Product image of Lipanthyl S (Fenofibrate) supplied by GNH India

Lipanthyl S

Active Ingredient:
Fenofibrate
Origin:
EU

Lipanthyl S (Fenofibrate)

Fenofibrate, the active ingredient in Lipanthyl S, is a fibrate presented as an oral tablet for oral administration. It is indicated for the management of hypertriglyceridemia, mixed dyslipidemia, and as an adjunct to statin therapy in primary hypercholesterolemia, helping to lower elevated triglyceride levels and improve overall lipid profiles in adult patients.

GNH India supplies Lipanthyl S as a licensed, GDP‑compliant international pharmaceutical supplier, providing the product to hospitals, pharmacies, and clinics across global markets while adhering to stringent quality standards and regulatory requirements.

Manufacturer / TM Owner

Viatris Healthcare Limited

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Indications & Clinical Uses

Fenofibrate is used to treat disorders of lipid metabolism, particularly conditions characterized by elevated triglyceride levels.

  • Hypertriglyceridemia: lowers serum triglyceride concentrations and reduces risk of pancreatitis.
  • Mixed dyslipidemia: decreases triglycerides, modestly raises HDL‑cholesterol and contributes to overall lipid profile improvement.
  • Primary hypercholesterolemia (adjunct): used with statins to further reduce LDL‑cholesterol and triglycerides in patients requiring additional lipid lowering.

How It Works

  • Fenofibrate activates peroxisome proliferator‑activated receptor‑alpha (PPAR‑α), a nuclear transcription factor that regulates genes involved in lipid metabolism. Activation enhances β‑oxidation of fatty acids, increases lipoprotein lipase activity, and reduces hepatic synthesis of very‑low‑density lipoprotein (VLDL). These actions collectively promote clearance of triglyceride‑rich particles and modestly raise high‑density lipoprotein (HDL) levels.

Side Effects

Fenofibrate may be associated with a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Gastrointestinal discomfort: nausea, abdominal pain or dyspepsia.
  • Headache: mild to moderate intensity.
  • Elevated liver enzymes: transient increases in ALT or AST.
  • Muscle pain: mild myalgia without weakness.

Serious or Rare Side Effects

  • Rhabdomyolysis: severe muscle breakdown, especially when combined with statins.
  • Acute liver injury: jaundice or hepatitis-like presentation.
  • Pancreatitis: inflammation of the pancreas presenting with abdominal pain.
  • Severe allergic reactions: rash, angioedema or anaphylaxis.

Precautions & Warnings

When prescribing Fenofibrate, clinicians should observe several precautionary measures to ensure safe use.

  • Liver function monitoring: obtain baseline enzymes and repeat periodically.
  • Renal function assessment: evaluate creatinine clearance, especially in severe impairment.
  • Gallbladder disease: avoid use in patients with active biliary obstruction or gallstones.
  • Concomitant statin therapy: use the lowest effective statin dose and monitor for myopathy.
  • Pregnancy and lactation: prescribe only if potential benefit justifies potential risk to the fetus or infant.
  • Store at room temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Fenofibrate can interact with several medicines; understanding the interaction level guides clinical management.

Major Interactions (Avoid)

  • Gemfibrozil: combined use markedly increases risk of myopathy and rhabdomyolysis.
  • High‑dose simvastatin: concurrent therapy raises the likelihood of severe muscle toxicity.
  • Warfarin: fenofibrate may potentiate anticoagulant effect, requiring INR monitoring.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors: monitor renal function and blood pressure for additive effects.
  • Oral contraceptives: may experience altered lipid levels, requiring periodic assessment.

Frequently Asked Questions

Lipanthyl S, containing fenofibrate, is prescribed for adults with hypertriglyceridemia, mixed dyslipidemia, and as an adjunct to statin therapy in primary hypercholesterolemia. The drug helps lower elevated triglyceride levels and improves the overall lipid profile, reducing the risk of complications such as pancreatitis.

Fenofibrate activates the nuclear receptor PPAR‑α, which regulates genes involved in fatty‑acid oxidation and lipoprotein metabolism. This activation increases the breakdown of triglyceride‑rich particles, enhances lipoprotein lipase activity, and reduces hepatic production of VLDL, leading to lower serum triglycerides and modestly higher HDL‑cholesterol.

The appropriate dose of Lipanthyl S is determined by the prescribing clinician based on the individual patient's lipid profile, underlying health conditions, concomitant medications, and response to therapy. Dosage adjustments may be needed for renal or hepatic impairment, and the prescriber will follow local labeling and clinical guidelines.

Safety data for fenofibrate in pregnancy and lactation are limited. The drug should be used only if the potential benefit to the mother outweighs any possible risk to the fetus or infant. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss alternatives with their healthcare provider.

To order Lipanthyl S, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Statins primarily reduce LDL‑cholesterol by inhibiting HMG‑CoA reductase, whereas fenofibrate (Lipanthyl S) mainly lowers triglycerides and modestly raises HDL‑cholesterol through PPAR‑α activation. Fenofibrate is often used as an adjunct to statins when triglyceride levels remain high despite statin therapy, offering a complementary mechanism of action.

Lipanthyl S should be stored at room temperature, below 25 °C, in its original packaging. Keep the tablets away from moisture, direct sunlight, and excessive heat. Do not store in the bathroom or near a kitchen sink where humidity is high.

Lipanthyl S is taken orally, usually as a tablet, with meals to improve absorption and reduce gastrointestinal discomfort. The exact timing and frequency are set by the prescriber, who may adjust the regimen based on the patient’s lipid levels and tolerance.

Serious adverse events linked to Lipanthyl S include rhabdomyolysis (especially when combined with statins), acute liver injury, pancreatitis, and severe allergic reactions such as anaphylaxis. Patients should be monitored for muscle pain, unexplained weakness, jaundice, or signs of an allergic response and seek medical attention promptly if they occur.

Lipanthyl S is contraindicated in patients with severe liver disease, active gallbladder disease or biliary obstruction, known hypersensitivity to fenofibrate or any excipients, and in individuals for whom the risks of therapy outweigh the benefits, such as certain pregnant or nursing women without a clear clinical indication.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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