Product image of Lipanthyl Nt (Fenofibrate (Nanonised)) supplied by GNH India

Lipanthyl Nt

Active Ingredient:
Fenofibrate (Nanonised)
Origin:
EU

Lipanthyl Nt (Fenofibrate (Nanonised))

Fenofibrate, the active ingredient in Lipanthyl Nt, is a fibrate presented as a tablet for oral use. It treats hypertriglyceridemia and related lipid disorders in adults.

GNH India supplies Lipanthyl Nt as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Viatris Healthcare Limited

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Indications & Clinical Uses

Fenofibrate is used to modify lipid profiles in disorders characterized by elevated triglycerides and mixed dyslipidaemia.

  • Hypertriglyceridemia: reduces markedly elevated triglyceride concentrations.
  • Mixed dyslipidaemia: improves overall lipid profile by lowering triglycerides and modestly raising HDL‑cholesterol.
  • Primary hypercholesterolaemia (as adjunct therapy): enhances LDL‑cholesterol reduction when combined with statins.

How It Works

  • Fenofibrate acts as an agonist of peroxisome proliferator‑activated receptor alpha (PPARα). Activation of PPARα up‑regulates genes involved in fatty‑acid β‑oxidation, lipoprotein lipase activity, and apolipoprotein synthesis, leading to increased clearance of triglyceride‑rich lipoproteins and a modest reduction in LDL‑cholesterol while raising HDL‑cholesterol levels.

Side Effects

Fenofibrate may cause a range of adverse reactions, from mild to serious.

Common Side Effects

  • Gastrointestinal discomfort: nausea, abdominal pain, dyspepsia.
  • Headache.
  • Elevated liver enzymes.
  • Muscle pain or weakness.
  • Increased serum creatinine.
  • Skin rash.

Serious or Rare Side Effects

  • Rhabdomyolysis or severe myopathy.
  • Acute liver injury or hepatitis.
  • Pancreatitis.
  • Severe allergic reactions (e.g., Stevens‑Johnson syndrome).
  • Renal impairment.
  • Hemorrhagic complications when combined with anticoagulants.

Precautions & Warnings

Before initiating therapy, clinicians should assess relevant clinical factors and monitor patients during treatment.

  • Liver function: evaluate baseline hepatic enzymes and monitor periodically.
  • Renal function: assess creatinine clearance, especially in the elderly.
  • Gallstone disease: avoid in patients with active biliary disease.
  • Severe hypertriglyceridaemia (>1000 mg/dL): consider alternative or adjunctive therapy.
  • Concomitant statin use: monitor for signs of myopathy.
  • Store at room temperature: keep in the original pack, protect from moisture and direct sunlight.

Avoid Interactions

Fenofibrate can interact with several medicines, requiring avoidance or careful monitoring.

Major Interactions (Avoid)

  • Gemfibrozil: markedly increases risk of myopathy.
  • Cyclosporine: raises fenofibrate plasma concentrations.
  • Warfarin: may potentiate anticoagulant effect.
  • HIV protease inhibitors: increase fenofibrate exposure.
  • High‑dose statins: elevate risk of rhabdomyolysis.

Moderate Interactions (Monitor Closely)

  • Anticoagulants (e.g., dabigatran): monitor coagulation parameters.
  • Thyroid hormones: adjust levothyroxine dose as needed.
  • Oral contraceptives: observe for lipid changes.
  • Niacin: increased potential for hepatotoxicity.
  • Digoxin: possible increase in serum levels.

Frequently Asked Questions

Lipanthyl Nt contains fenofibrate, which is prescribed to lower high triglyceride levels, improve mixed dyslipidaemia, and serve as an adjunct therapy for primary hypercholesterolaemia when used together with statins. It helps restore a healthier lipid profile in adult patients with these disorders.

Fenofibrate activates the nuclear receptor PPARα, which regulates genes involved in fatty‑acid oxidation and lipoprotein metabolism. This activation increases the breakdown of triglyceride‑rich particles, reduces hepatic production of very‑low‑density lipoprotein, and modestly raises HDL‑cholesterol, resulting in an overall improvement of the lipid profile.

The appropriate dose of Lipanthyl Nt is determined by the prescribing healthcare professional based on the patient’s clinical condition, laboratory results, and concomitant therapies. Dosage adjustments are individualized, and patients should follow the prescriber’s instructions without self‑adjusting the regimen.

Fenofibrate is generally not recommended for use during pregnancy or while breastfeeding unless the potential benefit justifies the potential risk to the fetus or infant. Women of child‑bearing potential should discuss contraception and risk assessment with their healthcare provider before starting therapy.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity of Lipanthyl Nt. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with statins, fenofibrate primarily targets triglycerides and modestly raises HDL‑cholesterol, whereas statins mainly lower LDL‑cholesterol. In patients with mixed dyslipidaemia, fenofibrate can be used alone or in combination with statins to achieve broader lipid control, but the combination requires monitoring for muscle‑related adverse effects.

Lipanthyl Nt should be stored at room temperature, below 25 °C, in its original packaging. Keep the tablets away from moisture, heat, and direct sunlight to maintain stability and potency throughout the shelf life.

Lipanthyl Nt is taken orally, usually with a meal to enhance absorption. The tablet should be swallowed whole with water and not crushed or chewed, unless otherwise directed by a healthcare professional.

The most serious risks include rhabdomyolysis or severe myopathy, especially when combined with statins or gemfibrozil, as well as acute liver injury, pancreatitis, and rare severe allergic reactions. Patients should promptly report unexplained muscle pain, dark urine, jaundice, or signs of an allergic response.

Lipanthyl Nt is contraindicated in patients with severe liver disease, active gallbladder disease, known hypersensitivity to fenofibrate or other fibrates, and in those with uncontrolled severe hypertriglyceridaemia (>1000 mg/dL). Caution is also advised for individuals with renal impairment or those taking interacting medications.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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