Product image of Lipanthyl Nt (Fenofibrate (Nanonised)) supplied by GNH India

Lipanthyl Nt

Active Ingredient:
Fenofibrate (Nanonised)
Origin:
EU

Lipanthyl Nt (Fenofibrate (Nanonised))

Fenofibrate, the active ingredient in Lipanthyl Nt, is a fibrate presented as a nanonised oral tablet for oral use. It lowers elevated triglyceride levels and improves lipid profiles in adults with dyslipidaemia. It is indicated for the management of hypertriglyceridaemia, mixed dyslipidaemia, and as adjunct therapy in primary hypercholesterolaemia, helping reduce cardiovascular risk in patients with abnormal lipid metabolism.

GNH India supplies Lipanthyl Nt as a licensed, GDP‑compliant international pharmaceutical supplier, providing reliable bulk and parcel shipments to hospitals, pharmacies and clinics worldwide, with adherence to quality standards and regulatory requirements across EU and other markets.

Manufacturer / TM Owner

Viatris Healthcare Limited

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Indications & Clinical Uses

Fenofibrate acts on lipid metabolism to treat various forms of dyslipidaemia.

  • Hypertriglyceridaemia: reduces serum triglyceride concentrations, lowering risk of pancreatitis.
  • Mixed dyslipidaemia: lowers triglycerides and LDL‑cholesterol while modestly raising HDL‑cholesterol.
  • Primary hypercholesterolaemia (adjunct): enhances the lipid‑lowering effect of statins by further decreasing LDL‑cholesterol.

How It Works

  • Fenofibrate activates peroxisome proliferator‑activated receptor‑α (PPARα), a nuclear transcription factor that up‑regulates genes involved in fatty‑acid β‑oxidation and lipoprotein metabolism. Activation increases the catabolism of triglyceride‑rich lipoproteins, enhances lipoprotein lipase activity, and reduces hepatic synthesis of very‑low‑density lipoprotein, resulting in lowered plasma triglycerides and modest improvements in LDL‑ and HDL‑cholesterol levels. These changes contribute to an overall improvement in the atherogenic lipid profile.

Side Effects

Fenofibrate may be associated with a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Gastrointestinal discomfort: mild nausea, abdominal pain or dyspepsia.
  • Headache: transient mild to moderate headache episodes.
  • Elevated liver enzymes: temporary increase in hepatic transaminases.
  • Muscle cramps: occasional mild muscle soreness.

Serious or Rare Side Effects

  • Myopathy or rhabdomyolysis: severe muscle pain with weakness and possible kidney injury.
  • Severe liver injury: jaundice, hepatitis or hepatic failure.
  • Acute renal failure: sudden decline in kidney function.
  • Allergic reactions: rash, pruritus or angio‑edema.

Precautions & Warnings

Before initiating fenofibrate therapy, clinicians should evaluate several clinical factors to ensure safe use.

  • Renal function: assess baseline creatinine clearance and monitor periodically.
  • Hepatic disease: avoid in active liver disease and monitor liver enzymes.
  • Pregnancy: use only if potential benefit justifies potential risk to the fetus.
  • Statin co‑therapy: limit high‑dose statin use to reduce myopathy risk.
  • Gout: monitor serum uric acid as fenofibrate may precipitate gout attacks.
  • Store at ambient temperature: keep below 25 °C, in original packaging, protected from moisture.

Avoid Interactions

Fenofibrate can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Gemfibrozil: combined use markedly increases risk of myopathy.
  • High‑dose statins (e.g., rosuvastatin >20 mg): heightened myopathy potential.
  • Cyclosporine: may raise fenofibrate plasma concentrations.

Moderate Interactions (Monitor Closely)

  • Warfarin: fenofibrate may enhance anticoagulant effect, requiring INR monitoring.
  • Antidiabetic agents: may affect glycemic control, adjust doses as needed.
  • Thiazide diuretics: can increase serum uric acid, risking gout flares.

Frequently Asked Questions

Lipanthyl Nt contains fenofibrate, a fibrate class medication indicated for the treatment of hypertriglyceridaemia, mixed dyslipidaemia, and as an adjunct to statin therapy in primary hypercholesterolaemia. It helps lower elevated triglyceride levels and improves overall lipid profiles in patients with abnormal blood lipids.

Fenofibrate activates the nuclear receptor peroxisome proliferator‑activated receptor‑α (PPARα). This activation up‑regulates genes that increase fatty‑acid oxidation, enhance lipoprotein lipase activity, and reduce hepatic production of very‑low‑density lipoprotein, leading to lower plasma triglycerides and modest improvements in LDL‑ and HDL‑cholesterol.

The specific dose of Lipanthyl Nt is determined by the prescribing clinician based on the patient’s individual clinical condition, laboratory values, and response to therapy. Dosage may be adjusted according to therapeutic goals and tolerability, and should follow the prescriber’s written instructions.

Safety data for fenofibrate during pregnancy and lactation are limited. The drug should only be used if the potential benefit to the mother outweighs any possible risk to the fetus. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss alternatives with their healthcare provider.

To order Lipanthyl Nt, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials. The sales team will then provide pricing, availability, shipping details and any necessary import documentation.

The primary alternative to fenofibrate is another fibrate, gemfibrozil, which also lowers triglycerides but has a higher risk of drug‑drug interactions, especially with statins. Compared with statins, fenofibrate is less potent at lowering LDL‑cholesterol but is more effective at reducing triglycerides, making it useful when triglyceride reduction is the primary goal.

Lipanthyl Nt should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original container, protect them from moisture and direct sunlight, and ensure the packaging remains tightly closed until use.

Lipanthyl Nt is administered orally, usually once daily with a meal to enhance absorption. Patients should swallow the tablet whole with water and follow any additional instructions provided by their prescriber regarding timing relative to food.

The most serious adverse events associated with fenofibrate include myopathy or rhabdomyolysis (especially when combined with certain statins), severe liver injury, and acute renal failure. Patients should promptly report unexplained muscle pain, weakness, dark urine, jaundice, or sudden changes in kidney function to their healthcare professional.

Lipanthyl Nt is contraindicated in patients with severe hepatic impairment, active gallbladder disease, or known hypersensitivity to fenofibrate or any excipients. Caution is also advised for individuals with moderate renal impairment, uncontrolled hypothyroidism, or a history of gallstones.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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