglycerides and modest HDL‑cholesterol rises.

The appropriate dose of Lipanthyl Nt is determined by the prescribing healthcare professional based on the individual’s clinical condition, laboratory results, and response to therapy. Patients should follow the prescriber’s instructions and not adjust the dose without medical guidance.

Safety data for fenofibrate in pregnancy and lactation are limited, and the product is generally not recommended for use unless the potential benefit justifies the potential risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives with their physician.

To order Lipanthyl Nt, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

The primary alternative to fenofibrate is the statin class, which primarily lowers LDL‑cholesterol. Fenofibrate is more effective at reducing triglycerides and modestly raising HDL‑cholesterol, whereas statins have a stronger impact on LDL‑cholesterol. In some patients, a combination of a statin and a fibrate may be used, but careful monitoring for muscle toxicity is required.

Lipanthyl Nt should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and excessive heat. Keep the product out of reach of children and avoid exposure to direct sunlight.

Lipanthyl Nt is taken orally, usually with a meal to enhance absorption. The tablet should be swallowed whole with a full glass of water. Patients should not crush or chew the tablet unless specifically instructed by a healthcare professional.

The most serious adverse reactions include rhabdomyolysis (severe muscle breakdown), acute liver injury, and pancreatitis. Patients should promptly report unexplained muscle pain, weakness, dark urine, jaundice, or severe abdominal pain to their healthcare provider.

Lipanthyl Nt should be avoided in patients with severe hepatic impairment, active gallbladder disease, known hypersensitivity to fenofibrate or other fibrates, and in individuals for whom the risk outweighs the benefit, such as certain pregnant or nursing women. Contraindications are confirmed by the prescribing clinician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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